The Effect of Pre-Transplant Insomnia and Post-Transplant Insomnia on Survival among Solid Organ Recipients

K-.F. Lee,² Y. Tsai,¹ C. Lin,¹ C-.B. Hsieh,^3,5 S. Wu,⁴ T. Chen,⁵ Y-.C. Lin,¹ W-.H. Lee,^6,7 F. Lin,⁸ C. Tsai.^1,9,10

¹Cardiovascular Surgery, Tri-Service General Hospital, Taipei, Taiwan
²Biobank Management Center, Tri-Service General Hospital, Taipei, Taiwan
³General Surgery, Hualien Armed Forces General Hospital, Hualien County, Taiwan
⁴Urology, Tri-Service General Hospital, Taipei, Taiwan
⁵General Surgery, Tri-Service General Hospital, Taipei, Taiwan
⁶Pathology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
⁷Pathology, Taipei Medical University-Shuang Ho Hospital, New Taipei, Taiwan
⁸Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
⁹Cardiovascular Surgery, Taoyuan Armed Forces General Hospital, Taoyuan, Taiwan
¹⁰Graduate Institute of Pharmacology, National Defense Medical Center, Taipei, Taiwan.

Meeting: 2018 American Transplant Congress

Abstract number: B333

Keywords: Heart transplant patients, Kidney transplantation, Liver transplantation, Survival

Session Information

Session Name: Poster Session B: Non-Organ Specific: Economics, Public Policy, Allocation, Ethics

Session Type: Poster Session

Date: Sunday, June 3, 2018

Session Time: 6:00pm-7:00pm

Presentation Time: 6:00pm-7:00pm

Location: Hall 4EF

Background

Because studies about insomnia among organ recipients were scarce, we used National Health Insurance Research Database (NHIRD) between 2001 and 2012 to understand how pre-transplant and post-transplant insomnia effect on the survival among solid organ recipients.

Methods

National Health Insurance program is compulsory for all citizens in Taiwan. Insomnia was defined by International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) 307.41, 307.42 or 780.52 with great than or equal to 3 times on records of outpatient visits or hospitalizations. In this study, 5853 patients received heart, kidney or liver transplantation from 2001 to 2011 with a follow-up ≥ 1 month. Kaplan-Meier analysis was used for survival and log-rank test were calculated for comparisons.

Results

5853 recipients were analyzed and 297 patients (5.1%) were pre-transplant insomnia, 260 recipients (4.4%) were post-transplant insomnia and the rest (90.5%) was insomnia free. Among solid organ recipients, those with post-transplant insomnia had better survival than pre-transplant insomnia and insomnia free (p<0.001). Both pre-transplant insomnia and insomnia free group had similar outcome (p=0.65). We also found same results among kidney (p<0.001) and liver (p=0.01) recipients but no significant difference on heart patients (p=0.17).

Conclusion

Recipients with post-transplant insomnia had better survival than pre-transplant insomnia and insomnia free. Patients with pre-transplant insomnia and insomnia free group had similar survival. These phenomenon also could be found in kidney and liver transplantations.

CITATION INFORMATION: Lee K-.F., Tsai Y., Lin C., Hsieh C-.B., Wu S., Chen T., Lin Y-.C., Lee W-.H., Lin F., Tsai C. The Effect of Pre-Transplant Insomnia and Post-Transplant Insomnia on Survival among Solid Organ Recipients Am J Transplant. 2017;17 (suppl 3).

To cite this abstract in AMA style:

Lee K-F, Tsai Y, Lin C, Hsieh C-B, Wu S, Chen T, Lin Y-C, Lee W-H, Lin F, Tsai^{1 C. The Effect of Pre-Transplant Insomnia and Post-Transplant Insomnia on Survival among Solid Organ Recipients [abstract].

https://atcmeetingabstracts.com/abstract/the-effect-of-pre-transplant-insomnia-and-post-transplant-insomnia-on-survival-among-solid-organ-recipients/. Accessed June 1, 2025.}

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