Abstracts Archive - Page 314 of 1683 - ATC Abstracts

2021 American Transplant Congress
Value of a Personal Systems Approach in Improving Medication Adherence in Adult Kidney Transplant Patients: A Cost-effectiveness Analysis of the MAGIC Randomized Clinical Trial
M. R. Wakefield¹, M. Whittington², C. Ashbaugh³, L. M. Remy⁴, D. Aholt⁴, C. Miller⁴, D. Hathaway⁵, D. Clark⁵, K. Goggin⁵, R. J. Ellis⁶, C. L. Russell⁴
¹Surgery/Urology, University of Missouri School of Medicine, Columbia, MO, ²University of Kansas Medical Center, Kansas City, KS, ³University of Missouri Health Care, Columbia, MO, ⁴University of Missouri-Kansas City, Kansas City, MO, ⁵Children's Mercy Kansas City, Kansas City, MO, ⁶Indiana University School of Nursing, Indianapolis, IN
*Purpose: The objective of this evaluation was to estimate the cost of implementation and the cost-effectiveness of a person-level intervention called SystemCHANGETM .*Methods: To estimate…
2021 American Transplant Congress
Wave of the Future: Expanding Role and Necessity of the Dedicated Procurement Surgeon
C. Strom, B. Cimsit, H. Nelson, F. Delmonico
New England Donor Services, Waltham, MA
*Purpose: To evaluate the quantitative and qualitative benefits of a dedicated procurement surgeon (DPS) across the transplant spectrum, including the DPS technical performance value for…
2021 American Transplant Congress
The Microenvironment of Belatacept-Resistant Rejection
A. Johnson, J. Zhang, C. Larsen
Surgery, Emory University, Atlanta, GA
*Purpose: Belatacept is a co-stimulation blockade immunosuppressant, that despite demonstrating improved long-term outcomes, has not been widely adopted, in part, due to concern over early…
2021 American Transplant Congress
The Efficacy of Delayed Fc-nonbinding Anti-CD3 Antibody Treatment in Sensitized Allogeneic Mouse Heart Transplantation
T. Ota¹, R. Goto¹, R. Kanazawa¹, K. Shibuya¹, Y. Ganchiku¹, N. Kawamura², M. Watanabe², M. Fukai¹, T. Shimamura³, A. Taketomi¹
¹Dept. of Gastroenterological Surgery I, Hokkaido University, Sapporo, Japan, ²Dept. of Transplant Surgery, Hokkaido University, Sapporo, Japan, ³Division of Organ Transplantation, Hokkaido University Hospital, Sapporo, Japan
*Purpose: Delayed treatment with Fc-nonbinding anti-CD3 antibody (ab) permits early graft infiltrating cells to promotes a transplant tolerance. However, graft infiltrating cells immediate after transplantation…
2021 American Transplant Congress
Belatacept-Resistant T Cells are Activated by IFNα-IRF7 Pathway
F. Herr, K. Bargiel, A. Vernochet, A. Durrbach
UMR1186, Villejuif, France
*Purpose: Second signal of activation play an important role in activation of T lymphocytes. Their control by checkpoint inhibitor is efficient in auto-immune disease and…
2021 American Transplant Congress
Murine Cytomegalovirus Induces Kidney Allograft Injury via Th17 Cells Recruited by Both Viral Antigen-Specific and Cytokine/chemokine Mediated Pathways
R. Dhital¹, V. Velazquez¹, Q. Zeng², B. Graber¹, K. Flint¹, M. Shimamura¹
¹Vaccines and Immunity, Nationwide Children's Hospital, Columbus, OH, ²Center for Cardiovascular Research, Nationwide Children's Hospital, Columbus, OH
*Purpose: Cytomegalovirus infection in transplant recipients has been associated with renal allograft rejection and graft failure. We have previously shown that murine CMV (MCMV) infected…
2021 American Transplant Congress
Invariant Nkt Cells Promote Expansion of Novel Cxcr3⁺Ccr4⁺Cd8⁺ T Cells in the Liver Following Allogeneic Hepatocyte Transplant
J. Zimmerer¹, B. Ringwald², S. Chaudhari¹, J. Han¹, C. M. Peterson¹, R. T. Warren¹, M. Hart¹, M. Abdel-Rasoul³, G. Bumgardner¹
¹OSU, Columbus, OH, ²Medical Student Research Program, OSU, Columbus, OH, ³Center for Biostatistics, OSU, Columbus, OH
*Purpose: Hepatocyte transplantation represents a treatment for metabolic diseases and a bridge therapy to whole organ transplant but is limited in part by cell immunogenicity.…
2021 American Transplant Congress
27 Months Follow Up of a Cohort in the Transplant Continuum After Using a New Electronic Medical Record Tool to Document Transplant Option Discussions Among Patients with EGFR <20 Ml/min/1.73m2
A. A. Yishak¹, M. S. Bhatnagar², A. V. Tomimatsu³, R. La Londe⁴, E. Clark⁵, K. B. Rubenstein⁶, S. Vupputuri⁶
¹MAPMG, McLean, VA, ²Kaiser Permanente |, Oakland, CA, ³Kaiser Permanente, Oakland, CA, ⁴Kaiser Permanente, Oakland,, CA, ⁵Kaiser Permanente, Hyattsville, MD, ⁶MAPRI, Rockville, MD
*Purpose: The purpose of this study was to assess: 1) the documentation of transplant option discussions; 2) the number of members listed & transplanted preemptively;…
2021 American Transplant Congress
Re-Transplantation of Mouse Kidney Grafts to Study Local Immune Responses
D. Zhao, M. Oberbarnscheidt, F. Lakkis, K. Khodor
Starzl Transplantation Institution, Pittsburgh, PA
*Purpose: Mouse kidney transplantation has been widely used to study the immune response to allogeneic grafts. This response includes a circulating systemic compartment and a…
2021 American Transplant Congress
Belatacept and Rapamycin Maintenance Immunosuppression in a Sensitized Nonhuman Primate Kidney Allotransplantation Model
R. Schmitz¹, Z. W. Fitch¹, M. Manook¹, J. Yoon¹, A. B. Farris², J. Kwun¹, S. J. Knechtle¹
¹Department of Surgery, Duke University Medical Center, Durham, NC, ²Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA
*Purpose: Desensitization with costimulation blockade and proteasome inhibition prior to kidney transplantation prevents early antibody-mediated rejection (AMR) and prolongs graft survival in highly sensitized nonhuman…