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Renal Outcomes in Prediabetic Living Kidney Donors Are Very Similar to Normoglycemic Donors at 10 Years Post-Donation

S. Chandran, U. Masharani, A. Webber, D. Wojciechowski

UCSF, San Francisco

Meeting: 2013 American Transplant Congress

Abstract number: 73

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Background

Potential living kidney donors with prediabetes are often excluded due to concerns about the development of diabetes and progression to ESRD. This strategy may be unnecessarily restrictive.

Methods

We conducted a single center retrospective study of living kidney donors from 1996-2007 with serum glucose >100 mg/dl (impaired fasting glucose or IFG). Donors with normal fasting glucose (NFG) matched for age, sex and year of donation were identified as controls. A medical history questionnaire was administered and blood and urine specimens obtained from donors who were successfully contacted and agreed to participate. Continuous variables were analyzed using the t-test and categorical variables were analyzed using Chi-square or Fisher's exact test.

Results

45 prediabetic donors and 45 normal controls were enrolled. Pre-donation characteristics are listed in table 1.

Predonation Characteristics
  IFG Donors, n=45 NFG Donors, n=45 p value
Male (%) 19 (42.2) 20 (44.4) ns
Age, yrs (SD) 47.1 (11.5) 47.5 (10.4) ns
Race (%)     ns
– Caucasian 29 (64.4) 26 (57.8)  
– African American 2 (4.4) 2 (4.4)  
– Other 14 (31.1) 17 (37.8)  
Family history of type 2 diabetes (%) 11 (24.4) 10 (22.2) ns
BMI, kg/sq m (SD) 28.1 (3.9) 25.3 (4.5) 0.0022
Mean fasting plasma glucose, mg/dl (SD) 108.9 (9.4) 87.1 (7.1) 0.0001
BP, mm Hg (SD)     ns
– Systolic 129 (13.3) 123.9 (14.9)  
– Diastolic 74.2 (8.7) 70.4 (9.9)  
MDRD eGFR 30 d post-donation (SD) 60.8 (10.8) 59.3 (11) ns

At study enrollment, mean time from donation was around 10 years for both groups. Medical history and laboratory data are listed in Table 2.

Post-donation Data
  IFG Donors, n=45 NFG Donors, n=45 p value
Age, yrs (SD) 57.4 (12.1) 57.4 (10.9) ns
Mean time from donation, yrs (SD) 10.4 (3.2) 10.0 (3.1) ns
BMI, kg/sq m (SD) 27.9 (4.9) 25.9 (5.1) 0.0539
History      
– Diabetes (%) yes 7 (15.6) 1 (2.2) 0.0582
– High blood pressure (%) yes 15 (34.3) 10 (22.2) ns
Mean fasting plasma glucose, mg/dl (SD) 104.7 (33.2) 90.0 (6.5) 0.0045
– <100 mg/dl (%) n=27 (60) n=43 (95.6)  
– 100 to 125 mg/dl (%) n=15 (33.3) n=2 (4.4)  
– >125mg/dl n=3 (6.7) n=0  
MDRD eGFR (SD) 70.7 (16.1) 67.3 (16.6) ns
Mean urine albumin/cr, mg/g (SD) 9.7 (26.6) 5.9 (11.0) ns
– 30 to 300 mg/g n=2 n=2  
– >300 mg/g n=0 n=0  
Triglycerides, mg/dl (SD) 130.6 (81.4) 111.3 (55.3) ns

Conclusions

Only a minority (15.6%) of donors with IFG had developed diabetes at 10 years post-donation. Kidney function

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To cite this abstract in AMA style:

Chandran S, Masharani U, Webber A, Wojciechowski D. Renal Outcomes in Prediabetic Living Kidney Donors Are Very Similar to Normoglycemic Donors at 10 Years Post-Donation [abstract]. Am J Transplant. 2013; 13 (suppl 5). https://atcmeetingabstracts.com/abstract/renal-outcomes-in-prediabetic-living-kidney-donors-are-very-similar-to-normoglycemic-donors-at-10-years-post-donation/. Accessed April 18, 2021.

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