ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Advanced Search

Significance of Time-Zero Biopsy Findings for Deceased Donor Kidney Transplantation, The

A. Lee, M. Kim, H. Jeong, D. Joo, S. Lee, B. Kim, K. Huh, Y. Kim, K. Park

Department of Surgery, Yonsei University College of Medicine, Seoul, Korea
Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea
Department of Pathology, Yonsei University College of Medicine, Seoul, Korea
Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
Department Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Korea

Meeting: 2013 American Transplant Congress

Abstract number: D1541

Related Abstracts
  • Arterial Blood Pressure at Time of Liver Transplant (LT) Evaluation Correlates With Kidney Biopsy Findings in LT Candidates With Renal Dysfunction
  • Kidney Donor Risk Index Is a Good Prognostic Tool for Graft Outcomes in Deceased-Donor Kidney Transplantation with Short, Cold Ischemic Time

Introduction: Donor organ qualities from deceased donors affect graft survival after kidney transplantation, especially for marginal donors. The authors considered that relations between donor-related factors and histological findings might provide useful information regarding early graft outcomes.

Patients and Methods: Between December 2006 and July 2011, 135 recipients of deceased donor kidneys were included, and data concerning donor-related clinical characteristics and histological findings of time-zero biopsies categorized using Banff criteria were included in the analysis.

Results: Mean age of deceased donors was 44.3±12.34 years. Global glomerulosclerosis (GS, 38.5%), tubular atrophy (CT, 37.8%), interstitial fibrosis (CI, 23%), vascular fibrous intimal thickening (CV, 21.5%), arteriolar hyaline thickening (AH, 25.9%), interstitial inflammation (I, 20%) were the major pathologic findings of time-zero biopsies. A multivariate logistic regression analysis showed terminal donor creatinine level, a recipient history of diabetes, and AH was significantly independent predictors of delayed graft function. The only independent risk factor of a decrease of eGFR at 1 year was interstitial fibrosis.

Table 1: Multivariate analysis of eGFR at 6 months and 1 year
  eGFR at 6month eGFR at 1year
parameter B (SE) p-value B (SE) p-value
Donor clinical        
Age -4.03 (1.28) 0.002 -2.56 (1.32) 0.055
History of diabetes 1.79 (6.54) 0.785    
Use of inotropics -14.72 (6.04) 0.016    
Histological        
Glomerulosclerosis (GS) -0.82 (1.84) 0.655 0.10 (1.86) 0.957
Tubular atrophy (CT) 3.80 (4.30) 0.377 5.86 (4.45) 0.195
Interstitial fibrosis (CI) -8.22 (4.85) 0.092 -12.36 (5.06) 0.016
Arteriolar hyaline thickening (AH) -9.96 (4.01) 0.014 -7.63 (4.00) 0.059
Interstitial inflammation (I) -6.45 (4.44) 0.149 -7.60 (4.58) 0.100
SE; standard error, Donor ages were categorized as <34, 35-44, 45-54, and ≥55 years

Conclusion: Considerations of clinico-histological findings were found to be valuable for predicting early graft outcome after deceased donor kidney transplantation.

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Lee A, Kim M, Jeong H, Joo D, Lee S, Kim B, Huh K, Kim Y, Park K. Significance of Time-Zero Biopsy Findings for Deceased Donor Kidney Transplantation, The [abstract]. Am J Transplant. 2013; 13 (suppl 5). https://atcmeetingabstracts.com/abstract/significance-of-time-zero-biopsy-findings-for-deceased-donor-kidney-transplantation-the/. Accessed January 17, 2021.

« Back to 2013 American Transplant Congress

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Penis Transplantation: First U.S. Experience.
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Live Related Kidney Transplant Experience in Abuja, Nigeria – First Eight Cases Ever.
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Penis Transplantation: First U.S. Experience.
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Kidney Dialysis after Heart Transplantation: The Short and Long Term Outcomes
  • Penis Transplantation: First U.S. Experience.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Evidence of a Clinically Significant Drug-Drug Interaction between Cannabidiol and Tacrolimus: A Case Report
  • Kidney Dialysis after Heart Transplantation: The Short and Long Term Outcomes

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2021 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy

loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.