The Outcome of Carbapenemase-Producing Enterobacteriaceae (CPE) Infection in Adult Solid Organ Transplant Population at a University Teaching Hospital
Transplant Surgery, Manchester Royal Infirmary, Manchester, United Kingdom.
Meeting: 2015 American Transplant Congress
Abstract number: B20
Keywords: Graft function, Infection
Session Information
Session Name: Poster Session B: Bacterial/Fungal/Other Infections
Session Type: Poster Session
Date: Sunday, May 3, 2015
Session Time: 5:30pm-6:30pm
Presentation Time: 5:30pm-6:30pm
Location: Exhibit Hall E
BACKGROUND:
Over the last decade CPE infection has been reported globally and is now endemic in healthcare facilities in many countries. There has been no report of the effect of CPE infection in Transplant population as yet. Therefore, we aimed to study the epidemiology and outcomes of CPE infection in our pancreatic-renal transplant unit.
METHOD:
All Transplant patients tested positive for CPE over last 10 years from Hospital CPE database were identified. Rapid CPE test was used to screen patients and CPE infection was defined as positive CPE culture from a subsequent clinical isolate. Hospital notes of CPE infection patients were retrospectively reviewed to identify risk factors of infection and transplant outcomes. Stats-direct version 3 was used for statistical calculation.
RESULTS:
272 patients were screened positive for CPE infection. 46/272 (17%) patients had subsequent positive clinical isolate requiring treatment.12/46 (26%) patients developed positive blood culture requiring IV antibiotics according to sensitivity. 09/46 (19%) of CPE isolated patients required ITU support. 02/46 (4%) patients with other multiple co-morbidities died. The incidence of CPE increased over last 3 years with the first patient identified in 2010; log increase was 266% in 2011, 162% in 2012, 138% in 2013 to expected 111% in 2014. The Interquartile age distribution of CPE infected patients was 32-81 years, 95% CI 49.2-57.9, p=0.20, with equal gender distribution. CPE infection was associated with prolonged hospital stay (> 15 days ) 95% CI 15.5-32.9 days, p<0.001 on multivariable linear regression model. CPE infection was not statistically associated with poor graft function (p=0.33). The death censored graft loss rate was 2%. (p=0.12)
CONCLUSION:
Prolonged hospital stay is associated to CPE infection. Urgent preventive steps like hand washing, early hospital discharge may minimize the infection risk. More experience is required to augment our strategies to control CPE infection rate.
To cite this abstract in AMA style:
Sharma H, El-Bakry A, Venkat V, Papachristos S, Otilla P, Dhanda R, Forgacs B, Tavakoli A, Pararajasingam R. The Outcome of Carbapenemase-Producing Enterobacteriaceae (CPE) Infection in Adult Solid Organ Transplant Population at a University Teaching Hospital [abstract]. Am J Transplant. 2015; 15 (suppl 3). https://atcmeetingabstracts.com/abstract/the-outcome-of-carbapenemase-producing-enterobacteriaceae-cpe-infection-in-adult-solid-organ-transplant-population-at-a-university-teaching-hospital/. Accessed May 19, 2025.« Back to 2015 American Transplant Congress