Risk Factors for Early Post Transplant Cardiac Dysfunction After Liver Transplantation

V. Subramanian¹, K. Bowers², H. Kalagotla², J. Buggs¹, N. Kemmer¹, K. Dhanireddy¹

¹Transplant Institute, Tampa General Hospital, Tampa, FL, ²University of South Florida, Tampa, FL

Meeting: 2022 American Transplant Congress

Abstract number: 873

Keywords: Heart failure, Liver transplantation, Outcome, Post-operative complications

Topic: Clinical Science » Liver » 55 - Liver: Recipient Selection

Session Information

Session Name: Liver: Recipient Selection

Session Type: Poster Abstract

Date: Saturday, June 4, 2022

Session Time: 5:30pm-7:00pm

Presentation Time: 5:30pm-7:00pm

Location: Hynes Halls C & D

*Purpose: Cardiovascular complications after liver transplantation (LTx) are a leading cause of morbidity and mortality. The goal of this study was to evaluate risk factors that predict early (within first 6 months) cardiac dysfunction (CD) after LTx.

*Methods: Retrospective analysis of adult LTx performed at our institution between 1/1/2018 and 12/31/2020. Data was collected both pre-transplant and during the first 6 month LTx period. Statistical analysis including survival and multivariate analysis were performed.

*Results: 367 LTx recipients were included in the study. Early post LTx CD was seen in 92 patients (25.1%). Post-LTx CD was defined as either drop in ejection fraction (EF) >10% (10.6% patients), systolic or diastolic failure (3.3%), or post LTx arrythmia (19.9%). Patients who developed early CD were older (59 vs 54 yrs, p=0.001), had pre-LTx episodes of arrythmia (28.9% vs 9.7%, p<0.001), left ventricular hypertrophy pre LTx (39.1% vs 27.3%, p=0.032). Post LTx CD resulted in significantly increased morbidity with increased ICU transfer, re-intubation, infections and other post LTx complications (all p<0.05). Post LTx CD significantly decreased post LTx survival (p<0.001, figure). On multivariate analysis - age (HR 1.04, p0.014), pre-LTx arrythmia (HR 2.721, p=0.006), pre-LTx dialysis (HR 2.1, p=0.009) were noted as risk factors for development of post LTx CD.

*Conclusions: Early post LTx CD leads to significant morbidity and post LTx graft and patient loss. Age, pre-LTx arrythmia and renal dysfunction were associated with early post LTx cardiac dysfunction.

To cite this abstract in AMA style:

Subramanian V, Bowers K, Kalagotla H, Buggs J, Kemmer N, Dhanireddy K. Risk Factors for Early Post Transplant Cardiac Dysfunction After Liver Transplantation [abstract]. Am J Transplant. 2022; 22 (suppl 3). https://atcmeetingabstracts.com/abstract/risk-factors-for-early-post-transplant-cardiac-dysfunction-after-liver-transplantation/. Accessed November 21, 2024.

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