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United Kingdom National Outcomes of Transplants from Paediatric Donors: 10 Years Experience

M. A. Khurram, N. Karydis, C. Callaghan, I. Loukopoulos, T. Kasimatis, P. Chandak, F. Calder, N. Mamode, N. Kessaris

Transplantation, Guy's and St Thomas NHS trust, London, United Kingdom

Meeting: 2019 American Transplant Congress

Abstract number: 136

Keywords: Graft survival, Kidney

Session Information

Session Name: Concurrent Session: Kidney: Pediatrics I

Session Type: Concurrent Session

Date: Sunday, June 2, 2019

Session Time: 4:30pm-6:00pm

 Presentation Time: 5:18pm-5:30pm

Location: Room 304

*Purpose: Paediatric donors have been contributing to the kidney donor pool but there are concerns regarding the small nephron mass, hyperfiltration, technical issues including risks of thrombosis and long-term outcomes. We present UK national outcomes data for these paediatric kidneys.

*Methods: Retrospective analysis of National Health Service Blood and Transfusion (NHSBT) database for paediatric kidney donors from 2007-2016. The cohort of paediatric donors was further divided into ≤ 5 and >5 years for analysis.

*Results: Total of 631 paediatric (<18 years) kidney transplants were performed in the study period (single and en-bloc).

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There were no statistical differences in the recipient age (36.0years v 35.9years), cold ischaemic times (14.2hours v 15.1hours) or the anastomotic times (39.1min v 38.8mins) between ≤ 5 and >5-year-old donor groups. The graft function (immediate, DGF or primary non-function rates) and the 12 months eGFRs (82.4 v 78.0) were also similar.

82.7% of the en-bloc kidney transplants were from ≤5 years old donors.

The graft survival rates were similar between the two donor age groups, between en-bloc and single kidney transplants and among donor types (DBD v DCD); overall and in single kidney groups. En-bloc DCD kidneys had worse graft survival (p 0.0007) compared to DBD donors.

*Conclusions: Paediatric kidney donors remain a precious source of renal allografts with excellent one-year eGFRs. Despite concerns, the outcomes from small (≤ 5 years old) paediatric donors are similar compared to older paediatric donors. Careful selection of donor and recipient is warranted when using en-bloc kidneys from small DCD donors.

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To cite this abstract in AMA style:

Khurram MA, Karydis N, Callaghan C, Loukopoulos I, Kasimatis T, Chandak P, Calder F, Mamode N, Kessaris N. United Kingdom National Outcomes of Transplants from Paediatric Donors: 10 Years Experience [abstract]. Am J Transplant. 2019; 19 (suppl 3). https://atcmeetingabstracts.com/abstract/united-kingdom-national-outcomes-of-transplants-from-paediatric-donors-10-years-experience/. Accessed May 9, 2025.

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