Background: Diabetic CKD patients present increased morbidity and mortality due to cardiovascular complications. Pancreas transplantation can restore insulin independence in patients with type I diabetes and simultaneous pancreas and kidney transplantation is now the gold standard treatment for them. However, the number of PT in patients with type II diabetes has steadily increased.

Methods: From June 1992 to December 2012, we performed 350 pancreas transplantation. Among them, 64 recipients were type II diabetes (18.3%). We analyzed their characteristics and graft outcomes.

Results: Among 64 recipients with type II diabetes, SPK were 27 (42%), PAK were 22 (35%), SPLK were 9(14%), and PTA was 6(9%). Pancreas graft survival of recipients with type II diabetes is 92.1%, 84.4%, and 75.0% at 1, 5, and 10 years post-transplant, respectively. The graft and patient survival between type I and II was not significantly different (p=0.344) and type II didn't increase the risk of graft failure and patient mortality (HR 0.825, 95% CI 0.372-1.414, p=0.346, and HR 1.099, 95% CI 0.369-3.272, p=0.865). In subgroup analyses, SPK, PAK, and SPLK reached 92.6%, 84.6%, and 81.2% respectively at 5 year after transplantation. SPK also doesn't pose an additional risk to the graft kidney itself.

Conclusion: For type II diabetic patients with CKD, pancreas transplantation and especially SPK can be a considerable treatment option to restore normoglycemia and freedom from insulin and dialysis by the improvement of allograft and patient survival.

CITATION INFORMATION: Choi J., Jung J., Kwon H., Shin S., Kim Y., Han D. Pancreas and Kidney Co-Transplantation in Type II Diabetes: A Single Center Experience Am J Transplant. 2017;17 (suppl 3).

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