Abstracts Archive - Page 399 of 1683 - ATC Abstracts

2020 American Transplant Congress
Protective Effect of Fucoidan Against Tacrolimus-Induced Nephrotoxicity in LLC-PK1 Cells
H. J. Jang
Surgery, University of Ulsan, Gangneung Asan Hospital, Gangneung, Korea, Republic of
*Purpose: Tacrolimus (FK506) is an immunosuppressant agent that is frequently used to prevent rejection of solid organs upon transplant. However, nephrotoxicity due to apoptosis and…
2020 American Transplant Congress
Targeting CD62 – CD162 Signaling with a Soluble Form of a Tandem-PSGL-1 in a Murine Model of Hindlimb Transplantation
K. Kadono¹, F. Messner², Y. Guo², B. Oh², G. Brandacher², J. W. Kupiec-Weglinski¹
¹Liver Transplant Surgery, UCLA, Los Angeles, CA, ²Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD
*Purpose: Static cold storage (SCS) times for organs and tissues are currently limited to hours. Once outside the body, tissues lack oxygen and nutrient supply…
2020 American Transplant Congress
Novel Technique to Analyze Blood-Endothelial Cell Interactions Under Flow Conditions
M. R. Connolly¹, K. Petitpas¹, L. Burdorf¹, B. Cerel¹, C. Laird², D. Harris², A. Azimzadeh¹, R. N. Pierson III¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²University of Maryland, Baltimore, Baltimore, MD
*Purpose: The Bioflux system has been used to study platelet-driven thrombosis and leukocyte adhesion. Typically, whole blood is stained with calcein (green) to evaluate platelet…
2020 American Transplant Congress
Synergistic Anticancer Effect of Metformin in Combination with Immunosuppressant on Hepatocellular Carcinoma Cell Lines
S. Suh¹, Y. Choi¹, K. Lee²
¹Surgery, Chung-Ang University, College of Medicine, Seoul, Korea, Republic of, ²Surgery, Seoul National University College of Medicine, Seoul, Korea, Republic of
*Purpose: After liver transplantation (LT), immunosuppression is needed to avoid rejection and graft loss, however, it can stimulate hepatocellular carcinoma (HCC) recurrence and progression. Previous…
2020 American Transplant Congress
ANG-3777, A Hepatic Growth Factor Mimetic, Attenuates Post-Transplant Renal Dysfunction in Rats
P. Narayan, I. D. Goldberg
Angion Biomedica, Uniondale, NY
*Purpose: ANG-3777, a small-molecule mimetic of hepatocyte growth factor (HGF), has the potential to exert antifibrotic and nephroprotective effects. A rat model of renal transplantation…
2020 American Transplant Congress
Epidemiology of Clostridioides Difficile Infection in Intestinal and Multivisceral Transplant Patients at a Single Transplant Center
A. Modi¹, B. Gonzalez², K. Brizendine¹
¹Infectious Disease, Cleveland Clinic, Cleveland, OH, ²Pediatric Infectious Disease, Cleveland Clinic, Cleveland, OH
*Purpose: Solid organ transplant (SOT) recipients face increased risk of Clostridioides difficile infection (CDI), with reported CDI incidence of 7.4%-20% far exceeding that of the…
2020 American Transplant Congress
What is the Significance of Denovo Donor Specific Antibodies in Recipients of Simultaneous Liver-Kidney Transplants?
S. Parajuli, F. Aziz, J. Blazel, B. Muth, N. Garg, M. Mohamed, J. Rice, J. Mezrich, L. Hidalgo, D. Mandelbrot, G. Im, B. Lee
University of Wisconsin, Madison, WI
*Purpose: There is limited information about the utility of donor-specific HLA antibody (DSA) testing and the role of protocol kidney biopsy for de-novo donor-specific antibodies…
2020 American Transplant Congress
Making History, Saving Lives: One OPOs Experience Making History by Being the First in the Nation to Successfully Allocate Seven Organs for Transplant from a Donation after Circulatory Death (DCD) Donor
J. B. Nave, A. J. Boyer, C. A. Hostetler, C. C. Muse, R. A. Squires, J. P. Orlowski
LifeShare Transplant Donors Services, Oklahoma City, OK
*Purpose: At the time of this recovery, our OPO’s percentage of DCD donors was 41%. Continuing to maximize the gift successfully by increasing the percentage…
2020 American Transplant Congress
Enhanced Recovery after Surgery Reduces Length of Hospital Stay in Renal Transplant Recipients
S. O'Neill, T. Brown, J. McCaughan, A. Courtney
Department of Transplantation, Belfast City Hospital, Belfast, United Kingdom
*Purpose: Enhanced recovery after surgery (ERAS) is an established multimodal approach to perioperative care. However, ERAS in renal transplantation isn’t common practice. ERAS involving early…
2020 American Transplant Congress
Evaluating Postoperative Opioid Requirements of Kidney Transplant Recipients
M. A. Muir¹, K. R. Szempruch², R. E. Dupuis¹, A. H. Toledo³, P. Serrano Rodriguez³
¹Pharmacotherapy and Experimental Therapeutics, UNC Eshleman School of Pharmacy, Chapel Hill, NC, ²Pharmacy, UNC Medical Center, Chapel Hill, NC, ³Surgery - Transplant, UNC Medical Center, Chapel Hill, NC
*Purpose: Multimodal analgesia with non-opioid analgesics in the setting of enhanced recovery after surgery (ERAS) pathway has proven beneficial in managing pain and decreasing adverse…