*Purpose: Uterus transplantation (UTx) is a repeatedly proven treatment for women with absolute uterine factor infertility who wish to carry a pregnancy. One aspect of UTx is the potential for transmission of cytomegalovirus (CMV) from the donor to the recipient. CMV infection is not only a frequent complication after solid organ transplantation but also poses a risk to the fetus during pregnancy after UTx. To date, there have been no reported cases of pregnancy following UTx from CMV positive donors into CMV negative recipients.

*Methods: Chart review of a case in which a CMV negative UTx recipient received a CMV positive living donor uterine graft and developed active CMV infection prior to embryo transfer.

*Results: The UTx recipient was treated with 3 months of prophylactic Valcyte after transplantation and was monitored with CMV serum PCR every week. She developed an asymptomatic CMV infection 5 months post-transplant and was successfully treated with ganciclovir and cleared the virus. Single embryo transfer was performed 8 months post UTx. She did not have recurrence of CMV during pregnancy. She delivered a healthy baby at 37 weeks gestation.

*Conclusions: This case shows that CMV positive donors may be used for CMV negative recipients in UTx. However, these patients should be closely monitored for CMV infection during the post-transplant course and subsequent pregnancy.

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