Prehypertension and Abnormal Fasting Glucose Are the Main Factors Associated With Progressive Deterioration of Renal Function in Kidney Donors
1Transplantation, National Institute of Nutrition and Medical Sciences Salvador Zubirán, Mexico City, Mexico
2Nephrology and Mineral Metabolism, National Institute of Nutrition and Medical Sciences Salvador Zubirán, Mexico City, Mexico.
Meeting: 2015 American Transplant Congress
Abstract number: B164
Keywords: Donation, Risk factors
Session Information
Session Name: Poster Session B: Living Donor Issues 1
Session Type: Poster Session
Date: Sunday, May 3, 2015
Session Time: 5:30pm-6:30pm
Presentation Time: 5:30pm-6:30pm
Location: Exhibit Hall E
Background: For reasons unclarified, some kidney donors (KD) are patients (pts) that throughout its evolution remain with the same renal function (RF) or even continue to rise, while another group of pts has annual impairment. This study will look for factors associated with progressive deterioration of RF in donors. Methods: This is a cohort study of KD. RF was assessed by the estimation formula CKD-EPI (eGFR) at 3 to 6 months postnephrectomy and at the end of follow-up. They classified pts as positive or negative slope according to the trend of eGFR over time of evolution (eGFR 3 to 6 mo postnephrectomy – eGFR last follow-up) ÷ (years of follow-up). Results: We included 162 pts with mean age to donation of 36.5y (± 11.9), slight predominance of females (56.1%). The average follow-up time was 12.5y (± 6.7). Pts classified as negative slope had an average annual loss of: -1.7 ml/min (min-max -0.5 to -7.0), while positive slope group had +0.83 ml/min (min-max -0.47 to +10.04). Upon completion of the follow-up, 13 of the 41 pts classified as negative slope group, had a eGFR below 60 ml/min, (31.7% vs 19.1%, p= 0.09) and 5 of them below 45 ml/min (12.2% vs 25.1% p= 0.012). Factors associated with negative slope are presented in Table 1.
Variables | Univariate OR(CI95%) | p value | Multivariate 1 OR(CI95%) | p value | Multivariate 2 OR (CI95%) | p value |
Age | 1.05(0.9 – 1.03) | 0.74 | 1.04 (1.008 – 1.08) | 0.017 | 1.001 (0.9 – 1.03) | 0.92 |
Male | 2.2 (1.1 – 4.6) | 0.02 | 2.5 (1.1 – 5.9) | 0.024 | 2.2 (1.04 – 4.6) | 0.038 |
Pre-HAS | 3.1 (1.3 – 7.5) | 0.01 | 2.8 (1.04 – 7.6) | 0.04 | 2.5 (1.02 – 6.5) | 0.04 |
AFG | 2.03 (1.1 – 6.3) | 0.02 | 2.4 (1.001 – 6.1) | 0.05 | ||
Obesity | 2.7 (0.8 – 8.7) | 0.08 | ||||
eGFR 3Mo | 1.05 (1.02 – 1.07) | <0.01 | 1.07 (1.03 – 1.1) | <0.01 |
To cite this abstract in AMA style:
Arreola-Guerra J, Arvizu-Hernandez M, Correa-Rotter R, Morales-Buenrostro L, Alberu J. Prehypertension and Abnormal Fasting Glucose Are the Main Factors Associated With Progressive Deterioration of Renal Function in Kidney Donors [abstract]. Am J Transplant. 2015; 15 (suppl 3). https://atcmeetingabstracts.com/abstract/prehypertension-and-abnormal-fasting-glucose-are-the-main-factors-associated-with-progressive-deterioration-of-renal-function-in-kidney-donors/. Accessed December 13, 2024.« Back to 2015 American Transplant Congress