2021 American Transplant Congress
Alloreactive Memory T Follicular Helper Cells Rapidly Differentiate Into Effectors Independent of B Cell Memory Following Retransplantation
Department of Surgery, Emory, Atlanta, GA
*Purpose: Donor-directed HLA antibodies are an important cause of renal allograft injury, but effective therapeutic options to prevent or eliminate donor-specific antibodies (DSA) do not…2021 American Transplant Congress
K562 Cells Expressing HLA-A2 Stimulate Alloreactive CD8+ T Cells
Emory Transplant Center, Emory University, Atlanta, GA
*Purpose: T cell-mediated rejection is a significant factor that leads to graft damage and loss in transplant recipients. Due to the complexity of the TCR:pMHC…2021 American Transplant Congress
CRISPR Screens to Map CTLA-4 Regulatory Networks in Primary Human T Cells
1UCSF, San Francisco, CA, 2Stanford University, Stanford, CA
*Purpose: For most cell types, the pathways that regulate the levels of critical disease-relevant genes are not known. Recent advances in gene editing have enabled…2021 American Transplant Congress
Tip60 Inhibitors Enhance Regulatory T Cells (Treg) Induction by Promoting Acetylation of Foxp3
*Purpose: TIP60, a histone/protein acetyltransferase essential for multiple functions in the cell, is involved in Foxp3 acetylation in Treg. Acetylation protects Foxp3 from degradation, and…2021 American Transplant Congress
Donor Kidney-Resident Macrophages Promote Allograft Inflammation and CD8 T Cell Response Post-Transplantation
*Purpose: Kidney-resident macrophages play important roles in maintaining normal kidney function and promoting prompt repair following kidney injuries. Nevertheless, their fate and role in kidney…2021 American Transplant Congress
Quantifying Hidden Sensitization: HLA-reactive Memory B Cells in the Spleens of Sensitized Women
*Purpose: Measurement of circulating anti-HLA antibody (anti-HLA-Ab) in transplant candidates and recipients is required for successful organ transplantation. However, serum Ab measurement alone likely underestimates…2021 American Transplant Congress
Mhealth Family Self-Management Intervention for Families of Transplanted Children
*Purpose: Nearly 2,000 children undergo solid organ transplant in the US annually. In our previous research with transplant families, parents reported difficulty coping with the…2021 American Transplant Congress
Donor Lymphocytes in Peripheral Blood of Patients After Lung Transplantation Comprise High Frequencies of Killer Cell Immunoglobulin-like Receptor-positive T and NK Cell Subsets
*Purpose: For end-stage lung diseases, lung transplantation (LuTx) is the only curative treatment option. However, acute and chronic rejections are major limitations. Thus, a deeper…2021 American Transplant Congress
Tissue-Specific Features of Immunity Revealed by Single-cell RNA Sequencing of Healthy Human Kidney
*Purpose: Tissue-resident immune cells reside within distinct niches across organs, where they sustain tissue homeostasis and rapidly respond to perturbations in the local microenvironment. Across…2021 American Transplant Congress
Distinct Phenotype and Function of Antibody-suppressor Cxcr5+Cd8+ T Cells
*Purpose: We have reported that the novel subset of antibody-suppressor CD8+ T cells (termed CD8+ TAb-supp cells) require the expression of CXCR5. In addition, alloprimed…
- « Previous Page
- 1
- …
- 317
- 318
- 319
- 320
- 321
- …
- 1683
- Next Page »