ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Advanced Search

Renal Efficiency: A New Metric for Evaluating Kidneys in Living Donors.

A. Diez, K. Rima, J. Von Visger, U. Nori, T. Pesavento, A. Rajab, M. Henry, R. Pelletier.

The Ohio State University, Columbus, OH.

Meeting: 2016 American Transplant Congress

Abstract number: C148

Keywords: Kidney transplantation, Nephron mass, Renal function

Session Information

Date: Monday, June 13, 2016

Session Name: Poster Session C: Kidney Donor Evaluation and Donor Nephrectomy

Session Time: 6:00pm-7:00pm

 Presentation Time: 6:00pm-7:00pm

Location: Halls C&D

Related Abstracts
  • Improving the Efficiency, Safety and Cost of Evaluating Living Donor Liver Candidates Using Single Sequence MRI.
  • Parameters of Machine Perfusion Evaluating Quality of Kidneys from DCD/ECD Donors

Donor age, quality of the graft, and the size/weight of the donated kidney are factors that may affect subsequent transplant outcomes. Morphological renal measurements may be reliably obtained using 3D reconstructions of CT angiograms (CT-V) yet no metric exists to objectively describe the quality of the donated tissue. We propose creating a new term: “Renal Efficiency” (RE) to fill this void. This term will be defined as the creatinine clearance that is produced per cubic cm (cc) of donated kidney tissue.

Under IRB approval, we retrospectively reviewed data from living kidney donors who donated over 5 years at our center and abstracted demographic and clinical data, pre-donation 24hr timed creatinine clearance measurements (mCrCl) [validated for adequacy of collections] and CT-V. RE was generated by dividing mCrCl (ml/min) by kidney volume (cc). A natural log transformation was employed to reduce variance in data analysis. Natural log transformed renal efficiency was linearly regressed on patient demographics and clinical characteristics. Regression coefficients were back transformed to the original renal efficiency units of ml/min (mCrCl) per cc of renal tissue (CT-V).

312 cases were reviewed. The average total CT-V (combined right and left kidneys) was 349.91 ml (sd 65.96). The average mCrCl was 123.21 ml/min (sd 27.34). We previously described the strong correlation that exists between (mCrCl) and (CT-V) (Pearson Correlation: 0.65, p<0.001).The average RE was 0.35 ml/min (clearance) per cc (renal tissue) [Std Error: 0.003, 95% CI: 0.343 – 0.357]. Both univariable (unadjusted) and multivariable (adjusted) linear regression modeling showed significant correlations with patient age and race. For every ten year increase in age we noted a renal efficiency decreases of 4% (ratio = 0.96, 95% CI: 0.95 – 0.98, p < 0.001). For race renal efficiency increases 10% (ratio = 1.10, 95% CI: 1.04 – 1.16, p = 0.001) in non-whites as compared to whites. This is interesting as some groups (e.g. African Americans) have higher rates of CKD; and may either reflect an associated mechanism, or bias in the patients selected for donation.

Our data show that there is variability in the quality of donated renal tissue. We believe that the term “Renal Efficiency” objectively describes this variability. In further studies we hope to show that combined measurements of renal efficiency and renal volume may predict renal function in kidney transplant recipients.

CITATION INFORMATION: Diez A, Rima K, Von Visger J, Nori U, Pesavento T, Rajab A, Henry M, Pelletier R. Renal Efficiency: A New Metric for Evaluating Kidneys in Living Donors. Am J Transplant. 2016;16 (suppl 3).

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Diez A, Rima K, Visger JVon, Nori U, Pesavento T, Rajab A, Henry M, Pelletier R. Renal Efficiency: A New Metric for Evaluating Kidneys in Living Donors. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/renal-efficiency-a-new-metric-for-evaluating-kidneys-in-living-donors/. Accessed March 1, 2021.

« Back to 2016 American Transplant Congress

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Live Related Kidney Transplant Experience in Abuja, Nigeria – First Eight Cases Ever.
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Live Related Kidney Transplant Experience in Abuja, Nigeria – First Eight Cases Ever.
  • Left-Sided Donor Nephrectomy Predisposes Living Kidney Donors to Latent Adrenal Insufficiency with Symptoms of Fatigue and Inferior Quality of Life.
  • Home
  • Search
  • Penis Transplantation: First U.S. Experience.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2021 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy

loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.