Verification of OPTN Hepatocellular Carcinoma Recurrence Data
1Perelman School of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA
2Division of Gastroenterology, Hospital of the University of Pennsylvania, Philadelphia, PA
3Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA.
Meeting: 2015 American Transplant Congress
Abstract number: D183
Keywords: Liver transplantation, Post-transplant malignancy
Session Information
Session Name: Poster Session D: Liver Transplantation for Hepatocellular Carcinoma
Session Type: Poster Session
Date: Tuesday, May 5, 2015
Session Time: 5:30pm-6:30pm
Presentation Time: 5:30pm-6:30pm
Location: Exhibit Hall E
PURPOSE: OPTN data on HCC recurrence is increasingly utilized for a variety of studies; however, the accuracy of this data has not been examined. We hypothesized that OPTN HCC recurrence is underreported when compared to discrete transplant center data.
METHODS: Patients undergoing liver transplantation with HCC exception points from February 27, 2002 to December 31, 2011 at a single institution were studied for HCC recurrence (gold standard) and compared to corresponding patients within the OPTN database with reported HCC recurrence.
RESULTS: 293 patients underwent liver transplantation for HCC, of which 34 were identified with recurrence. OPTN data failed to identify 8 of these recurrences and incorrectly classified one patient with a recurrence. OPTN data had a sensitivity of 76.5% and specificity of 99.6% for HCC recurrence.
| Center Positive Recurrence | Center Negative Recurrence | Total | |
| UNOS Positive Recurrence | 26 | 1 | 27 |
| UNOS Negative Recurrence | 8 | 258 | 266 |
| Total | 34 | 259 | 293 |
CONCLUSIONS: Although documentation of recurrent HCC in OPTN data is indicative of a true HCC recurrence, OPTN data alone fail to identify a substantial number of true cases of HCC recurrence. Validation of these findings among other transplant centers may have implications for transplant policy and studies of HCC recurrence.
To cite this abstract in AMA style:
George J, Eddinger K, Goldberg D, Levine M, Abt P. Verification of OPTN Hepatocellular Carcinoma Recurrence Data [abstract]. Am J Transplant. 2015; 15 (suppl 3). https://atcmeetingabstracts.com/abstract/verification-of-optn-hepatocellular-carcinoma-recurrence-data/. Accessed May 9, 2025.« Back to 2015 American Transplant Congress