Significance of Time-Zero Biopsy Findings for Deceased Donor Kidney Transplantation, The
Department of Surgery, Yonsei University College of Medicine, Seoul, Korea
Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea
Department of Pathology, Yonsei University College of Medicine, Seoul, Korea
Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
Department Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Korea
Meeting: 2013 American Transplant Congress
Abstract number: D1541
Introduction: Donor organ qualities from deceased donors affect graft survival after kidney transplantation, especially for marginal donors. The authors considered that relations between donor-related factors and histological findings might provide useful information regarding early graft outcomes.
Patients and Methods: Between December 2006 and July 2011, 135 recipients of deceased donor kidneys were included, and data concerning donor-related clinical characteristics and histological findings of time-zero biopsies categorized using Banff criteria were included in the analysis.
Results: Mean age of deceased donors was 44.3±12.34 years. Global glomerulosclerosis (GS, 38.5%), tubular atrophy (CT, 37.8%), interstitial fibrosis (CI, 23%), vascular fibrous intimal thickening (CV, 21.5%), arteriolar hyaline thickening (AH, 25.9%), interstitial inflammation (I, 20%) were the major pathologic findings of time-zero biopsies. A multivariate logistic regression analysis showed terminal donor creatinine level, a recipient history of diabetes, and AH was significantly independent predictors of delayed graft function. The only independent risk factor of a decrease of eGFR at 1 year was interstitial fibrosis.
| eGFR at 6month | eGFR at 1year | |||
| parameter | B (SE) | p-value | B (SE) | p-value |
| Donor clinical | ||||
| Age | -4.03 (1.28) | 0.002 | -2.56 (1.32) | 0.055 |
| History of diabetes | 1.79 (6.54) | 0.785 | ||
| Use of inotropics | -14.72 (6.04) | 0.016 | ||
| Histological | ||||
| Glomerulosclerosis (GS) | -0.82 (1.84) | 0.655 | 0.10 (1.86) | 0.957 |
| Tubular atrophy (CT) | 3.80 (4.30) | 0.377 | 5.86 (4.45) | 0.195 |
| Interstitial fibrosis (CI) | -8.22 (4.85) | 0.092 | -12.36 (5.06) | 0.016 |
| Arteriolar hyaline thickening (AH) | -9.96 (4.01) | 0.014 | -7.63 (4.00) | 0.059 |
| Interstitial inflammation (I) | -6.45 (4.44) | 0.149 | -7.60 (4.58) | 0.100 |
Conclusion: Considerations of clinico-histological findings were found to be valuable for predicting early graft outcome after deceased donor kidney transplantation.
To cite this abstract in AMA style:
Lee A, Kim M, Jeong H, Joo D, Lee S, Kim B, Huh K, Kim Y, Park K. Significance of Time-Zero Biopsy Findings for Deceased Donor Kidney Transplantation, The [abstract]. Am J Transplant. 2013; 13 (suppl 5). https://atcmeetingabstracts.com/abstract/significance-of-time-zero-biopsy-findings-for-deceased-donor-kidney-transplantation-the/. Accessed January 17, 2021.« Back to 2013 American Transplant Congress