Abstracts Archive - Page 351 of 1683 - ATC Abstracts

2020 American Transplant Congress
Attempted Validation of Lims1 Variant Rs893403 with Acute Rejection Risk
W. S. Oetting¹, G. Weihua¹, C. R. Dorr¹, R. B. Mannon², A. J. Matas¹, P. A. Jacobson¹, A. K. Israni¹
¹University of Minnesota, Minneapolis, MN, ²University of Alabama, Birmingham, AL
*Purpose: Acute rejection (AR) in kidney allograft recipients is a significant risk factor for reduced graft survival. Identifying individuals at risk for AR could facilitate…
2020 American Transplant Congress
A Mouse Model of Paratopic Intestinal Transplantation to Delineate GVHD-Free Alloimmune Rejection Responses
A. Dangi¹, J. Wang², A. Joseph³, J. Roper³, N. Surana⁴, X. Luo¹
¹Nephrology/Medicine, Duke University, Durham, NC, ²Surgery, Duke University, Durham, NC, ³Gastroenterology/Medicine, Duke University, Durham, NC, ⁴Molecular Genetics and Microbiology, Duke University, Durham, NC
*Purpose: Current clinical practice of intestinal transplantation is limited due to a high rate of graft failure and patient mortality. In the present study, we…
2020 American Transplant Congress
Five Year Patient Important Outcomes of Treated Acute Rejections Diagnosed with Protocol and Clinical Biopsy after Pancreas Transplant Alone for Type 1 Diabetes
Y. C. Kudva, S. R. Rizvi, R. Kaur, B. H. Smith, S. Batthula, P. G. Dean, A. Kukla, W. K. Kremers, M. D. Stegall
Mayo Clinic, Rochester, MN
*Purpose: STUDY PURPOSE: Acute rejection (AR) after Pancreas Transplant alone (PTA) continues to be a significant morbidity. We compared the outcomes of PTA recipients treated…
2020 American Transplant Congress
Characterization of an Integrative Prognostic Score for US Patients Taken from the DART Study
J. Bromberg¹, R. Bloom², P. Sood³
¹University of Maryland, Baltimore, MD, ²Penn Medicine, Philadelphia, PA, ³University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: iBox is a validated cloud-based software as a service (SaaS) algorithm that provides a predictive analysis of the post-transplant patient, quantifying the risk of…
2020 American Transplant Congress
Ifnar Signaling on Myeloid Cells Does Not Contribute to Costimulation Independent Transplant Rejection
J. Habib, D. Mathews, Y. Dong, A. Stephenson, A. Adams
Emory University, Atlanta, GA
*Purpose: Costimulation blockade (CoB) is a promising new strategy that provides a more targeted therapy with fewer side effects compared to traditional transplant immunosuppressants, leading…
2020 American Transplant Congress
Natural Course of Borderline Changes in Kidney Allografts: A MMDx Study
P. Hruba¹, K. S. Madill-Thomsen², M. Mackova², J. Maluskova³, E. Honsova³, J. Slatinska⁴, P. F. Halloran², O. Viklicky⁴
¹Transplant Laboratory, IKEM, Prague, Czech Republic, ²ATAGC, University of Alberta, Edmonton, AB, Canada, ³Department of Pathology, IKEM, Prague, Czech Republic, ⁴Department of Nephrology, IKEM, Prague, Czech Republic
*Purpose: Molecular assessment of kidney allograft biopsies with Banff borderline changes (BL) category has showed only 30% of rejection phenotype in various post-transplant follow-up and…
2020 American Transplant Congress
Bariatric Surgery for Congestive Heart Failure Patients Improves Access to Transplantation and Long-Term Survival
R. A. Choudhury¹, G. Hoeltzel², H. B. Moore¹, H. Yaffe¹, D. Yoeli¹, K. R. Dumon³, K. D. Conzen¹, T. L. Nydam¹
¹Department of Surgery- Division of Transplantation Surgery, University of Colorado Hospital, Aurora, CO, ²Thomas Jefferson University Hospital, Philadelphia, PA, ³Department of Surgery, University of Colorado Hospital, Philadelphia, PA
*Purpose: Obese patients with congestive heart failure (CHF) are often denied access to heart transplantation until they obtain significant weight loss to achieve a certain…
2020 American Transplant Congress
Machine Learning Model Outperforms Linear Regression Models for 1- and 3-Year Post-Transplant Survival: Is This the Future?
R. W. Pettit¹, S. J. Corr², J. Havelka³, A. Rana¹
¹Baylor College of Medicine, Houston, TX, ²Interdisciplinary Surgical Technology and Innovation Center, Baylor College of Medicine, Houston, TX, ³InformAI, Houston, TX
*Purpose: Modeling is essential for regulatory oversight and risk stratification in clinical practice. Our hypothesis was that machine learning models would be superior to linear/logistic…
2020 American Transplant Congress
The Role of Complement-Split Products as Biomarkers for Acute Antibody-Mediated Rejection of Kidney Allografts
B. G. Abu Jawdeh¹, B. Campos-Naciff¹, K. Harrison¹, K. Meganathan¹, A. Kumar², M. Anand¹, A. Govil¹, E. S. Woodle¹, B. P. Dixon³
¹University of Cincinnati, Cincinnati, OH, ²All India Institute of Medical Sciences, New Delhi, India, ³University of Colorado, Aurora, CO
*Purpose: Acute antibody-mediated rejection (AMR) is mediated by the activation of the classical complement system in addition to non-complement dependent inflammatory pathways. Complement fixation by…
2020 American Transplant Congress
Transpulmonary Gradient as a Predictor for Outcomes after Single Lung Transplantation in Patients with Pulmonary Hypertension
A. Madde¹, E. Chan², J. Ryan², P. Reck Dos Santos², M. Morrell³, J. Luketich², P. Sanchez²
¹University of Pittsburgh School of Medicine, Pittsburgh, PA, ²UPMC Department of Cardiothoracic Surgery, Pittsburgh, PA, ³UPMC Division of Pulmonary Medicine, Pittsburgh, PA
*Purpose: End stage lung disease is commonly associated with pulmonary artery hypertension (PAH). In a donor restrictive environment, offering patients single over double lung transplants…