ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2022 American Transplant Congress
    • 2021 American Transplant Congress
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2021 Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Search

Risk Factors of De Novo Malignancies after Liver Transplantation

M. Altieri,1 O. Seree,2 J. Dumortier,3 GREF2 Groupe de Recherche Français en Greffe de Foie.

1Service d'HepatoGastroenterologie, Nutrition et Oncologie Digestive, CHU de Caen, Caen, France
2Réseau Régional de Cancérologie Onco-Basse-Normandie, Herouville Saint-Clair, France
3Service d'HepatoGastroenterologie, Hospices Civils de Lyon, Hôpital de la Croix Rousse, Lyon, France.

Meeting: 2018 American Transplant Congress

Abstract number: B276

Keywords: Liver cirrhosis, Liver grafts, Malignancy

Session Information

Session Name: Poster Session B: Liver: Hepatocellular Carcinoma and Other Malignancies

Session Type: Poster Session

Date: Sunday, June 3, 2018

Session Time: 6:00pm-7:00pm

 Presentation Time: 6:00pm-7:00pm

Location: Hall 4EF

De novo malignancies after liver transplantation (LT) are one of the leading causes of late mortality, with a reported risk of malignancies twice as high as the general population. The aim of the present study was to study predictive factors of de novo malignancies in a large cohort of LT recipients in France.

This population-based cohort study included all adult patients who underwent a first LT in France from January 1, 2000 to December 31, 2013. For cancer, an extension of the Cox model adapted to the identification of predictive factors in a context of competitive risks was used.

The study cohort included 11004 adult transplant recipients between 2000 and 2013 who had never had pre-transplant cancer except HCC. From the entire cohort, one (or more) de novo malignancy was reported in 1480 LT recipients (13.45%).

The median age of patients without malignancy was 53.8 years, and the median age of patients with malignancy was 54.2 years. The median (interquartile) duration of follow-up was 3.55 (1.04-7.18) years for patients with no malignancy and 3.59 (1.10-7.04) years for patients developing malignancy. LTs performed with an alcoholic cirrhosis aetiology accounted for 38.8% of LT causes in cancer patients versus 31.8% in TH that did not develop cancer. We observed a significant increase in risk of cancer Subdistribution Hazard Ratio (SHR) = 1.03 and Death Hazard Ratio (HR) = 1.02 with age. Women have a significantly lower risk of reporting post LT cancer. The initial diseases Alcoholic cirrhosis, autoimmune, other cirrhosis and hepatic tumours have a significantly higher risk of developing cancer. Regarding treatments, there is no significant difference between the different treatments of each class on the occurrence of de novo cancer. Regarding treatments, there is no significant difference between the different treatments of each class on the occurrence of de novo cancer.

In conclusion, age, sex, OH cirrhosis, autoimmune disease, other cirrhosis, and hepatic tumor of TH were risk factors of post-LT de novo malignancies and age, sex, metabolic disease, anti-cell antibodies and retransplantations were associated with poorer survival.

CITATION INFORMATION: Altieri M., Seree O., Dumortier J., GREF2 Groupe de Recherche Français en Greffe de Foie Risk Factors of De Novo Malignancies after Liver Transplantation Am J Transplant. 2017;17 (suppl 3).

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

To cite this abstract in AMA style:

Altieri M, Seree O, Dumortier J. Risk Factors of De Novo Malignancies after Liver Transplantation [abstract]. https://atcmeetingabstracts.com/abstract/risk-factors-of-de-novo-malignancies-after-liver-transplantation/. Accessed June 5, 2025.

« Back to 2018 American Transplant Congress

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2025 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy | Terms of Use | Cookie Preferences