Am J Transplant, Volume 16, Suppl 3 Archives - Page 11 of 180 - ATC Abstracts

2016 American Transplant Congress
Deceased Organ Donor Management: Does Hospital Volume Matter?
M. Patel,¹ J. Mohebali,¹ M. Sally,² T. Groat,² P. Vagefi,¹ D. Chang,¹ D. Malinoski.²
¹Massachusetts General Hospital, Boston; ²Portland Veterans Affairs Medical Center and Oregon Health & Science University, Portland.
Purpose: Despite the association between hospital volume and outcomes for various diseases, there have been no studies to assess the impact of hospital organ donor…
2016 American Transplant Congress
Viral Gastroenteritis in Adult and Pediatric Solid Organ Transplant (SOT) Patients.
C. Hernández Garcia,¹ B. Lee,¹ X. Pang,² H. Yuan Zhou,¹ J. Preikisatis.¹
¹Medicine, University of Alberta, Edmonton, AB, Canada; ²Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada.
BACKGROUND. Diarrhea in SOT recipients is common and often attributed to immunosuppressive drug side effects. However, enteric viruses are important causes of acute gastroenteritis and…
2016 American Transplant Congress
Human MicroRNA Responses Are Predictive of CMV Reactivation Following Solid Organ Transplant.
S. Han,¹ D. Kumar,¹ V. Ferreira,¹ S. Husain,¹ N. Mueller,² A. Humar,¹ M. Mian,¹ P. Ashton.¹
¹Multi Organ Transplant Program, University Health Network, Toronto, Canada; ²Swiss Transplant Cohort Study, University Hospital Zurich, Zurich, Switzerland.
Background: Human microRNA (miRNA) can suppress gene expression through binding to the 3' untranslated region (UTR) of the target mRNA. In silico analysis shows that,…
2016 American Transplant Congress
Direct IL-33 Stimulation of T Regulatory Cells via Suppression of Tumorigenicity 2 (ST2) Is Required for Effective Control of Alloimmune Responses.
X. Zhang,^1,3 B. Matta,¹ D. Reichenbach,² B. Blazar,² H. Turnquist.¹
¹Dept of Surgery, Starzl Transplantation Inst, Pittsburgh, PA; ²Dept of Pediatrics, Univ of Minnesota, Minneapolis, MN; ³Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
Background: IL-33 is a pleotropic cytokine that can protect against cardiac transplant rejection by expanding regulatory T cells (Treg), particularly a Treg subset expressing the…
2016 American Transplant Congress
High PD-L1/CD86 MFI Ratio and IL-10 Secretion Characterize Maturation-Resistant Human Regulatory Dendritic Cells (DCregs) Generated for Clinical Testing in Transplantation.
A. Zahorchak,¹ L. Butterfield,^2,3 C. Macedo,¹ D. Hamm,⁴ D. Metes,^1,3 A. Thomson.^1,3
¹Surgery, Thomas E. Starzl Transplantation Institute, Pittsburgh; ²Medicine, University of Pittsburgh, Pittsburgh; ³Immunology, University of Pittsburgh, Pittsgurgh; ⁴Adaptive Biotech, Seattle.
Regulatory dendritic cells (DCregs) have shown considerable potential for safe and effective prolongation of allograft survival in pre-clinical models. In humans, DCregs with purity >84%…
2016 American Transplant Congress
Belatacept Does Not Inhibit Plasmablast Formation Supported by Follicular T Helper Cells, but Favors the Development of Transitional Regulatory B Cells in Kidney Transplant Patients.
G. de Graav, D. Hesselink, M. Dieterich, R. Kraaijeveld, W. Weimar, C. Baan.
Internal Medicine, Section Transplantation and Nephrology, Erasmus University Medical Center, Rotterdam, South Holland, Netherlands.
Since the costimulatory inhibitor belatacept effectively blocks T-B cell interaction in animal transplant models, we studied the functional follicular T helper cells (TFH)-B cell interaction…
2016 American Transplant Congress
Rapamycin Nanotherapy Delays Heart Transplant Rejection.
M. Braza,¹ M. Lameijer,¹ C. Perez-Medina,¹ T. Reiner,³ M. Nahrendorf,⁴ Z. Fayad,¹ R. Duivenvoorden,¹ J. Ochando,² W. Mulder.¹
¹Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York; ²Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York; ³Radiology, Memorial Sloan-Kettering Cancer Center, New York; ⁴Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston.
Background:In patients, allograft survival requires a cocktail of immunosuppressive drugs, while experimentally antibodies targeting the innate immune system have been shown to induce long-term tolerance,…
2016 American Transplant Congress
Prior Infection or Colonization with Carbapenem-Resistant Enterobacteriaceae Is Not an Absolute Contraindication for Solid Organ Transplantation.
S. Huprikar,¹ L. Casner,¹ S. Pouch,² M. Pinheiro Freire,³ R. Madan,⁴ E. Kwak,⁵ M. Satlin,⁶ P. Hartman,⁷ L. Pisney,⁸ P. Henrique Mourão,⁹ R. La Hoz,¹⁰ G. Patel.¹
¹Mount Sinai, New York; ²Ohio State, Columbus; ³Sao Paulo University, Sao Paulo, Brazil; ⁴Albert Einstein, Bronx; ⁵University of Pittsburgh, Pittsburgh; ⁶Cornell, New York; ⁷Henry Ford Health System, Detroit; ⁸University of Colorado, Denver; ⁹Universidade Federal de Minas Gerais, Belo Horizonte, Brazil; ¹⁰UT Southwestern, Dallas.
BackgroundCarbapenem-resistant Enterobacteriaceae (CRE) infection is associated with poor outcomes after solid organ transplantation (SOT). The significance of CRE colonization or infection prior to SOT is…
2016 American Transplant Congress
Probability, Risk Factors, and Long-Term Outcomes of Biliary Complications After Hepatic Artery Thrombosis in Adult Liver Transplant Recipients: 20 Years Experience from a Single Center.
M. Fujiki, K. Hashimoto, T. Diago, C. Quintini, F. Aucejo, D. Kelly, B. Eghtesad, J. Fung, C. Miller.
General Surgery, Cleveland Clinic, Cleveland, OH.
Hepatic artery thrombosis (HAT) after liver transplantation (LT) is a devastating complication associated with ischemic biliary cholangiopathy (IBC) that can occur even after successful revascularization.…
2016 American Transplant Congress
DNA Methylation Patterns and Association with Graft Injury Severity Post Liver Transplantation.
R. Gehrau, S. Bontha, V. Mas, D. Maluf.
UVA, Charlottesville.
Background: Epigenetics modifications in the graft may influence injury severity and function post liver transplantation (LT). This study aimed to interrogate the effect of different…