Session Time: 3:15pm-4:00pm
Presentation Time: 3:30pm-4:00pm
*Purpose: Considering westernized lifestyles and increasing prevalence of chronic diseases occurred in Korea, time-trend exploration of metabolic risk in live kidney donors may help to estimate the future long-term risk after kidney donation.
*Methods: Living kidney donors in seven hospitals from 1982 to 2016 were enrolled. As controls having similar health status to the donors, individuals voluntarily receiving health check-ups from 1995 to 2016 were included. After excluding individuals with estimated glomerular filtration rate (eGFR) <50 mL/min/1.73m2, diabetes, and cancer, living kidney donors and healthy populations were matched for age, sex, baseline eGFR and era. The percentage of hyperuricemia, systolic blood pressure (SBP) ≥140mmHg and body mass index (BMI) ≥25 kg/m2 were evaluated. To compare the trends of metabolic risks according to the era in the two groups, logistic regressions with interaction terms between the era and donor status were used.
*Results: A total of 2,051 living kidney donors and matched non-donors are included, respectively. The mean age was 42.8±11.1 years and 53.7% were female. Serum glucose and cholesterol level tended to increase in living kidney donors (P for trend <0.001). Hyperuricemia was constantly increased in both living donors (4.6% at 1995-2000, 5.9% in 2001-2006, 9.0% in 2007-2011, and 11.7% in 2012-2016) and healthy non-donors (7.1% in 1995-2000, 11.5% in 2001-2006, 11.8% in 2007-2011, and 17.3% in 2012-2016). The percentage of donors with SBP of more than 140 mmHg was consistent with 9%. However, in matched non-donors, individuals with SBP ≥140mmHg were increased after 2007-2011 (12.2% in 2007-2011). Overweight/obese population tended to increase for both kidney donors and matched non-donors since 2001 (live kidney donor 25.6% in 2001-2006 and 34.6% in 2012-2016 vs. non-donors 22.0% in 2001-2006 and 31.6% in 2012-2016). There were no differences in the trend of the metabolic risks including hyperuricemia, SBP≥140 mmHg, and BMI ≥25 kg/m2 between living kidney donors and matched non-donors.
*Conclusions: Metabolic risks represented by hyperuricemia, SBP≥140mmHg, and BMI ≥25 kg/m2 were increased over time although this is not specific findings for living kidney donors but in parallel with matched non-donor controls in South Korea.
To cite this abstract in AMA style:Kang E, Park J, Park S, Kim Y, Jeong J, An J, Lee S, Kim S, Cho J, Han M, Lee H. Time-Trend of Metabolic Risks in Living Kidney Donors in South Korea [abstract]. Am J Transplant. 2020; 20 (suppl 3). https://atcmeetingabstracts.com/abstract/time-trend-of-metabolic-risks-in-living-kidney-donors-in-south-korea/. Accessed September 22, 2020.
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