Background: Renal transplant is the optimal treatment for children with end-stage renal disease (ESRD). Most centers require a minimum weight of about 10 kg for transplantation. However, this may result in months of additional wait time, with prolonged associated risk.

Objective:We compared the outcomes of children weighing between 8 to 10kg at time of transplant to those weighing 10 to 13 kg to assess the risk associated with low-weight transplantation.

Methods: A retrospective analysis of transplants between January 2000-March 2014 was conducted using the UNOS database. Baseline characteristics and transplant outcomes of children 8-10 kg were compared to those 10-13 kg. Baseline characteristics were compared using t-test for continuous variables and X² for categorical variables. Outcomes were evaluated using X² and Cox regression. Outcome variables were delayed graft function, acute rejection at 6 months and 1 year, and graft failure at 1 and 5 years.

Results: Of 1049 children, 245 (23%) were under 10kg and 804 (77%) were 10-13 kg. There were no significant differences in gender, race, donor source (living or deceased), or underlying disease (glomerular/systemic vs. structural).

There was no significant difference in frequency of delayed function, thrombosis, acute rejection or graft failure at 1 and 5 years between the groups.

In regression analysis, no significant differences in 1 and 5 year rates of graft failure were identified between the weight groups when controlled for age, height, gender, race, donor source, pre-transplant dialysis and cause of renal failure.

Conclusion: There was no significant difference in measured outcomes between children who received kidney transplants at 8 to <10 kg compared to children 10-13kg.

CITATION INFORMATION: Singer P., Tseng Y., Sethna C., Castellanos-Reyes L., Molmenti E., Fahmy A., Grodstein E., Teperman L. Renal Transplant Outcomes in Recipients Weighing 8-10 Kilograms Am J Transplant. 2017;17 (suppl 3).

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