Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall 4EF
Lupus nephritis (LN) predominately affects females of childbearing age. This study aims to characterize pregnancy outcomes in kidney transplant recipients (KT) with LN compared to other glomerulonephritis (other-GN) and non-glomerular diseases (non-GN). We analyzed 1022 KT with 1867 pregnancies and 1932 outcomes reported to Transplant Pregnancy Registry International.
|Pregnancy outcomes in kidney transplant recipients|
|Age at conception, yrs||30±5||30±5||30±5||NS|
|DM during pregnancy||2%||3%||12%*||<0.01|
|Creatinine before pregnancy, mg/dl||1.33±0.47||1.25±0.39||1.24±0.42||NS|
|Creatinine during pregnancy, mg/dl||1.40±0.57||1.29±0.57||1.35±0.81||NS|
|Creatinine postpartum, mg/dl||1.52±0.7||1.38±0.75||1.41±0.76||NS|
|Biopsy proven acute rejection during pregnancy||1%||1%||1%||NS|
|Graft loss within 2 yrs of pregnancy||9%||6%||5%||NS|
|Gestational age, wks||36±3||36±3||36±3||NS|
|Premature (<37wk of gestation)||53%||49%||52%||NS|
|Birth weight, g||2547±769||2637±772$||2511±746||0.01|
|#ANOVA or chi2; mean±SD for all continuous variables; NS non-significant;*non-GN statistically different from LN and other-GN;$other-GN statistically different from non-GN|
Conclusions: The majority of pregnancies in KT with LN resulted in live births with high rate of preeclampsia and prematurity. Overall, post-transplant pregnancies in LN are successful and the outcomes are similar to KT with other ESRD etiologies.
CITATION INFORMATION: Rao S., Coscia L., Armenti D., Moritz M., Constantinescu S. Pregnancy Outcomes in Kidney Recipients with Lupus Nephritis Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:Rao S, Coscia L, Armenti D, Moritz M, Constantinescu S. Pregnancy Outcomes in Kidney Recipients with Lupus Nephritis [abstract]. https://atcmeetingabstracts.com/abstract/pregnancy-outcomes-in-kidney-recipients-with-lupus-nephritis/. Accessed July 3, 2020.
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