Abstracts Archive - Page 444 of 1683 - ATC Abstracts

2020 American Transplant Congress
Kidney Cortical Wedge Biopsies for Human Organ Research: Does Anatomic Variability Impact Their Utility?
C. M. Edwards¹, J. T. Langford¹, M. Reschke², J. R. DiRito¹, D. Mulligan¹, D. Haakinson¹, G. T. Tietjen¹
¹Surgery, Yale School of Medicine, New Haven, CT, ²Biomedical Engineering, Yale University, New Haven, CT
*Purpose: The purpose of this study is to characterize human kidney anatomic variability both within singular biopsies and between biopsy sites in order to investigate…
2020 American Transplant Congress
Noninvasive Detection of Subclinical Rejection in Urine RNA
K. S. Keslar¹, D. Margeta¹, J. J. Friedewald², M. Abecassis², R. B. Mannon³, P. S. Heeger⁴, R. L. Fairchild¹
¹Cleveland Clinic, Cleveland, OH, ²Northwestern University, Chicago, IL, ³University of Alabama at Birmingham, Birmingham, AL, ⁴Icahn School of Medicine, New York, NY
*Purpose: Subclinical rejection may lead to long-term graft injury and can currently only be detected by repeated biopsies. A noninvasive method is needed to monitor…
2020 American Transplant Congress
Two Pilot Studies Exploring the Diagnostic and Predictive Potential of Serum LAG3 and FGL1 in Kidney Transplant Recipients
Y. Li¹, L. Yan¹, Y. Li¹, C. Yang¹, Z. Wan¹, Y. An¹, Y. Bai¹, L. Wang¹, Y. Shi²
¹Department of Laboratory Medicine, West China Hospital, Chengdu, China, ²Department of Nephrology, West China Hospital, Chengdu, China
*Purpose: Lymphocyte activation gene 3 (LAG3), an immune checkpoint, plays an important role in the negative regulation of immune response and the induction of immune…
2020 American Transplant Congress
Development and Cell Surface Testing of a Novel Nanofiber Technology for Targeted Delivery of Therapeutic Regulatory T Cells
J. M. Mathew¹, S. Lee², Y. Sambandam¹, L. A. Fraser², T. D. Clemons², A. Kolberg², J. He¹, L. C. Palmer², M. T. McClendon², Z. J. Zhang¹, J. R. Leventhal¹, S. I. Stupp², L. Gallon¹
¹Surgery -Transplant, Northwestern University, Chicago, IL, ²Simpson Querrey Institute, Northwestern University, Chicago, IL
*Purpose: Regulatory CD4+CD25+FOXP3+ T cells (Tregs) have been shown to induce tolerance in transplantation models, and to be increased in their numbers in tolerant human…
2020 American Transplant Congress
Hypothermia Attenuates Renal Fibrosis after Renal Ischemia Reperfusion in Mice
D. Choi¹, D. Kim², E. Kim², J. Jeong², J. Kim¹, Y. Ham¹, Y. Chang³, K. Na¹, K. Lee¹
¹Nephrology, Chungnam National University, Daejeon, Korea, Republic of, ²Department of Medical Science, Chungnam National University, Daejeon, Korea, Republic of, ³Nephrology, Catholic University of Korea, Daejeon, Korea, Republic of
*Purpose: Recently, acute kidney injury is a important cause of chronic kidney injury, characterized by glomerular sclerosis and tubular fibrosis. Hypothermia attenuates the acute kidney…
2020 American Transplant Congress
Ischemic and Perfused Kidney Treated with Non-Cultured Adipose-Derived Regenerative Cells Increase the Immune and Regulatory Transcriptome
R. Lathan¹, R. Ghita¹, R. Touyz¹, M. Clancy², P. Mark¹
¹Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom, ²Renal Transplant Unit, Queen Elizabeth University Hospital, Glasgow, United Kingdom
*Purpose: Studies in our rat model of ischemic reperfusion injury (IRI) demonstrate improved kidney function post injection of non-cultured autologous adipose-derived regenerative cells (ADRC). The…
2020 American Transplant Congress
Treg Stability Depends on Lymphotoxin Beta Receptor-Driven Migration
V. Saxena, W. Piao, L. Li, Y. Xiong, C. Palusckievicz, T. Simon, M. Shirkey, R. Abdi, J. S. Bromberg
University of Maryland, Baltimore, Baltimore, MD
*Purpose: Regulatory T cell (Treg) suppressor function for allograft survival requires maintenance of transcription factor Foxp3 and sequential migration from tissues to lymph nodes (LN).…
2020 American Transplant Congress
Gal9/Tim-3 Pathway was Required for Endometrial Stem Cells to Induce Peripheral Tolerance of Cardiac Allograft
Y. Zhao¹, Y. Hu¹, D. Yu¹, X. Li¹, W. Jin¹, Y. Qin¹, D. Kong¹, H. Wang¹, A. Alessandrini², H. Wang¹
¹Tianjin Medical University General Hospital, Tianjin, China, ²Massachusetts General Hospital, Boston, MA
*Purpose: The existing immunosuppressants seem to have little effect on Cardiac Allograft Vasculopathy but with obvious side effects. ERCs (Endometrial stem Cells), which are mesenchymal-like…
2020 American Transplant Congress
Antibody-Suppressor CD8⁺ T Cells Ameliorate Antibody-Mediated Rejection Following Kidney Transplant in Mice
J. M. Zimmerer¹, J. L. Han¹, Q. Zeng², B. A. Ringwald¹, C. Cassol¹, R. Warren¹, M. Abdel-Rasoul¹, C. K. Breuer², G. L. Bumgardner¹
¹Ohio State University, Columbus, OH, ²Nationwide Children's Hospital, Columbus, OH
*Purpose: We previously reported the novel alloantibody suppressor activity of alloprimed CXCR5+IFN-γ+CD8+ T cells following hepatocellular transplant in mice. We utilized a murine kidney transplant…
2020 American Transplant Congress
Abdominal Multiorgan Retrieval from Pigs in a Slaughterhouse: A Reliable and Efficient Donation after Circulatory Death Model for Ex Vivo Organ Perfusion
F. Neri, F. Dengu, G. Ebeling, L. Knijff, K. Rozemberg, J. Branchereau, P. Friend, R. Ploeg, J. Hunter
Nuffield Department of Surgical Sciences, Oxford University, Oxford, United Kingdom
*Purpose: Advances in organ perfusion technology have been driven by the increasing necessity to utilise organs from donors after circulatory death (DCD) and marginal donors.…