Abstracts Archive - Page 442 of 1683 - ATC Abstracts

2020 American Transplant Congress
Utility of dd-cfDNA in TCMR 1A and Borderline Allograft Rejection
E. Stites¹, D. Kumar², O. Olaitan³, G. Gupta²
¹University of Colorado, Aurora, CA, ²Virginia Commonwealth University, Richmond, VA, ³Rush University, Chicago, CA
*Purpose: The value of donor-derived cell-free DNA (dd-cfDNA, AlloSure) as a molecular marker for the early diagnosis of mild T-cell mediated rejection (Banff TCMR 1A…
2020 American Transplant Congress
Pancreas Transplants in Asian Recipients
A. Gruessner, C. Gruessner, S. Saggi, J. Renz
SUNY Downstate Medical Center, Brooklyn, NY
*Purpose: Over the years, a change in patients receiving a pancreas transplant could be observed. While in the beginning the standard pancreas transplant recipient was…
2020 American Transplant Congress
Mechanisms by Which Donor Bone-Marrow CXCR4+ Foxp3+ Tregs Promote Long-Term Survival of Murine Limb Allografts
L. Wang¹, Z. Wang², R. Han¹, A. Samanta¹, G. Ge¹, L. S. Levin¹, M. H. Levine¹, W. W. Hancock³
¹Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, ²University of Pennsylvania, Philadelphia, PA, ³Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA
*Purpose: Vascularized composite allotransplantation (VCA) allows tissue replacement after devastating loss but is currently limited in application and may be more widely performed if maintenance…
2020 American Transplant Congress
Ex-Vivo Perfusion with UW Cold Storage Solution Improves DCD Rat Liver Preservation
R. Fyffe-Freil, N. Wickramaratne, J. Khoraki, H. Kang, C. Chmielewski, R. Li, M. J. Mangino
Surgery, Virginia Commonwealth University, Richmond, VA
*Purpose: The donor pool of livers can be expanded by the successful use of donor livers recovered under DCD conditions. It is assumed that perfusion…
2020 American Transplant Congress
Genome-Wide Transcriptome Analysis of Extreme Marginal Renal Grafts Indicates Earlier Repair and Less Damage Following Normothermic Ex-Vivo Kidney Perfusion Preservation
P. Urbanellis¹, L. Mazilescu¹, C. McEvoy¹, S. Ganesh¹, R. John¹, I. Mucsi¹, A. Ghanekar¹, D. Bagli², A. Konvalinka¹, L. Robinson¹, M. Selzner¹
¹University Health Network, Toronto, ON, Canada, ²The Hospital for Sick Children, Toronto, ON, Canada
*Purpose: Normothermic ex-vivo kidney perfusion (NEVKP) was shown to prevent delayed graft function of kidneys subjected to prolonged warm ischemia (WI) compared to static cold…
2020 American Transplant Congress
Filgrastim Utilization Evaluation in Solid Organ Transplant Recipients
O. Witkowsky, L. Stanz, K. Schnelle
The Ohio State University Wexner Medical Center, Columbus, OH
*Purpose: Neutropenia occurs in up to 40% of kidney and liver transplant (txp) recipients and has been associated with higher mortality rates in liver txp.…
2020 American Transplant Congress
Kidney Cortical Wedge Biopsies for Human Organ Research: Does Anatomic Variability Impact Their Utility?
C. M. Edwards¹, J. T. Langford¹, M. Reschke², J. R. DiRito¹, D. Mulligan¹, D. Haakinson¹, G. T. Tietjen¹
¹Surgery, Yale School of Medicine, New Haven, CT, ²Biomedical Engineering, Yale University, New Haven, CT
*Purpose: The purpose of this study is to characterize human kidney anatomic variability both within singular biopsies and between biopsy sites in order to investigate…
2020 American Transplant Congress
Normothermic Machine Perfusion of Rat Liver: Comparing Two Perfusion Methods
F. Zhou, M. Xu, O. Ahmed, G. A. Upadhya, Y. Lin, W. C. Chapman
Surgery, Washington University in St. Louis, St. Louis, MO
*Purpose: Isolated perfused rodent liver (IPRL) model has gained popularity in ex-vivo rat liver preservation and pharmacological intervention studies. Experimental conditions and system layouts vary…
2020 American Transplant Congress
Cordycepin Protects Renal Ischemia/Reperfusion Injury Through Regulating Inflammation, Apoptosis and Oxidative Stress
C. Ding, W. Xue
Department of Renal Transplantation, The First Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China
*Purpose: Cordycepin (3’-deoxyadenosine) is a naturally occurring adenosine analogue and onem of the bioactive constituents isolated from Cordyceps militaris/Cordyceps sinensis, species of the fungal genus…
2020 American Transplant Congress
Multimodal Theranostic Nanocolloid Platform for Imaging, Targeted Drug Delivery and Organ Preservation in Transplantation
J. M. Janjic¹, E. Lambert¹, L. Liu¹, M. Herneisey¹, V. S. Gorantla²
¹School of Pharmacy, Chronic Pain Research Consortium, Duquesne University, Pittsburgh, PA, ²Wake Forest Institute for Regenerative Medicine, Winston- Salem, NC
*Purpose: The goal of this project design and development of multifunctional nanomedicines to address unique and complex therapeutic outcomes in transplantation and organ preservation. Presented…