2016 American Transplant Congress
Direct IL-33 Stimulation of T Regulatory Cells via Suppression of Tumorigenicity 2 (ST2) Is Required for Effective Control of Alloimmune Responses.
Background: IL-33 is a pleotropic cytokine that can protect against cardiac transplant rejection by expanding regulatory T cells (Treg), particularly a Treg subset expressing the…2016 American Transplant Congress
High PD-L1/CD86 MFI Ratio and IL-10 Secretion Characterize Maturation-Resistant Human Regulatory Dendritic Cells (DCregs) Generated for Clinical Testing in Transplantation.
Regulatory dendritic cells (DCregs) have shown considerable potential for safe and effective prolongation of allograft survival in pre-clinical models. In humans, DCregs with purity >84%…2016 American Transplant Congress
Belatacept Does Not Inhibit Plasmablast Formation Supported by Follicular T Helper Cells, but Favors the Development of Transitional Regulatory B Cells in Kidney Transplant Patients.
Since the costimulatory inhibitor belatacept effectively blocks T-B cell interaction in animal transplant models, we studied the functional follicular T helper cells (TFH)-B cell interaction…2016 American Transplant Congress
Rapamycin Nanotherapy Delays Heart Transplant Rejection.
Background:In patients, allograft survival requires a cocktail of immunosuppressive drugs, while experimentally antibodies targeting the innate immune system have been shown to induce long-term tolerance,…2016 American Transplant Congress
Prior Infection or Colonization with Carbapenem-Resistant Enterobacteriaceae Is Not an Absolute Contraindication for Solid Organ Transplantation.
BackgroundCarbapenem-resistant Enterobacteriaceae (CRE) infection is associated with poor outcomes after solid organ transplantation (SOT). The significance of CRE colonization or infection prior to SOT is…2016 American Transplant Congress
Probability, Risk Factors, and Long-Term Outcomes of Biliary Complications After Hepatic Artery Thrombosis in Adult Liver Transplant Recipients: 20 Years Experience from a Single Center.
General Surgery, Cleveland Clinic, Cleveland, OH.
Hepatic artery thrombosis (HAT) after liver transplantation (LT) is a devastating complication associated with ischemic biliary cholangiopathy (IBC) that can occur even after successful revascularization.…2016 American Transplant Congress
DNA Methylation Patterns and Association with Graft Injury Severity Post Liver Transplantation.
Background: Epigenetics modifications in the graft may influence injury severity and function post liver transplantation (LT). This study aimed to interrogate the effect of different…2016 American Transplant Congress
Long-Term Outcomes of ATG versus IL-2 Receptor Antagonist in Low Risk Kidney Transplant Recipients: Donor Factors.
Controversy exists regarding the optimal choice of induction therapy in low-risk kidney transplant (KT) recipients. Current guidelines specify induction choices in KT based on recipient…2016 American Transplant Congress
Investigating Geographic Variation in the Number of Deceased Donor Transplants Performed in the U.S.
Background: In 2014 the number of deceased donor transplants (DDT) increased greatly compared to the period from 2005 to 2013 when there were minimal changes…2016 American Transplant Congress
Efficacy and Safety of Direct Antiviral Agents (DAA)-Based Therapies for Hepatitis C Virus (HCV) Infection in Kidney Transplant (KT) Recipients.
Background: The use of interferon-based regimens for HCV infection in KT recipients is limited due to the increased risk of acute graft rejection (AR), poor…
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