Session Time: 3:15pm-4:00pm
Presentation Time: 3:30pm-4:00pm
*Purpose: Among pediatric kidney donors the discard rate is highest among donors under 3-years-old. This study aims to identify factors predicting discard and construct a discard risk index (pkDSRI).
*Methods: The United Network of Organ Sharing (UNOS) database was used to retrospectively analyze 3,972 deceased donors (<=3-years-old) through univariate and multivariate logistic regressions. Donors were divided into a training set (n = 2,648 donors, 66.67%) and a validation set (n = 1,324 donors, 33.33%). The training set was used to derive an index for kidney discard. Factors significant in the univariate analysis (p< 0.05) and multivariate analysis were incorporated into a pkDSRI score. The pkDSRI was internally validated with the validation set.
*Results: Eighty-nine potential risk factors for kidney discard were examined and identified, and 34 were significant predictors (p <0.05). The most significant factor was: Age<1 (odds ratio [OR], 6.39; confidence interval [CI], 3.33-12.25). Equation 1 presents the risk equation used to calculate the DSRI. The DSRI has a C-statistic of 0.79 for the training set and 0.77 for the validation set.
*Conclusions: The pkDSRI uses 5 significant risk factors, including elevated lab values (creatinine) donor age, and region (UNOS regions 5, 10), to accurately predict risk of kidney discard with a C-stat of 0.79 in a population experiencing a high discard rate (28.93%). The pkDSRI can be used to predict discard and identify high probability discard donors for aggressive allocation.
To cite this abstract in AMA style:Joshi M, Price M, Rana A. Predicting Kidney Discard among Donors Age 0-3: A Discard Risk Index [abstract]. Am J Transplant. 2020; 20 (suppl 3). https://atcmeetingabstracts.com/abstract/predicting-kidney-discard-among-donors-age-0-3-a-discard-risk-index/. Accessed November 25, 2020.
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