Transversal Observational Study On Recurrent and Late Urinary Tract Infections (UTIs) in Renal Transplantation (tx)

G. Castellano,¹ M. Fiorentino,¹ M. Martino,¹ M. Rossini,¹ A. Schena,¹ C. Manno,¹ G. Grandaliano,² P. Ditonno,³ M. Battaglia,³ L. Gesualdo.¹

¹DETO, Nephrology, Dialysis and Transplantation Unit, University of Bari, Bari, Italy
²Department of Medical and Surgical Sciences, Nephrology, Dialysis and Transplantation Unit, University of Foggia, Foggia, Italy
³DETO, Andrology, Urology and Renal Transplantation Unit, University of Bari, Bari, Italy.

Meeting: 2015 American Transplant Congress

Abstract number: A74

Keywords: Bacterial infection, Graft function, Kidney transplantation

Session Information

Session Name: Poster Session A: Infection

Session Type: Poster Session

Date: Saturday, May 2, 2015

Session Time: 5:30pm-7:30pm

Presentation Time: 5:30pm-7:30pm

Location: Exhibit Hall E

UTIs are common complications after kidney tx. The aim of this study was to define the potential predisposing factors and the possible impact on graf function of sporadic late or recurrent UTIs.

We analysed 254 patients undergoing kidney tx, divided in two groups: group A (patients without UTIs or with early sporadic UTIs, 191 patients) and group B (late sporadic UTIs and recurrent UTIs, 63 patients). We performed Chi square test for dichotomous variables and with t-Student's test for continuous ones. Multivariate analysis was performed using logistic regression.

Group B presented an advanced mean age (50.2 vs. 46.1, p=0.023), an higher percentage of female (64% vs 34,7%, p<0.001) and polycystic disease (21.8% vs. 6.3%, p<0.001).

Main characteristics of study population
	GROUP A (n°190)	GROUP B (n°64)	p
AGE (years)	46,1 ± 12,3	50.2 ± 12.7	0.023
GENDER (M/F)	124/66	23/41	0.000
DIALYSIS (HD/PD)	156/34	57/7	0.191
POLICYSTIC DISEASE (%)	6.3%	21.8%	0.000
BMI (kg/m²)	24.88 ± 3.82	25.67 ± 4.92	0.219
DIABETES (%)	7.3%	12.5%	0.207
CMV INFECTIONS (%)	38.9%	51.5%	0.077
PRE-TX UROLOGICAL ABNORMALITIES (%)	8.9%	10.9%	0.638
POST-TX UROLOGICAL COMPLICATIONS (%)	7.3%	14%	0.107
DGF (%)	15.2%	18%	0.512
ACUTE REJECTION (%)	5.7%	10.9%	0.165

Interestingly, graft function at 36 months was significantly reduced in group B (mean Creat cl 82,4 vs. 63,8 ml/min, p = 0.002).

In the logistic regression analysis, the recurrent UTIs and the late UTIs were independent risk factors on graft outcome in terms of Creat cl < 60 ml/min at 36 months after tx (OR 2,953 95% CI 1,174 – 7,428, p=0.021).

In conclusion, the most common predisposing factors of UTIs were the female gender, the advanced age and polycystic disease (unchangeable factors). The recurrent UTIs and the late UTIs are independent risk factors for reduced graft function after tx.

To cite this abstract in AMA style:

Castellano G, Fiorentino M, Martino M, Rossini M, Schena A, Manno C, Grandaliano G, Ditonno P, Battaglia M, Gesualdo L. Transversal Observational Study On Recurrent and Late Urinary Tract Infections (UTIs) in Renal Transplantation (tx) [abstract]. Am J Transplant. 2015; 15 (suppl 3). https://atcmeetingabstracts.com/abstract/transversal-observational-study-on-recurrent-and-late-urinary-tract-infections-utis-in-renal-transplantation-tx/. Accessed November 21, 2024.

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