Pregnancy Outcomes in Kidney Recipients with Lupus Nephritis
1Transplant Pregnancy Registry International, Gift of Life Institute, Philadelphia, PA
2Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA
3Surgery, Lehigh Valley Health Network, Allentown, PA
4Surgery, Morsani College of Medicine, Tampa, FL.
Meeting: 2018 American Transplant Congress
Abstract number: B205
Keywords: Kidney transplantation, Pregnancy, Quality of life
Session Information
Session Name: Poster Session B: Kidney Psychosocial
Session Type: Poster Session
Date: Sunday, June 3, 2018
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall 4EF
Lupus nephritis (LN) predominately affects females of childbearing age. This study aims to characterize pregnancy outcomes in kidney transplant recipients (KT) with LN compared to other glomerulonephritis (other-GN) and non-glomerular diseases (non-GN). We analyzed 1022 KT with 1867 pregnancies and 1932 outcomes reported to Transplant Pregnancy Registry International.
| Pregnancy outcomes in kidney transplant recipients | ||||
| LN | other-GN | non-GN | p-value# | |
| Recipients/Pregnancies/Outcomes | 95/155/158 | 439/851/884 | 488/861/890 | |
| MATERNAL FACTORS | ||||
| Age at conception, yrs | 30±5 | 30±5 | 30±5 | NS |
| Preeclampsia | 27% | 30% | 31% | NS |
| DM during pregnancy | 2% | 3% | 12%* | <0.01 |
| Creatinine before pregnancy, mg/dl | 1.33±0.47 | 1.25±0.39 | 1.24±0.42 | NS |
| Creatinine during pregnancy, mg/dl | 1.40±0.57 | 1.29±0.57 | 1.35±0.81 | NS |
| Creatinine postpartum, mg/dl | 1.52±0.7 | 1.38±0.75 | 1.41±0.76 | NS |
| Biopsy proven acute rejection during pregnancy | 1% | 1% | 1% | NS |
| Graft loss within 2 yrs of pregnancy | 9% | 6% | 5% | NS |
| PREGNANCY OUTCOMES | ||||
| Miscarriages | 18% | 17.1% | 19% | NS |
| Live births,% | 75% | 76.4% | 73% | NS |
| Gestational age, wks | 36±3 | 36±3 | 36±3 | NS |
| Premature (<37wk of gestation) | 53% | 49% | 52% | NS |
| Birth weight, g | 2547±769 | 2637±772$ | 2511±746 | 0.01 |
| Birth defects | 8% | 3.4% | 4.5% | NS |
| Cesarean section | 47% | 51%$ | 57% | 0.04 |
| #ANOVA or chi2; mean±SD for all continuous variables; NS non-significant;*non-GN statistically different from LN and other-GN;$other-GN statistically different from non-GN | ||||
Conclusions: The majority of pregnancies in KT with LN resulted in live births with high rate of preeclampsia and prematurity. Overall, post-transplant pregnancies in LN are successful and the outcomes are similar to KT with other ESRD etiologies.
CITATION INFORMATION: Rao S., Coscia L., Armenti D., Moritz M., Constantinescu S. Pregnancy Outcomes in Kidney Recipients with Lupus Nephritis Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:
Rao S, Coscia L, Armenti D, Moritz M, Constantinescu S. Pregnancy Outcomes in Kidney Recipients with Lupus Nephritis [abstract]. https://atcmeetingabstracts.com/abstract/pregnancy-outcomes-in-kidney-recipients-with-lupus-nephritis/. Accessed December 3, 2024.« Back to 2018 American Transplant Congress