Renal Outcomes in Prediabetic Living Kidney Donors Are Very Similar to Normoglycemic Donors at 10 Years Post-Donation
UCSF, San Francisco
Meeting: 2013 American Transplant Congress
Abstract number: 73
Background
Potential living kidney donors with prediabetes are often excluded due to concerns about the development of diabetes and progression to ESRD. This strategy may be unnecessarily restrictive.
Methods
We conducted a single center retrospective study of living kidney donors from 1996-2007 with serum glucose >100 mg/dl (impaired fasting glucose or IFG). Donors with normal fasting glucose (NFG) matched for age, sex and year of donation were identified as controls. A medical history questionnaire was administered and blood and urine specimens obtained from donors who were successfully contacted and agreed to participate. Continuous variables were analyzed using the t-test and categorical variables were analyzed using Chi-square or Fisher's exact test.
Results
45 prediabetic donors and 45 normal controls were enrolled. Pre-donation characteristics are listed in table 1.
| IFG Donors, n=45 | NFG Donors, n=45 | p value | |
| Male (%) | 19 (42.2) | 20 (44.4) | ns |
| Age, yrs (SD) | 47.1 (11.5) | 47.5 (10.4) | ns |
| Race (%) | ns | ||
| – Caucasian | 29 (64.4) | 26 (57.8) | |
| – African American | 2 (4.4) | 2 (4.4) | |
| – Other | 14 (31.1) | 17 (37.8) | |
| Family history of type 2 diabetes (%) | 11 (24.4) | 10 (22.2) | ns |
| BMI, kg/sq m (SD) | 28.1 (3.9) | 25.3 (4.5) | 0.0022 |
| Mean fasting plasma glucose, mg/dl (SD) | 108.9 (9.4) | 87.1 (7.1) | 0.0001 |
| BP, mm Hg (SD) | ns | ||
| – Systolic | 129 (13.3) | 123.9 (14.9) | |
| – Diastolic | 74.2 (8.7) | 70.4 (9.9) | |
| MDRD eGFR 30 d post-donation (SD) | 60.8 (10.8) | 59.3 (11) | ns |
At study enrollment, mean time from donation was around 10 years for both groups. Medical history and laboratory data are listed in Table 2.
| IFG Donors, n=45 | NFG Donors, n=45 | p value | |
| Age, yrs (SD) | 57.4 (12.1) | 57.4 (10.9) | ns |
| Mean time from donation, yrs (SD) | 10.4 (3.2) | 10.0 (3.1) | ns |
| BMI, kg/sq m (SD) | 27.9 (4.9) | 25.9 (5.1) | 0.0539 |
| History | |||
| – Diabetes (%) yes | 7 (15.6) | 1 (2.2) | 0.0582 |
| – High blood pressure (%) yes | 15 (34.3) | 10 (22.2) | ns |
| Mean fasting plasma glucose, mg/dl (SD) | 104.7 (33.2) | 90.0 (6.5) | 0.0045 |
| – <100 mg/dl (%) | n=27 (60) | n=43 (95.6) | |
| – 100 to 125 mg/dl (%) | n=15 (33.3) | n=2 (4.4) | |
| – >125mg/dl | n=3 (6.7) | n=0 | |
| MDRD eGFR (SD) | 70.7 (16.1) | 67.3 (16.6) | ns |
| Mean urine albumin/cr, mg/g (SD) | 9.7 (26.6) | 5.9 (11.0) | ns |
| – 30 to 300 mg/g | n=2 | n=2 | |
| – >300 mg/g | n=0 | n=0 | |
| Triglycerides, mg/dl (SD) | 130.6 (81.4) | 111.3 (55.3) | ns |
Conclusions
Only a minority (15.6%) of donors with IFG had developed diabetes at 10 years post-donation. Kidney function
To cite this abstract in AMA style:
Chandran S, Masharani U, Webber A, Wojciechowski D. Renal Outcomes in Prediabetic Living Kidney Donors Are Very Similar to Normoglycemic Donors at 10 Years Post-Donation [abstract]. Am J Transplant. 2013; 13 (suppl 5). https://atcmeetingabstracts.com/abstract/renal-outcomes-in-prediabetic-living-kidney-donors-are-very-similar-to-normoglycemic-donors-at-10-years-post-donation/. Accessed May 28, 2020.« Back to 2013 American Transplant Congress