Introduction: Donor organ qualities from deceased donors affect graft survival after kidney transplantation, especially for marginal donors. The authors considered that relations between donor-related factors and histological findings might provide useful information regarding early graft outcomes.
Patients and Methods: Between December 2006 and July 2011, 135 recipients of deceased donor kidneys were included, and data concerning donor-related clinical characteristics and histological findings of time-zero biopsies categorized using Banff criteria were included in the analysis.
Results: Mean age of deceased donors was 44.3±12.34 years. Global glomerulosclerosis (GS, 38.5%), tubular atrophy (CT, 37.8%), interstitial fibrosis (CI, 23%), vascular fibrous intimal thickening (CV, 21.5%), arteriolar hyaline thickening (AH, 25.9%), interstitial inflammation (I, 20%) were the major pathologic findings of time-zero biopsies. A multivariate logistic regression analysis showed terminal donor creatinine level, a recipient history of diabetes, and AH was significantly independent predictors of delayed graft function. The only independent risk factor of a decrease of eGFR at 1 year was interstitial fibrosis.
|eGFR at 6month||eGFR at 1year|
|parameter||B (SE)||p-value||B (SE)||p-value|
|Age||-4.03 (1.28)||0.002||-2.56 (1.32)||0.055|
|History of diabetes||1.79 (6.54)||0.785|
|Use of inotropics||-14.72 (6.04)||0.016|
|Glomerulosclerosis (GS)||-0.82 (1.84)||0.655||0.10 (1.86)||0.957|
|Tubular atrophy (CT)||3.80 (4.30)||0.377||5.86 (4.45)||0.195|
|Interstitial fibrosis (CI)||-8.22 (4.85)||0.092||-12.36 (5.06)||0.016|
|Arteriolar hyaline thickening (AH)||-9.96 (4.01)||0.014||-7.63 (4.00)||0.059|
|Interstitial inflammation (I)||-6.45 (4.44)||0.149||-7.60 (4.58)||0.100|
Conclusion: Considerations of clinico-histological findings were found to be valuable for predicting early graft outcome after deceased donor kidney transplantation.
To cite this abstract in AMA style:Lee A, Kim M, Jeong H, Joo D, Lee S, Kim B, Huh K, Kim Y, Park K. Significance of Time-Zero Biopsy Findings for Deceased Donor Kidney Transplantation, The [abstract]. Am J Transplant. 2013; 13 (suppl 5). https://atcmeetingabstracts.com/abstract/significance-of-time-zero-biopsy-findings-for-deceased-donor-kidney-transplantation-the/. Accessed May 17, 2021.
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