2020 American Transplant Congress
Pre-Transplant Monocyte HDAC6 Expression and Risk of Primary Graft Dysfunction in Clinical Lung Transplant Recipients
*Purpose: Lung transplantation (Tx) in ~30% of cases is subject to primary graft dysfunction (PGD), the severe acute lung injury that occurs within 72 hours…2020 American Transplant Congress
Transient Cd4+ T Cell and Cd20+ B Cell Depletion Leads to Prolonged Pig-To-Primate Kidney Xenograft Survival
1Emory University School of Medicine, Atlanta, GA, 2University of Miami, Miami, FL
*Purpose: “Delayed” antibody-mediated xenograft rejection is the one of the most important obstacle to clinical application of pig organ xenografts. The aim of this study…2020 American Transplant Congress
Exosomes Containing Kidney Self-Antigens (Collagen Iv, Fibronectin, Perlecan) Predicts Progression of Chronic Immune Injury in Kidney Transplant Recipients
*Purpose: We have shown that circulating exosome with lung self-antigens (SAgs) are detectable 1 year prior to chronic lung allograft dysfunction, independent of circulating antibodies.…2020 American Transplant Congress
Development and Characterization of Decellularized Whole Human Livers for Increasing Donor Pool
Massachusetts General Hospital - Harvard Medical School, Boston, MA
*Purpose: Liver diseases are recognized as the second leading cause of mortality amongst all digestive diseases in the United States. Orthotopic liver transplantation leads to…2020 American Transplant Congress
CD137 Signaling in Regulatory Dendritic Cells Is Required for Suppressing a Systemic Inflammation in the bm12-Inducible Model of Systemic Lupus Erythematosus
*Purpose: Although CD137 is well known as a costimulatory receptor in T cells, limited information is available for its immunoregulatory function. Here, we report that…2020 American Transplant Congress
Prevalence of Frailty and Cognitive Impairment at Time of Kidney Transplant Evaluation
Internal Medicine, Division of Nephrology, University of Kansas Medical Center, Kansas City, KS
*Purpose: Frailty is highly prevalent in kidney disease, with prevalence estimates as high as 73% in patients at the time of dialysis initiation compared to…2020 American Transplant Congress
Anti-Thymocyte Globulins Induced Immunomodulatory Effect and Increased Regulatory T Cell in a In Vitro Model of Allogeneic Cell Coculture
*Purpose: Two types of Anti-Thymocyte Globulins (ATG) are commonly used in renal transplantation (Thymoglobuline and Grafalon) and induce severe, dose-dependent and sometimes persistent CD4+ T…2020 American Transplant Congress
B Cell Depletion with Anti-CD20 mAb Exacerbates Anti-Donor CD4+ T Cell Responses in Highly Sensitized Transplant Model
Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan
*Purpose: Preformed donor-specific anti-human leukocyte antigen antibodies (DSAs) have been associated with detrimental effects in transplant recipients. To eliminate preformed DSAs, we desensitized DSA-positive recipients…2020 American Transplant Congress
UK Residents Transplanted Overseas: A Summary of UK Data from 2000-2016
*Purpose: Organ shortage has prompted UK residents to source organs overseas. Little is known about the circumstances in which these transplants take place, but stories…2020 American Transplant Congress
Outcomes of Kidney Transplant Recipients with Depression and Anxiety
University of Minnesota, Minneapolis, MN
*Purpose: The outcomes of kidney transplantation in patients with depression and anxiety have been limited by small numbers. This is despite high prevalence of these…
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