Date: Sunday, May 3, 2015
Session Name: Poster Session B: Bacterial/Fungal/Other Infections
Session Time: 5:30pm-6:30pm
Presentation Time: 5:30pm-6:30pm
Location: Exhibit Hall E
Background: Urinary tract infection (UTI) is the most frequent infection during post-transplant (pTR) follow-up. Aim: To compare the incidence of UTI during the first 6 months pTR with prophylaxis with FT vs. TMP-SMX. Methodology: This is a controlled, randomized, double-blind clinical trial comparing prophylaxis with FT at a dose of 3gr q/10 d + TMP-SMX 875/125 (3 x week) vs. TMP-SMX 875/125 q/24hrs. Transplanted patients over the age of 18 were included. The primary outcome was the time period to the first UTI episode. UTI was defined as a mid-stream urine culture with >100 thousand colony-forming units (CFU) and wo/symptoms or over 1000 CFU w/symptoms. Results: Between 05/2013 and 06/2014, 63 patients were included. Average age was 35.2 yrs (min-max 18 to 72) and 63.4% were male. They were randomized with 32 patients in the FT group and 31 patients in the TMP-SMX group. Median follow-up was 4.9 months (IIC 2.5 to 6.0). There were no significant differences between groups in terms of their general characteristics and UTI risk factors. During follow-up, 23 patients developed at least one UTI episode, with an overall incidence of 36.51%. When comparing the primary outcome, there was no difference between groups (HR1.05 95%CI 0.46 to 2.38 p=0.906). No difference was detected in subgroup analysis. Adverse effects were also not different between groups.
|Outcome||FT (n=32)||TMP-SMX (n=31)||p value|
|UTI+ AB||20 (62.5%)||11(35.48%)||0.032|
|UTI rec + Pyelo||4(12.9%)||8(25.8%)||0.335|
|UTI symptomatic||6 (18.75%)||5 (16.13%)||1.00|
|Hosp. due to UTI||2 (6.2%)||2 (6.2%)||1.0|
To cite this abstract in AMA style:Arreola-Guerra J, Morales-Buenrostro L, Arvizu-Hernandez M, Mancilla-Urrea E, Maria P, Vilatoba-Chapa M, Alberu J, Sifuentes-Osornio J. Prophylaxis of Post-Renal Transplant Urinary Tract Infection With Fosfomycin Trometamol. A Controlled, Randomized Clinical Trial. (Intermediate Analysis) [abstract]. Am J Transplant. 2015; 15 (suppl 3). https://atcmeetingabstracts.com/abstract/prophylaxis-of-post-renal-transplant-urinary-tract-infection-with-fosfomycin-trometamol-a-controlled-randomized-clinical-trial-intermediate-analysis/. Accessed April 20, 2021.
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