Pancreas Outcomes between Living and Deceased Kidney Donor Recipients in Pancreas after Kidney Transplantation
1Nephrology and Kidney Transplantation Department, Hospital Clinic, Barcelona, Spain
2Hepatobiliopancreatic and Liver Transplant Department, Hospital Clinic, Barcelona, Spain
3Organ Transplantation Coordination Department, Hospital Clinic, Barcelona, Spain
4Laboratori Experimental de Nefrologia I Trasplantament (LENIT), IDIBAPS, Barcelona, Spain
5Diabetes Unit, Department of Endocrinology and Nutrition, Hospital Clinic, Barcelona, Spain.
Meeting: 2018 American Transplant Congress
Abstract number: A344
Keywords: Pancreas transplantation
Session Information
Session Name: Poster Session A: Pancreas and Islet: All Topics
Session Type: Poster Session
Date: Saturday, June 2, 2018
Session Time: 5:30pm-7:30pm
Presentation Time: 5:30pm-7:30pm
Location: Hall 4EF
Pancreas outcomes in pancreas after kidney transplantation have been reported as being inferior to those from simultaneous pancreas-pancreas (SPK). The influence of kidney donor (living- vs deceased-donor) has never been previously addressed. We retrospectively analyzed all pancreas transplants performed in a single center since 2007, and compared the outcomes from those who had previously received a living-donor kidney transplant (PAldK; n=18) or a deceased-donor kidney transplant (PAddK; n=28), using SPK (n=139) recipients as reference. Pancreas survival was similar between all groups, but inferior for PAldK when included only those with functioning graft at day 90 post-transplant (p=.004). Pancreas acute rejection was significantly increased in PAldK (67%; 1,8±1,4 episodes/graft) when compared to PAddK (25%) and SPK (32%) (p<.05; figure1). In a multivariate Cox regression model including known risk factors for pancreas rejection, PAldK was the only predictor of acute rejection (HR 6,82 95% CI 1,51-30,70, p<.05). No association was found between donor-recipient HLA mismatches and graft rejection. Repeated HLA incompatibilities between kidney and pancreas donors (0 vs 1-6) did not correlate with pancreas graft rejection or survival in both PAK groups (p>.05). In conclusion, pancreas graft outcomes are worse for PAldK when compared to PAddK and SPK.
CITATION INFORMATION: Ventura-Aguiar P., Ferrer J., Revuelta I., Paredes D., De-Sousa E., Rovira J., Esmatjes E., Garcia-Valdecasas J., Oppenheimer F., Diekmann F., Ricart M. Pancreas Outcomes between Living and Deceased Kidney Donor Recipients in Pancreas after Kidney Transplantation Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:
Ventura-Aguiar P, Ferrer J, Revuelta I, Paredes D, De-Sousa E, Rovira J, Esmatjes E, Garcia-Valdecasas J, Oppenheimer F, Diekmann F, Ricart M. Pancreas Outcomes between Living and Deceased Kidney Donor Recipients in Pancreas after Kidney Transplantation [abstract]. https://atcmeetingabstracts.com/abstract/pancreas-outcomes-between-living-and-deceased-kidney-donor-recipients-in-pancreas-after-kidney-transplantation/. Accessed October 15, 2024.« Back to 2018 American Transplant Congress