2020 American Transplant Congress
Evolution of Molecular MMDx Scores after Kidney Transplantationin Different Donor Categories
*Purpose: The outcome of kidney transplantation is highly affected by donor category. Little is known about molecular processes which may underline this phenomenon.*Methods: Using Molecular…2020 American Transplant Congress
Therapeutic Inhibition of Spleen Tyrosine Kinase Decreases Hepatic Damage after Ischemia Reperfusion Injury
Surgery, University of Florida, Gainesville, FL
*Purpose: Hepatic ischemia/reperfusion injury (IRI) is a major challenge in transplantation. The complex array of interrelated signaling events in IRI have been studied individually, but…2020 American Transplant Congress
Protection Role of microRNA let-7 in Hepatic Ischemia Reperfusion Injury by Inhibiting JAK-STAT3 Pathway
*Purpose: Ischemia reperfusion injury (IRI) is an inevitable event in conventional organ transplant procedure and affects the prognosis in post-transplantation. Increasing evidence suggests that microRNA…2020 American Transplant Congress
Effect of Hepatic Steatosis on Hepatic Ischemia-Reperfusion Induced Acute Kidney Injury in Mice
*Purpose: Livers with mild to moderate steatosis have been used to expand the donor pool for transplantation. However, livers with steatosis have a propensity for…2020 American Transplant Congress
Early Tacrolimus-LCP Conversion Due to Adverse Effects in Pancreas Transplant Recipients Improves Tolerance But Not Graft Survival
*Purpose: Tacrolimus-LCP (LCPT) is an extended release formulation of tacrolimus which has been shown to have fewer adverse drug effects (ADE) than immediate release tacrolimus…2020 American Transplant Congress
Increased Post-Operative Ventilation Time in Lung Transplant Recipients with Left Ventricular Diastolic Dysfunction
*Purpose: Left ventricular diastolic dysfunction has been shown to be associated with increased morbidity in bilateral lung transplant recipients with pulmonary artery hypertension. It has…2020 American Transplant Congress
The 1st Year Posttransplant Course Reliably Predicts Kidney Graft Survival up to 15 Years Using a Machine Learning-Based Modeling Approach
Hannover Medical School, Hannover, Germany
*Purpose: Identification of patients at risk for graft failure can improve individual surveillance and early therapeutic interventions. We used a well-documented patient cohort to establish…2020 American Transplant Congress
Targeting CD4+ T Cell Metabolism Prolongs Graft Survival Age-Specifically
*Purpose: If and how aging affects T-cell metabolism and alloimmune response is unclear. Here, we show that T-cell metabolism changes drastically in aging. Most notably,…2020 American Transplant Congress
Depletional Profiles of Human and Rhesus Specific Anti-Thymocyte Globulins in Rhesus Macaques
*Purpose: Rabbit anti-human ATG (rATG; Thymoglobulin®) is the most commonly used formulation for depletional induction therapy in the United States. However, given that it is…2020 American Transplant Congress
ANG-3777 Treatment Attenuates Ischemia-Reperfusion-Induced Renal Injury in Rat and Dog Models
1Angion Biomedica, Uniondale, NY, 2Virginia Commonwealth University, Richmond, VA
*Purpose: The effect of ANG-3777, a small-molecule mimetic of hepatocyte growth factor, was evaluated on reducing ischemia-reperfusion-induced renal injury and mortality in rats and dogs…
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