2022 American Transplant Congress
HDAC Inhibitors Suppress Endothelial Inflammation but Alter Identity
Pathology and Laboratory Medicine, UCLA, Los Angeles, CA
*Purpose: Histone modifications such as acetylation control gene expression. Histone deacetylases (HDACs) have been proposed as an attractive therapeutic approach to counteract detrimental gene expression,…2022 American Transplant Congress
Antibody Response to Sars- Cov -2 Mrna Vaccine in Kidney Transplant Recipients
Nephrology, Hamad Medical Corporation, Doha, Qatar
*Purpose: Kidney transplant recipients are vulnerable to develop severe form of COVID19 Infection. Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccine has significantly…2022 American Transplant Congress
Detection of Microbiota from Catheter Tip in Hemodialysis Patients During the Perioperative Period of Kidney Transplantation Based on Metagenomics: A Prospective Study
Department of Transplantation, Nanfang Hospital, Southern Medical University, Guangzhou, China
*Purpose: Catheter-related infection (CRI) is the most serious complication in dialysis patients. However, current studies are limited to routine culture or immunological examination of CRI.…2022 American Transplant Congress
Pathological Changes in Kidney Allografts Associated with COVID-19 Vaccination
Christiana Care Health System - Kidney Transplant Program, Newark, DE
*Purpose: The Coronavirus Disease 2019 (COVID-19) pandemic prompted widespread vaccination for the immunosuppressed population starting in January 2021 with minimal information on safety outcomes. The…2022 American Transplant Congress
Solid Organ Pancreas Transplantation Offers Superior Glycemic Control Compared to State of the Art Insulin Delivery with Continuous Glucose Monitoring (CGM)
Columbia University, New York, NY
*Purpose: Advanced insulin delivery systems with CGM fail to keep serum glucose within range (70-180 mmol/L) 30-40% of the time resulting in Hgb A1C goals…2022 American Transplant Congress
Allograft TLR9 is Required for Endogenous Donor-Reactive Memory CD8 T Cell Activation in High-Risk Cardiac Allografts to Mediate CTLA-4Ig Resistant Graft Rejection
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Prolonged allograft cold ischemic storage (CIS) and subsequent increased ischemia-reperfusion injury (IRI) following solid organ transplant act through innate immune pathways that promote early…2022 American Transplant Congress
Infection Impacts dd-cfDNA in Lung Transplant Recipients
*Purpose: Infection is the leading cause of death within 1 year post lung transplant. Graft injury secondary to infection is affected by both source and…2022 American Transplant Congress
Estimating the Effect of Increased Donor Heart Ischemic Time on Post-Transplant Survival Using Instrumental Variables
*Purpose: Isolate the impact of organ ischemic time on post-transplant survival using the recent change in heart allocation policy as a natural experiment.*Methods: We examined…2022 American Transplant Congress
Donor Derived Transmissions 2020: Analysis of the OPTN Ad Hoc Disease Transmission Advisory Committee (DTAC) with a Focus on COVID-19
1OPTN DTAC, Richmond, VA, 2UNOS, Richmond, VA
*Purpose: The OPTN DTAC, a multidisciplinary group, evaluates potential donor derived transmission events (PDDTE) to assess the likelihood of disease transmission.*Methods: Retrospective study of PDDTE…2022 American Transplant Congress
Evaluation of Donor Exclusion Criteria in Living Donor Liver Transplantation: A Single-Center Experience
Hepatobiliary Surgery and Liver Transplantation, Lahey Hospital and Medical Center, Burlington, MA
*Purpose: Liver donation is fundamental in increasing the pool of available grafts. Careful evaluation of each donor ensures the best outcomes for the recipient and…
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