Abstracts Archive - Page 600 of 1683 - ATC Abstracts

2019 American Transplant Congress
Differences in the Cost of Kidney Organ Recovery by Organ Procurement Organization Size
P. J. Held¹, J. Bragg-Gresham², J. P. Roberts³
¹Stanford University, Stanford, CA, ²Univ of Michigan, Michigan, MI, ³Univ of California-San Francisco, San Francisco, CA
*Purpose: Economic theory suggests that there should be an initial decrease in costs of products as production levels increase. Using data from independent OPOs we…
2019 American Transplant Congress
Differences in the Cost of Recovering Organs over Time
J. P. Roberts¹, J. Bragg-Gresham², P. Held³
¹Univ of California-San Francisco, San Francisco, CA, ²Univ of Michigan, Ann Arbor, CA, ³Stanford University, Stanford, CA
*Purpose: To report on the level and changes over time in the OPOs’ cost of recovering deceased donor organs (kidneys; livers; hearts; and lungs).*Methods: Cost…
2019 American Transplant Congress
Costimulatory Blockade and Allo-Specific Treg Therapy for Liver Transplant Recipients: Preclinical Data
L. Contreras-Ruiz¹, K. Shimozawa², R. Zhang¹, L. Turka³, J. F. Markmann³, E. C. Guinan²
¹Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, ²Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA, ³Center of Transplantation Sciences, Massachussetts General Hosp., Boston, MA
*Purpose: Adoptive transfer of ex vivo generated donor-specific regulatory T cells (Treg) by using CD28/B7 costimulatory blockade (CSB) to induce transplant (TX) tolerance and minimize…
2019 American Transplant Congress
Immune Cells Composition of Humanized Mouse Kidney Compared to Normal Human Kidney
S. Noel¹, J. T. Kurzhagen¹, S. Lee¹, M. Sadasivam², A. R. Hamad², P. M. Pierorazio³, H. Rabb¹
¹Medicine, Johns Hopkins University, Baltimore, MD, ²Pathology, Johns Hopkins University, Baltimore, MD, ³Urology, Johns Hopkins University, Baltimore, MD
*Purpose: Most clinical studies fail in spite of promising mouse studies, in part due to fundamental differences between mice and human responses. Attempts have been…
2019 American Transplant Congress
Full and Sustained Donor Hematopoietic Chimerism after an Isolated Kidney Transplantation
J. Zuber¹, O. Boyer¹, B. Neven¹, E. Six², R. Berthaud¹, M. Ould Rabah¹, S. Sobrino², C. Lagresle², I. André-Schmutz², M. Cavazzana¹, S. Blanche¹, R. Salomon¹
¹Paris Descartes University, Paris, France, ²Inserm UMRS 1163, Paris, France
*Purpose: Full donor chimerism was reported three times in the absence of myelosuppressive regimen, only after liver or multivisceral transplantation, but never after kidney transplantation.…
2019 American Transplant Congress
Responder B Cell Depletion Increased Allo-Reactive Regulatory T Cells Generated in Allo-Anergization
N. Tanimine¹, L. Contreras-Ruiz², K. Deng¹, N. Feeney¹, C. Rickert¹, K. Lee¹, E. Guinan³, J. Markmann¹
¹Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, ³Department of Radiation Oncology, Dana Farber Cancer Institute, Boston, MA
*Purpose: Regulatory T cells (Tregs) are promising tool for induction and maintenance of transplantation tolerance. We have done a feasibility trial in kidney transplant recipients…
2019 American Transplant Congress
RNA Splicing and Lineage Progression: Identification of an Integrated Splicing Pattern in Endodermal Lineage Progression
J. Fair¹, N. Liu¹, S. G. Widen², W. S. Fagg¹
¹Surgery, University of Texas Medical Branch, Galveston, TX, ²Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX
*Purpose: Epigenetic states such as histone modifications and DNA methylation that influence transcription are well-characterized regulators of stem cell pluripotency and differentiation to specific lineages.…
2019 American Transplant Congress
Pluripotent Stem Cell Differentiation: Delaying Forward Differentiation Signals Maintains Definitive Endoderm Phenotype for Cellular Transplantation
J. Fair¹, M. M. Shoja¹, N. Liu¹, I. Patrikeev², M. Motamedi², W. S. Fagg¹
¹Surgery, University of Texas Medical Branch, Galveston, TX, ²Opthalmology and Visual Sciences, University of Texas Medical Branch, Galveston, TX
*Purpose: Endodermal precursors (EP), derived in vitro from mouse pluripotent stem cell (PSC) sources, are capable of clinically useful engraftment in the unmodified (quiescent) liver…
2019 American Transplant Congress
Generation of Thymic Epithelial Cells from Induced Pluripotent Stem Cells to Prolong Allograft Survival
R. Otsuka, H. Wada, H. Tsuji, A. Sasaki, T. Murata, M. Baghdadi, K. Seino
Institute for Genetic Medicine, Hokkaido University, Sapporo, Hokkaido, Japan
*Purpose: Pluripotent stem cell (PSC) is a potential source of generating functional therapeutic cells for transplantation. Embryonic stem cells are of absolutely allogeneic origin. Induced…
2019 American Transplant Congress
Analysis and Regulation of Immune Reaction in the Transplantation from MHC Homozygous Donors to Heterozygous Recipients with Minor Antigen Mismatches
T. Murata, H. Wada, R. Otsuka, H. Tsuji, A. Sasaki, M. Baghdadi, K. Seino
Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
*Purpose: Induced pluripotent stem cells (iPSCs) is expected to be the source of therapeutic cells in the regenerative medicine. Autologous derivation of iPSCs is the…