Session Time: 3:15pm-4:00pm
Presentation Time: 3:30pm-4:00pm
*Purpose: Focal segmental glomerulosclerosis (FSGS) is one of the most common causes of end stage renal diseases (ESRD) in children. Many pediatric patients diagnosed with FSGS are resistant to treatment and eventually need dialysis and kidney transplantation. After renal transplant, there is a high percentage of FSGS recurrence. The aim of this study was to evaluate risk factors of FSGS recurrence in pediatric renal transplant recipients in Korea.
*Methods: Pediatric patients diagnosed with FSGS who underwent kidney transplantation from January 2000 to December 2017 from a single center were included in this retrospective review. Demographic and FSGS related factors were compared and analyzed between the group with no FSGS recurrence and the group that developed FSGS recurrence. FSGS recurrence was defined as nephrotic range proteinuria after transplantation.
*Results: Out of 62 FSGS pediatric patients who underwent 66 renal transplants, thirteen patients (19%) presented with FSGS recurrence. The duration from diagnosis of FSGS to progression of ESRD was significantly associated with FSGS recurrence (p < 0.05). The patients who developed FSGS recurrence were significantly associated with the absence of induction therapy and cyclosporine over tacrolimus as the choice of immunosuppressants (p < 0.05). Interestingly, patients who had undergone previous treatment of FSGS were significantly associated with FSGS recurrence (p < 0.05). However, in a multivariate analysis, the duration from diagnosis to ESRD was the only independent risk factor associated with FSGS recurrence (p < 0.05).
*Conclusions: When FSGS pediatric patients are resistant to treatment and progresses to ESRD, early decision for kidney transplantation as an treatment option may have a lesser risk of FSGS recurrence after transplant. Further large prospective studies of the recurrence of FSGS after kidney transplantation and its risk factors are needed for future pediatric kidney transplant recipients.
To cite this abstract in AMA style:Chung CT, Ko H, Mo H, Kim H, Han A, Min S, Ha J. Risk Factors of Focal Segmental Glomerulosclerosis Recurrence in Pediatric Kidney Transplant Recipients : Single Center Experience [abstract]. Am J Transplant. 2020; 20 (suppl 3). https://atcmeetingabstracts.com/abstract/risk-factors-of-focal-segmental-glomerulosclerosis-recurrence-in-pediatric-kidney-transplant-recipients-single-center-experience/. Accessed April 15, 2021.
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