Risk of Venous Thromboembolism After Lung Transplant.
1William S. Middleton Memorial Veterans Hospital, Madison, WI
2UW Health, Madison, WI
3University of Wisconsin School of Pharmacy, Madison, WI
Meeting: 2017 American Transplant Congress
Abstract number: B262
Keywords: Anticoagulation, Lung transplantation, Mortality, Post-operative complications
Session Information
Session Name: Poster Session B: Lung Transplantation Poster Session
Session Type: Poster Session
Date: Sunday, April 30, 2017
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall D1
Purpose
Venous thromboembolism (VTE) is a significant cause of morbidity and mortality following lung transplantation. The purpose of this study was to describe the incidence of VTE overall and within the first year after transplant.
Methods
A retrospective chart review of primary lung transplant recipients from January 1, 2000 to May 31, 2014 was performed. Event data were collected through July 31, 2014. Risk factors and clinical information at time of transplant and time of VTE were collected.
Results
A total of 438 patients were included in the study with 137 patients transplanted before implementation of the Lung Allocation Score (LAS) on May 4, 2005 and 301 patients transplanted post-LAS. Demographic characteristics including BMI, universal DVT prophylaxis, single versus bilateral transplant, and use of cardiopulmonary bypass in the VTE and the non-VTE groups were similar, except idiopathic pulmonary fibrosis was more common among patients with VTE in the first year. The overall incidence of VTE following lung transplant during the study period was 19.4%, with 9.6% patients having DVT only. The incidence of VTE in the first year and the first 90 days post-transplant was 14.3% and 10.5%, respectively. There was an increased risk of VTE in the first year for those transplanted post-LAS implementation (OR 3.61; 95% CI, 1.67 – 7.80; p=0.001) as well as an increased risk of VTE in the first 90 days after surgery post-LAS (OR 3.35; 95% CI 1.38 – 8.09; p equals 0.005). The risk of VTE was higher in the first 90 days versus days 91 to 365 (OR 2.59; 9% CI 1.46 – 4.60; p=0.001) for both groups. While overall occurrence of VTE did not affect survival, patients who had a VTE in the first year had lower survival compared to patients who did not (p < 0.0001).
Conclusion
Since implementation of the LAS, an increased incidence of VTE in the first year after lung transplantation was observed. The increased risk of VTE in the first year after transplant and resultant increased mortality warrants investigation of strategies for longer post-surgical VTE prophylaxis.
CITATION INFORMATION: Felkner R, Condon A, Rolling K, Hayney M. Risk of Venous Thromboembolism After Lung Transplant. Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:
Felkner R, Condon A, Rolling K, Hayney M. Risk of Venous Thromboembolism After Lung Transplant. [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/risk-of-venous-thromboembolism-after-lung-transplant/. Accessed June 14, 2025.« Back to 2017 American Transplant Congress