Regeneration of Kidney with a Novel Biomimetic Vascular Scaffold
1Seoul National University Hospital, Seoul 110-744, Korea, Republic of, 2Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC
Meeting: 2019 American Transplant Congress
Abstract number: C94
Keywords: Bioengineering, Kidney
Session Information
Session Name: Poster Session C: Tissue Engineering & Technology
Session Type: Poster Session
Date: Monday, June 3, 2019
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall C & D
*Purpose: Appropriate vascularization is one of the most important issues to be addressed in the clinical application of 3D bioengineered organ.
*Methods: We have fabricated biomimetic collagen vascular scaffold using vascular corrosion casting technique, which offers identical 3D geometry of complex renal vasculature. The vascular scaffold was functionalized with VEGF (VEGF vascular scaffold).
*Results: The VEGF vascular scaffold recruited significantly more endothelial cells compared to the plain vascular scaffold in 2D and 3D in vitro study. The VEGF vascular scaffold was endothelialized well and the implants showed enhanced vascularization which reduced apoptosis of implanted human renal cells when implanted in the renal cortex of nude rats. Hybrid tubule-like structures were formed with implanted human renal cells and migrated host renal cells in VEGF vascular scaffold.
*Conclusions: This work highlights a critical role for early vascularization with the VEGF vascular scaffold in reducing apoptosis of implanted cells as well as formation of renal tissues.
To cite this abstract in AMA style:
Min S, Mo H, Han A, Ha J, Yoo J. Regeneration of Kidney with a Novel Biomimetic Vascular Scaffold [abstract]. Am J Transplant. 2019; 19 (suppl 3). https://atcmeetingabstracts.com/abstract/regeneration-of-kidney-with-a-novel-biomimetic-vascular-scaffold/. Accessed May 12, 2025.« Back to 2019 American Transplant Congress