Time-Trend of Metabolic Risks in Living Kidney Donors in South Korea
1Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of, 2Internal Medicine, Keimyung University Dongsan Hospital, Daegu, Korea, Republic of, 3Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea, Republic of, 4Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea, Republic of, 5Internal Medicine, Chonbuk National University Hospital, Jeonju, Korea, Republic of, 6Internal Medicine, Chonnam National University Hospital, Gwangju, Korea, Republic of, 7Internal Medicine, Kyungpook National University, Seoul, Korea, Republic of, 8Internal Medicine, Pusan National University Hospital, Pusan, Korea, Republic of
Meeting: 2020 American Transplant Congress
Abstract number: A-032
Keywords: Donation, Kidney transplantation, Metabolic complications
Session Information
Session Name: Poster Session A: Kidney Living Donor: Other
Session Type: Poster Session
Date: Saturday, May 30, 2020
Session Time: 3:15pm-4:00pm
Presentation Time: 3:30pm-4:00pm
Location: Virtual
*Purpose: Considering westernized lifestyles and increasing prevalence of chronic diseases occurred in Korea, time-trend exploration of metabolic risk in live kidney donors may help to estimate the future long-term risk after kidney donation.
*Methods: Living kidney donors in seven hospitals from 1982 to 2016 were enrolled. As controls having similar health status to the donors, individuals voluntarily receiving health check-ups from 1995 to 2016 were included. After excluding individuals with estimated glomerular filtration rate (eGFR) <50 mL/min/1.73m2, diabetes, and cancer, living kidney donors and healthy populations were matched for age, sex, baseline eGFR and era. The percentage of hyperuricemia, systolic blood pressure (SBP) ≥140mmHg and body mass index (BMI) ≥25 kg/m2 were evaluated. To compare the trends of metabolic risks according to the era in the two groups, logistic regressions with interaction terms between the era and donor status were used.
*Results: A total of 2,051 living kidney donors and matched non-donors are included, respectively. The mean age was 42.8±11.1 years and 53.7% were female. Serum glucose and cholesterol level tended to increase in living kidney donors (P for trend <0.001). Hyperuricemia was constantly increased in both living donors (4.6% at 1995-2000, 5.9% in 2001-2006, 9.0% in 2007-2011, and 11.7% in 2012-2016) and healthy non-donors (7.1% in 1995-2000, 11.5% in 2001-2006, 11.8% in 2007-2011, and 17.3% in 2012-2016). The percentage of donors with SBP of more than 140 mmHg was consistent with 9%. However, in matched non-donors, individuals with SBP ≥140mmHg were increased after 2007-2011 (12.2% in 2007-2011). Overweight/obese population tended to increase for both kidney donors and matched non-donors since 2001 (live kidney donor 25.6% in 2001-2006 and 34.6% in 2012-2016 vs. non-donors 22.0% in 2001-2006 and 31.6% in 2012-2016). There were no differences in the trend of the metabolic risks including hyperuricemia, SBP≥140 mmHg, and BMI ≥25 kg/m2 between living kidney donors and matched non-donors.
*Conclusions: Metabolic risks represented by hyperuricemia, SBP≥140mmHg, and BMI ≥25 kg/m2 were increased over time although this is not specific findings for living kidney donors but in parallel with matched non-donor controls in South Korea.
To cite this abstract in AMA style:
Kang E, Park J, Park S, Kim Y, Jeong J, An J, Lee S, Kim S, Cho J, Han M, Lee H. Time-Trend of Metabolic Risks in Living Kidney Donors in South Korea [abstract]. Am J Transplant. 2020; 20 (suppl 3). https://atcmeetingabstracts.com/abstract/time-trend-of-metabolic-risks-in-living-kidney-donors-in-south-korea/. Accessed November 22, 2024.« Back to 2020 American Transplant Congress