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Sirolimus (SRL) versus Everolimus (EVR) versus Mycophenolate (MPA) in Kidney Transplant Recipients Receiving Anti-Thymocyte Globulin Induction (r-ATG), Tacrolimus (TAC), and Prednisone

H. Tedesco Jr., C. T. Felipe, L. Viana, M. Cristelli, N. Tenório, V. Lima, V. Azevedo, K. Ficher, J. Rezende, R. Demarchi, M. Nakamura, Y. Dreige, G. Ormenesse, J. Taddedo, L. Takara, C. Santos, L. Damasceno, J. Pestana

Nephrology Division, Hospital Do Rim, Sao Paulo, Brazil

Meeting: 2020 American Transplant Congress

Abstract number: D-006

Keywords: Kidney transplantation

Session Information

Date: Saturday, May 30, 2020

Session Name: Poster Session D: Kidney Immunosuppression: Induction Therapy

Session Time: 3:15pm-4:00pm

 Presentation Time: 3:30pm-4:00pm

Location: Virtual

Related Abstracts
  • Sirolimus (SRL) versus Everolimus (EVR) versus Mycophenolate (MPA) in Kidney Transplant Recipients Receiving Anti-Thymocyte Globulin Induction (r-ATG), Tacrolimus (TAC), and Prednisone
  • Everolimus (EVR) versus Mycophenolate Sodium (MPS) for Recipients of Kidney Transplants from Expanded Criteria Donors (ECD) Receiving Anti-Thymocyte Globulin (r-ATG) and Tacrolimus (TAC).

*Purpose: The aim of this study is to compare the efficacy and safety of SRL versus EVR versus MPA in kidney transplant recipients

*Methods: This is an ongoing single center, prospective and randomized trial in kidney transplant recipients receiving a single 3 mg/kg dose of r-ATG induction therapy, tacrolimus and faster prednisone taper (Clinicaltrials.govNCT03468478). Randomized patients receive SRL (3 mg QD adjusted to maintain concentrations between 4 to 8 ng/mL), EVR (3 mg BID adjusted to maintain concentrations between 4 to 8ng/mL), or MPA (720 mg BID). All patients received preemptive treatment for CMV infection

*Results: This preliminary analysis includes data from the first 246 kidney transplants recipients receiving SRL (n=81), EVR (n=83), or MPA (n=82). Key efficacy and safety outcomes are shown in Table. The incidence of CMV infection/disease is higher in the MPA group but there is no difference in the incidence of biopsy proven acute rejection (BPAR) and in mean estimated glomerular filtration rate (eGFR) at month 12.

*Conclusions: These preliminary data suggest that comparable mTOR inhibitor exposures show similar efficacy compared to MPA and lower incidence of viral infection.

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To cite this abstract in AMA style:

Jr HTedesco, Felipe CT, Viana L, Cristelli M, Tenório N, Lima V, Azevedo V, Ficher K, Rezende J, Demarchi R, Nakamura M, Dreige Y, Ormenesse G, Taddedo J, Takara L, Santos C, Damasceno L, Pestana J. Sirolimus (SRL) versus Everolimus (EVR) versus Mycophenolate (MPA) in Kidney Transplant Recipients Receiving Anti-Thymocyte Globulin Induction (r-ATG), Tacrolimus (TAC), and Prednisone [abstract]. Am J Transplant. 2020; 20 (suppl 3). https://atcmeetingabstracts.com/abstract/sirolimus-srl-versus-everolimus-evr-versus-mycophenolate-mpa-in-kidney-transplant-recipients-receiving-anti-thymocyte-globulin-induction-r-atg-tacrolimus-tac-and-prednisone-2/. Accessed March 3, 2021.

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