Abstracts Archive - Page 448 of 1683 - ATC Abstracts

2020 American Transplant Congress
Stem Cell and Novel Neurotrophic Factors to Promote Functional Outcomes in Limb Transplantation
S. K. Salgar, J. Weiss, C. Phillips, E. Malin, V. Gorantla, J. Harding
Clinical Investigation, Madigan Army Medical Center, Tacoma, WA
*Purpose: Recently, transplantation of hand and face has become a new clinical specialty. The objective of this study was to determine whether adult Mesenchymal Stem…
2020 American Transplant Congress
Normothermic Ex Vivo Perfusion of Marginal Liver Grafts Rapidly Stimulates Release of Graft-Derived Exosomes and Markedly Decreases the Inflammatory Pathways Induced at Early Times after Transplant Reperfusion
K. E. Brown¹, K. S. Keslar¹, D. Margeta¹, Q. Liu², A. Simioni², L. Del Angel Diaz², W. M. Baldwin¹, R. L. Fairchild¹, C. Quintini²
¹Lerner Research Institute, Cleveland Clinic, Cleveland, OH, ²Transplant Center, Cleveland Clinic, Cleveland, OH
*Purpose: Normothermic ex vivo machine perfusion of liver grafts (EVLP) is emerging as a superior preservation technology to cold storage. Normothermic EVLP transforms a metabolically…
2020 American Transplant Congress
Use of Direct Acting Antiviral Medications in Transplant Recipients Receiving Organs from Hepatitis C Viremic Donors
S. Bova¹, A. Cameron¹, C. Durand¹, J. Katzianer², M. LeGrand², L. Boyer¹, J. Glorioso³, L. P. Toman¹
¹The Johns Hopkins Hospital, Baltimore, MD, ²Johns Hopkins Home Care Group, Baltimore, MD, ³Thomas Jefferson Univeristy Hospital, Philadelphia, PA
*Purpose: The availability and high efficacy of direct acting antivirals (DAAs) to treat hepatitis C (HCV) is changing practice in solid organ transplant. A large…
2020 American Transplant Congress
Urinary APOA4 as a Biomarker for Chronic Renal Allograft Injury and Rapid Renal Function Decline in Kidney Transplant Recipients
H. Jeon¹, D. Shin¹, J. Oh¹, J. Park², K. Ko³, J. Kim³, S. Lee³
¹Department of Internal Medicine, Hallym University College of Medicine, Kangdong Sacred Heart Hospital, Seoul, Korea, Republic of, ²Department of Laboratory Medicine, Hallym University College of Medicine, Kangdong Sacred Heart Hospital, Seoul, Korea, Republic of, ³Department of Surgery, Hallym University College of Medicine, Kangdong Sacred Heart Hospital, Seoul, Korea, Republic of
*Purpose: Chronic renal allograft injury (CRAI) remains a major cause of allograft loss in kidney transplant recipients (KTRs). The aim of this study was to…
2020 American Transplant Congress
Mass Cytometry-Based Immunoprofiling as a Tool to Predict Rejection in a Large Cohort of Pediatric Transplant Recipients
M. Rao¹, J. T. Harden², M. Lapasaran², C. O. Esquivel³, O. M. Martinez², S. M. Krams²
¹Pediatrics, Stanford University, Palo Alto, CA, ²Stanford University School of Medicine, Stanford, CA, ³Surgery and Pediatrics, Stanford University School of Medicine, Stanford, CA
*Purpose: Rejection remains a serious problem in the pediatric transplant population. Early detection remains a challenge; furthermore, the changes in immune makeup which accompany rejection…
2020 American Transplant Congress
Accelerated Decline in Glomerular Density: An Unrecognized Pathologic Process after Kidney Transplantation
A. Denic, B. H. Smith, W. D. Park, M. V. Luhman, M. P. Alexander, A. D. Rule, M. D. Stegall
Mayo Clinic, Rochester, Rochester, MN
*Purpose: Studies in healthy adults have shown that glomerular density slowly declines with older age (-0.5% per decade), and globally sclerotic glomeruli (GSG) slowly increase…
2020 American Transplant Congress
Role of Cell Free DNA (Allosure) Testing in Recipients of Kidneys with Sub Optimal Donor Quality
Y. A. Qazi, W. Mon, M. Smogorzewski
USC, Los Angeles, CA
*Purpose: The purpose of this study was to evaluate the role of cell-free DNA testing ( Allosure, CareDx, Brisbane , CA) during graft dysfunction in…
2020 American Transplant Congress
Non-HLA Antibodies in Severe Post-Operative Thrombotic Microangiopathy among Kidney Transplant Recipients
R. Bonakdar, P. Serrano Rodriguez
University of North Carolina Hospitals, Chapel Hill, NC
*Purpose: From August 2018 until July 2019, an alarming 6% of kidney transplant recipients at this transplant center had biopsy-proven thrombotic microangiopathy (TMA) within 1…
2020 American Transplant Congress
Two Pilot Studies Exploring the Diagnostic and Predictive Potential of Serum LAG3 and FGL1 in Kidney Transplant Recipients
Y. Li¹, L. Yan¹, Y. Li¹, C. Yang¹, Z. Wan¹, Y. An¹, Y. Bai¹, L. Wang¹, Y. Shi²
¹Department of Laboratory Medicine, West China Hospital, Chengdu, China, ²Department of Nephrology, West China Hospital, Chengdu, China
*Purpose: Lymphocyte activation gene 3 (LAG3), an immune checkpoint, plays an important role in the negative regulation of immune response and the induction of immune…
2020 American Transplant Congress
Utility of dd-cfDNA in TCMR 1A and Borderline Allograft Rejection
E. Stites¹, D. Kumar², O. Olaitan³, G. Gupta²
¹University of Colorado, Aurora, CA, ²Virginia Commonwealth University, Richmond, VA, ³Rush University, Chicago, CA
*Purpose: The value of donor-derived cell-free DNA (dd-cfDNA, AlloSure) as a molecular marker for the early diagnosis of mild T-cell mediated rejection (Banff TCMR 1A…