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Trends in Liver Transplantation in Patients with Renal Failure Since Implementation of Simultaneous Liver-Kidney Allocation Policy

P. J. Altshuler, O. Shaheen, A. P. Shah, J. Glorioso, A. Frank, C. Ramirez, W. Maley, A. S. Bodzin

Department of Surgery, Thomas Jefferson University, Philadelphia, PA

Meeting: 2020 American Transplant Congress

Abstract number: 40

Keywords: Cadaveric organs, Kidney, Liver, Renal failure

Session Information

Session Name: Liver: MELD, Allocation and Donor Issues (DCD/ECD) I

Session Type: Oral Abstract Session

Date: Saturday, May 30, 2020

Session Time: 3:15pm-4:45pm

 Presentation Time: 3:15pm-3:27pm

Location: Virtual

*Purpose: To reduce potentially unnecessary kidney utilization, as of August 10, 2017 a new allocation policy was implemented restricting Simultaneous Liver Kidney (SLK) transplant to patients meeting stringent criteria in acute or chronic renal failure. Here we evaluate the policy change by assessing one-year follow up results and its effects on number of transplants and outcomes.

*Methods: Retrospective review of the Organ Procurement and Transplantation Network database was performed for liver transplant recipients across two distinct two-year ranges – pre-allocation policy (August 2016-2017) and post-allocation policy implementation (August 2017-2018). Patient characteristics and transplant rates were compared across time periods for SLK and patients in renal failure receiving liver transplant alone (LTA). Outcomes related to patient survival, liver and kidney allograft function were reviewed.

*Results: SLK decreased by 14.2% from pre to post-policy implementation, while LTA in renal failure rose by 3.8% as demonstrated in Table 1. Baseline characteristics were similar across time periods for both SLK and LTA cohorts, as were outcomes related to 1-year patient and graft survival, and incidence of primary non-function. Renal allograft function in SLK demonstrated a non-statistically significant trend towards improvement in the post-implementation era. In total, SLK represented 9.32% of all liver transplants the year prior to SLK allocation policy implementation, and 7.94% post-implementation.

*Conclusions: Since adoption of the SLK allocation policy there has been a reversal in recent trends of rising SLK transplants. This has not come at the expense of patient, liver, or renal allograft function, as 1-year outcomes are similar across groups. Further long-term follow up and in-depth analyses of the consequences of the policy are needed to fully evaluate the impact on the liver transplant community.

Outcomes in SLK and LTA Recipients Pre and Post-Implementation of SLK Allocation Policy
SLK: Pre SLK Allocation SLK: Post SLK Allocation p-value LTA in Renal Failure: Pre SLK Allocation LTA in Renal Failure: Post SLK Allocation p-value
Number/(Total % of Liver Transplants) 754 (9.32%) 647 (7.94%) 2493 (30.82%) 2589 (31.78%)
Baseline: MELD 29.4 (23-36) 28.6 (22-34) 0.437 23 (21-38) 23 (32-38) 0.437
Dialysis Dependence 517 (68.57%) 460 (71.10%) 0322 617 (24.74%) 728 (28.11%) 0.007
Liver Outcomes: 1 year survival 678 (89.92%) 590 (91.19%) 0.465 2237 (89.73%) 2342 (90.46%) 0.398
1 year graft survival 670 (88.74%) 581 (89.66%) 0.606 2199 (88.17%) 2312 (89.27%) 0.231
Primary Non-Function 8 (1.06%) 6 (0.93%) 0.999 32 (1.28%) 23 (0.89%) 0.178
Kidney Outcomes: Graft Failure at 1 year 42 (5.56%) 27 (4.17%) 0.265

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To cite this abstract in AMA style:

Altshuler PJ, Shaheen O, Shah AP, Glorioso J, Frank A, Ramirez C, Maley W, Bodzin AS. Trends in Liver Transplantation in Patients with Renal Failure Since Implementation of Simultaneous Liver-Kidney Allocation Policy [abstract]. Am J Transplant. 2020; 20 (suppl 3). https://atcmeetingabstracts.com/abstract/trends-in-liver-transplantation-in-patients-with-renal-failure-since-implementation-of-simultaneous-liver-kidney-allocation-policy/. Accessed May 12, 2025.

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