Abstracts Archive - Page 766 of 1683 - ATC Abstracts

2018 American Transplant Congress
Immune Modulatory Effect of Thalidomide and Dexamethasone Co-Treatment on Murine Splenocytes
E. Kim,^1,2 J. Kim,¹ K. Huh,^1,3 Y. Cho,¹ M. Kim,^1,3 Y. Kim,^1,3 B. Kim.^1,4
¹The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea; ²Brain Korea 21 PLUS Project for Medical Science, Yonsei University, Seoul, Korea; ³Department of Transplantation Surgery, Yonsei University College of Medicine, Seoul, Korea; ⁴Department of Internal Medicine, Nephrology, Yonsei University College of Medicine, Seoul, Korea.
Thalidomide (TM) is known to have anti-inflammatory effects and dexamethasone (DX) is also well known to reduce inflammation and inhibit inflammatory cytokine production. Clinically, combinatorial…
2018 American Transplant Congress
The Superiority of Plasma Enriched Perfusate for Assessment of Donor Kidneys in an Ex-Vivo Normothermic Perfusion (EVNP) Setting
J. Palma, I. Palma, Y. Smolin, A. Perry, J. Sageshima, R. Perez.
Surgery, Transplant Division, UC Davis Health System, Sacramento, CA.
EVNP has been used to assess and repair marginal organs prior to transplantation but the optimal perfusate composition is unknown. We hypothesize that EVNP with…
2018 American Transplant Congress
Biliary pH, Bicarbonate and Glucose Are Suitable Biomarkers of Bile Duct Viability during Normothermic Machine Perfusion of Human Donor Livers
A. Matton,^1,2 Y. de Vries,^1,2 L. Burlage,^1,2 R. van Rijn,^1,2 A. Gouw,³ V. de Meijer,¹ T. Lisman,² R. Porte.¹
¹Department of Surgery, Section Hepatopancreatobiliary Surgery & Liver Transplantation, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; ²Surgical Research Laboratory, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; ³Department of Pathology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Background: Normothermic machine perfusion (NMP) is rapidly making its way into the clinic and can be used for viability assessment of human donor livers prior…
2018 American Transplant Congress
Graft CEACAM1 is Essential to Autophagy Induction and T-Cell Regulation in Liver Transplantation: From Mouse-to-Human
K. Nakamura,¹ S. Kageyama,¹ M. Kujawski,² T. Ito,¹ A. Aziz,¹ D. Oncel,¹ B. Ke,¹ R. Sossa,³ E. Reed,³ F. Kaldas,¹ R. Busuttil,¹ J. Kupiec-Weglinski.¹
¹Surgery, Liver Transplant, UCLA, Los Angeles, CA; ²Molecular Immunology, City of Hope, Duarte, CA; ³Pathology, UCLA, Los Angeles, CA.
We have documented crucial role of TIM-3 dependent T cell dysfunction in mouse orthotopic liver transplantation (OLT). CEACAM1 (CM1; Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1),…
2018 American Transplant Congress
Differences in Preservation Solution Formulas and Its Effects on Early Graft Function
J. Brooks, P. Wiederhold, K. Jiles, A. Chiodo Ortiz, M. Dewey, M. Bailey, N. Koizumi, E. Rady, J. Ortiz.
University of Toledo Medical Center, Toledo, OH; University of California-Los Angeles, Los Angeles, CA; Life Connection of Ohio, Maumee, OH; George Mason University, Fairfax, VA.
Introduction: Machine perfusion has proven benefits and is common practice among transplant centers. However, the formulas of preservation solutions vary between organ procurement organizations (OPOs).…
2018 American Transplant Congress
Ischemia-Free Liver Transplantation in Pigs: Ischemia Reperfusion Injury is Avoidable?
Z. Guo, X. He, Y. Tang, F. Ji, Z. Zhang, Q. Zhao, S. Huang, Z. Zhu, W. Ju, G. Chen.
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
BACKGROUND&AIMS: In organ transplantation, ischemia and reperfusion injury (IRI) is considered as an inevitable event and the major contributor of graft failure. Great efforts have…
2018 American Transplant Congress
The Role of Ex Vivo Normothermic Preservation in Minimizing Postreperfusion Syndrome in Liver Transplantation
A. Hassan, J. Cywinski, Q. Liu, D. Pezzati, D. Yang, L. Liu, G. Iuppa, K. Hashimoto, F. Aucejo, M. Fujiki, B. Eghtesad, S. Irefin, J. Fung, K. Abu-Elmagd, C. Miller, C. Quintini.
Transplant Surgery, Cleveland Clinic, Cleveland.
Background:Graft reperfusion holds a major challenge during liver transplantation. NMP may improve post-reperfusion hemodynamics, reduce vasopressor and blood product transfusion.Methods:15 patients with liver transplantation after…
2018 American Transplant Congress
Ex-Situ Normothermic Human Upper Extremity Perfusion: Preliminary Report
V. Fahradyan, E. Dalla Pozza, M. Madajka, K. Cho, N. Dawlagala, E. Duraes, H. Shah, S. Al-deen Said, C. Ordenana, F. Papay, A. Rampazzo, B. Bassiri Gharb.
Plastic Surgery, Cleveland Clinic, Cleveland, OH.
Purpose: Ischemia time remains a significant limiting factor for successful extremity replantation and transplantation. Normothermic ex-situ perfusion is a novel method of a limb preservation…
2018 American Transplant Congress
Evaluation of a Marine OXYgen Carrier (Hemo2Life®) for Organ Preservation: First Use in Kidney Transplantation in Humans
Y. Le Meur,¹ E. Morellon,² M. Essig,³ A. Thierry,⁴ M. Buchler,⁵ S. Drouin,⁶ C. Deruelle,¹ L. Badet,² F. Pesteil,³ P-.O. Delpech,⁴ J-.M. Boutin,⁵ B. Barrou.⁶
¹Transplantation, University Hospital, Brest, France; ²Hopital Edouard Herriot, Lyon, France; ³University Hospital, Limoges, France; ⁴University Hospital, Poitiers, France; ⁵University Hospital, Tours, France; ⁶La Pitié Salpetrière, Paris, France.
Preventing ischemia/reperfusion injuries (IRIs) is a major issue in organ transplantation. At present, grafts are preserved at 4[deg]C in preservation solution in order to reduce…
2018 American Transplant Congress
Allogeneic Mesenchymal Stem Cells as Induction Therapy Are Safe and Feasible in Renal Allografts: Pilot Results of a Multicenter Randomized Controlled Trial
Q. Sun,¹ F. Han,¹ M. Zhao,² R. Cao,³ D. Zhao,¹ Z. Huang,¹ L. Hong,¹ Y. Peng,¹ Q. Sun.¹
¹Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; ²Zhujiang Hospital, Southern Medical University, Guangzhou, China; ³Second Affiliated Hospital, Guangzhou Traditional Chinese Medicine University, Guangzhou, China.
Background: Delayed graft function (DGF) and acute rejection lead to adverse effects on graft outcomes. Optimal induction intervention should include both renal structure injury repair…