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Vitamin D Deficiency in Liver Transplant Recipients

V. Subramanian1, T. Lippert2, J. Buggs1, N. Kemmer1, K. Dhanireddy1

1Transplant Institute, Tampa General Hospital, Tampa, FL, 2University of South Florida, Tampa, FL

Meeting: 2022 American Transplant Congress

Abstract number: 1428

Keywords: Liver cirrhosis, Liver transplantation, Osteoporosis, Post-operative complications

Topic: Clinical Science » Liver » 53 - Liver: Cirrhosis - Portal Hypertension and Other Complications

Session Information

Session Name: Liver: Cirrhosis - Portal Hypertension and Other Complications

Session Type: Poster Abstract

Date: Monday, June 6, 2022

Session Time: 7:00pm-8:00pm

 Presentation Time: 7:00pm-8:00pm

Location: Hynes Halls C & D

*Purpose: Patients with chronic liver disease are at risk of nutritional deficiency. The goal of this study was to determine the prevalence of vitamin D deficiency in Liver Transplant (LTx) recipients and study the effects of a vitamin D supplementation protocol after LTx.

*Methods: Retrospective analysis of adult LTx performed at our institution between 7/1/2019 to 3/1/2021. Pre-LTx and post-LTx data was collected including details on vitamin D supplementation, and both pre and post LTx vitamin D related complications. A vitamin D supplementation protocol based on pre-transplant Vitamin D levels with patients receiving either high dose (50,000 U weekly) or low dose (1000U daily) was implemented. Statistical analysis was performed.

*Results: 255 LTx recipients were included in the study. Pre LTx vitamin D deficiency was noted in 196 (79.7%) of LTx recipients. 18.1% patients had osteoporosis pre-LTx. With both either high dose or low dose vitamin D, there was a significant increase in Vitamin D levels (mean change 21.9 ng/mL) compared to pre-LTx. This also resulted in decreased rates of osteoporosis in patients who received vitamin D supplementation. No differences were noted in other post LTx outcomes including survival, rejection in patients receiving vitamin D supplementation.

*Conclusions: Vitamin D deficiency is highly prevalent in LTx recipients. Routine screening pre-LTx and post transplant vitamin D supplementation should be part of care of LTx recipients.

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To cite this abstract in AMA style:

Subramanian V, Lippert T, Buggs J, Kemmer N, Dhanireddy K. Vitamin D Deficiency in Liver Transplant Recipients [abstract]. Am J Transplant. 2022; 22 (suppl 3). https://atcmeetingabstracts.com/abstract/vitamin-d-deficiency-in-liver-transplant-recipients/. Accessed May 30, 2025.

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