Psychosocial Factors Associated with Medication Adherence Based on Self Reports in Kidney Allograft Recipients: Baseline Findings from the PRIMA (ImPRoving Adherence to Immunosuppressive Therapy by Mobile Internet Application) Study.
1Department of Surgery, Seoul National University College of Medicine, Seoul, Republic of Korea
2Department of Surgery, Myongji Hospital, Goyang-si, Gyeonggi-do, Republic of Korea
3Korean Organ Donation Agency, Seoul, Republic of Korea.
Meeting: 2016 American Transplant Congress
Abstract number: D279
Keywords: Kidney transplantation, Psychosocial
Session Information
Session Name: Poster Session D: Psychosocial and Treatment Adherence
Session Type: Poster Session
Date: Tuesday, June 14, 2016
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Halls C&D
Background. We have assessed the prevalence of medication nonadherence after kidney transplantation and investigated its psychosocial correlates, as a part of the PRIMA study, an ongoing prospective study using mobile internet application to improve adherence.
Methods. Renal allograft recipients aged 15-70 years old, who were at least 12 month post-transplant were enrolled in the PRIMA study. Initially, self-reported medication adherence was assessed with 4-item Basel Assessment of Adherence to Immunosuppressive Medications Scale (BAASIS-interview): total score 0–20 (0, adherence; > 1, nonadherence). Participants also completed the Korean version of the Hospital Anxiety and Depression Scale (HADS) and the 10–item Big Five Inventory (BFI-10-K) for the self-evaluation of anxiety / depression, and personality traits. Relationship between self-reported adherence and psychosocial factors as well as demographic factors was evaluated.
Results. Among 137 participants, 73 (53.2%) were classified as nonadherent according to the BAASIS-interview. Smoking, longer time since transplantation (≥ 2 years), transplantation from a deceased donor or living donor other than spouse or 1st degree relative, depression (HAD-D; depression subscale ≥ 6), and anxiety (HAD-A; anxiety subscale ≥ 8) were factors associated with self-reported medication nonadherence in univariate analysis. Longer time since transplantation depression (OR 2.57, 95% CI 1.18-5.60, P=0.018), depression (OR 2.28, 95% CI 1.03-5.01, P=0.043) and transplantation from donors other than spouse or 1st degree relative (OR 4.02, 95% CI 1.71-9.42, P=0.001) were also significantly associated with nonadherence in multivariate analysis.
Conclusion. Duration since TPL, depression, and the recipient's relationship with the donor showed significant association with self-reported nonadherence. Such correlates associated with adherence may be a valuable potential target to be considered in designing future studies aimed to improve medication adherence after kidney transplantation.
CITATION INFORMATION: Han A, Choi C, Kim S.-Y, Cho S, Cho M.-J, Lee C, Ahn S, Min S.-I, Min S.-K, Jung I, Kim S, Park M, Ha J. Psychosocial Factors Associated with Medication Adherence Based on Self Reports in Kidney Allograft Recipients: Baseline Findings from the PRIMA (ImPRoving Adherence to Immunosuppressive Therapy by Mobile Internet Application) Study. Am J Transplant. 2016;16 (suppl 3).
To cite this abstract in AMA style:
Han A, Choi C, Kim S-Y, Cho S, Cho M-J, Lee C, Ahn S, Min S-I, Min S-K, Jung I, Kim S, Park M, Ha J. Psychosocial Factors Associated with Medication Adherence Based on Self Reports in Kidney Allograft Recipients: Baseline Findings from the PRIMA (ImPRoving Adherence to Immunosuppressive Therapy by Mobile Internet Application) Study. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/psychosocial-factors-associated-with-medication-adherence-based-on-self-reports-in-kidney-allograft-recipients-baseline-findings-from-the-prima-improving-adherence-to-immunosuppressive-therapy-by-mo/. Accessed May 11, 2025.« Back to 2016 American Transplant Congress