2020 American Transplant Congress
Protective Effect of Fucoidan Against Tacrolimus-Induced Nephrotoxicity in LLC-PK1 Cells
Surgery, University of Ulsan, Gangneung Asan Hospital, Gangneung, Korea, Republic of
*Purpose: Tacrolimus (FK506) is an immunosuppressant agent that is frequently used to prevent rejection of solid organs upon transplant. However, nephrotoxicity due to apoptosis and…2020 American Transplant Congress
Autophagy Attenuates Renal Allograft Interstitial Fibrosis by Regulating the EndMT Induced by TNF-α
Jiangsu Province Hospital, Nanjing, China
*Purpose: Kidney interstitial fibrosis is a significant cause of allograft failure in kidney transplantation. Autophagy is a self-digestive process that eliminates impaired or aged proteins…2020 American Transplant Congress
Synergistic Anticancer Effect of Metformin in Combination with Immunosuppressant on Hepatocellular Carcinoma Cell Lines
*Purpose: After liver transplantation (LT), immunosuppression is needed to avoid rejection and graft loss, however, it can stimulate hepatocellular carcinoma (HCC) recurrence and progression. Previous…2020 American Transplant Congress
Targeting CD4+ T Cell Metabolism Prolongs Graft Survival Age-Specifically
*Purpose: If and how aging affects T-cell metabolism and alloimmune response is unclear. Here, we show that T-cell metabolism changes drastically in aging. Most notably,…2020 American Transplant Congress
Epidemiology of Clostridioides Difficile Infection in Intestinal and Multivisceral Transplant Patients at a Single Transplant Center
*Purpose: Solid organ transplant (SOT) recipients face increased risk of Clostridioides difficile infection (CDI), with reported CDI incidence of 7.4%-20% far exceeding that of the…2020 American Transplant Congress
Improvements in Organ Donation: Riding the Coattails of a National Tragedy
1Medicine, University of Miami, Miami, FL, 2Emory University, Atlanta, GA
*Purpose: The US organ donation system has received attention from the highest levels of government. It has been debated whether increased donation is attributable solely…2020 American Transplant Congress
The Prevalence of Preemptive Transplantation at a Large Volume Kidney Transplant Center
1Houston Methodist Research Institute, Houston, TX, 2Houston Methodist Hospital, Houston, TX
*Purpose: In the wake of the Executive Order on Advancing American Kidney Health, it is essential to fully examine the current care paradigm for chronic…2020 American Transplant Congress
Making History, Saving Lives: One OPOs Experience Making History by Being the First in the Nation to Successfully Allocate Seven Organs for Transplant from a Donation after Circulatory Death (DCD) Donor
LifeShare Transplant Donors Services, Oklahoma City, OK
*Purpose: At the time of this recovery, our OPO’s percentage of DCD donors was 41%. Continuing to maximize the gift successfully by increasing the percentage…2020 American Transplant Congress
Src Induces Endothelial-to-Mesenchymal Transition and Renal Allograft Fibrosis via Promoting WNT/β-catenin Pathway
Jiangsu Province Hospital, Nanjing, China
*Purpose: Endothelial-to-mesenchymal(EndMT)is recognized as an important source of myofibroblasts contributing to the pathogenesis of allograft interstitial fibrosis in our previous studies. Increased proto-oncogene tyrosine-protein kinase…2020 American Transplant Congress
Evaluating Postoperative Opioid Requirements of Kidney Transplant Recipients
*Purpose: Multimodal analgesia with non-opioid analgesics in the setting of enhanced recovery after surgery (ERAS) pathway has proven beneficial in managing pain and decreasing adverse…
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