2020 American Transplant Congress
Evolution of Molecular MMDx Scores after Kidney Transplantationin Different Donor Categories
*Purpose: The outcome of kidney transplantation is highly affected by donor category. Little is known about molecular processes which may underline this phenomenon.*Methods: Using Molecular…2020 American Transplant Congress
Perfusion Regulated Organ Therapeutics with Enhanced Controlled Testing (PROTECT): Novel Human Model to Mitigate Ischemia-Reperfusion Injury in Liver Transplant
Saint Louis University, Saint Louis, MO
*Purpose: Despite a global organ shortage, there is almost a 10% discard rate of ‘marginal donor livers’ (MDL), deemed unsuitable for transplantation due to the…2020 American Transplant Congress
Effect of Hepatic Steatosis on Hepatic Ischemia-Reperfusion Induced Acute Kidney Injury in Mice
*Purpose: Livers with mild to moderate steatosis have been used to expand the donor pool for transplantation. However, livers with steatosis have a propensity for…2020 American Transplant Congress
Pattern of Renal Allograft Injury in Recipients with Normal Donor-Derived Cell-Free DNA
University of Maryland School of Medicine, Baltimore, MD
*Purpose: Donor-derived cell-free DNA (dd-cfDNA) is a novel non-invasive test currently used as a biomarker for identification of transplant rejection or injury. Here, we sought…2020 American Transplant Congress
Increased Post-Operative Ventilation Time in Lung Transplant Recipients with Left Ventricular Diastolic Dysfunction
*Purpose: Left ventricular diastolic dysfunction has been shown to be associated with increased morbidity in bilateral lung transplant recipients with pulmonary artery hypertension. It has…2020 American Transplant Congress
Outreach as a Way to Improve Access to Kidney Transplants: A Model to Align with Future of Kidney Disease Care
1Univ of Cincinnati, Cincinnati, OH, 2UC Health, Cincinnati, OH
*Purpose: In 2018, there were more than 100,000 patients wait-listed for kidney transplant whereas only around 21,000 patients received a kidney transplant. Increasing access to…2020 American Transplant Congress
Altering Homeostatic Repopulation with Thymic Irradiation and Donor Mesenchymal Stem Cell Infusions in a Nonhuman Primate Model
Department of Surgery, Duke University Medical Center, Durham, NC
*Purpose: Lymphocyte depletion and subsequent homeostatic repopulation present opportunities to shape the alloreactive immune repertoire to favor tolerance. We tested if the addition of thymic…2020 American Transplant Congress
Targeting CD4+ T Cell Metabolism Prolongs Graft Survival Age-Specifically
*Purpose: If and how aging affects T-cell metabolism and alloimmune response is unclear. Here, we show that T-cell metabolism changes drastically in aging. Most notably,…2020 American Transplant Congress
In Vivo Phosphorylation of C-MET by ANG-3777, A Hepatocyte Growth Factor Mimetic
Angion Biomedica, Uniondale, NY
*Purpose: : The biological effects of hepatocyte growth factor/scatter factor (HGF) and its mimetics are mediated by a signal cascade initiated by binding of HGF…2020 American Transplant Congress
ESAT-6, A Novel Protein Originally Produced by M. Tuberculosis, Inhibits Central Memory CD8+ T Cell Generation and Allograft Rejection
Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China
*Purpose: Allospecific memory T cells pose a threat to long-term allograft survival since they are somewhat resistant to immunosuppression. The objective of this study is…
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