2013 American Transplant Congress
Interactions of B and T Regulatory Cells in Normal Volunteers and in Tolerant HLA-Identical Kidney Transplant Recipients
Surgery; Comprehensive Transplant Center, Northwestern University, Chicago, IL
Purpose: In an HLA Identical (id) renal transplant (RT) tolerance trial using donor hematopoietic stem cells, alemtuzumab induction, and temporary maintenance immunosuppression (IS), primarily with…2013 American Transplant Congress
Ileal FGF15/19 to Hepatocyte FGFR4 Axis Is a Novel Positive Regulator of Liver Regeneration after Partial Hepatectomy in Mice
Organ Transplant Center, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
Liver regeneration after partial hepatectomy (PH) or living donor liver transplantation (LDLT) is a complicated biological process, which is not only regulated by liver itself…2013 American Transplant Congress
Predictors of Post-Transplant Cardiac Dysfunction in Liver Transplant Recipients
Gastroenterology and Hepatology, Henry Ford Medical Center, Detroit, MI
BackgroundHeart failure (HF) after liver transplantation (LT) is poorly understood. Small, retrospective studies have analyzed new onset systolic HF after LT, but rates are variable…2013 American Transplant Congress
Genetic and Pharmacologic Evidence for the Essential Role of the Deubiquitinase, USP7, in Maintaining Foxp3 Expression and Promoting Treg Function
UPenn/CHOP, Philadelphia, PA; Columbia University, New York, NY; Progenra, Malvern, PA
Foxp3 is subjected to multiple post-translational modifications that govern Treg function. E.g. The histone acetyltransferases, p300 and CBP, acetylate Foxp3, increasing its stability and promoting…2013 American Transplant Congress
Subnormothermic Ex Vivo Liver Perfusion (SNEVLP) Reduces Ischemia/Reperfusion Injury in Livers Retrieved after Cardiac Death
We compared the impact of cold static liver preservation vs subnormothermic ex vivo liver perfusion (SNEVLP) on outcome of DCD pig liver transplantation (LT). Methods:…2013 American Transplant Congress
Tolerance Requires Unique Remodeling of Lymph Node Structure and Stromal Fibers
University of Maryland, Baltimore
Background: Immunity and tolerance are regulated by changes in secondary lymphoid organ (SLO) structure and function. SLO structural elements include the fibers ER-TR7, desmin, and…2013 American Transplant Congress
Essential Role of CBP in Maintaining Foxp3 Stability during Inflammatory Events
CD4+ T-regulatory (Treg) cells maintain self-tolerance and control immune responses to nonself-antigens, and thereby limit excessive inflammation. High level and stable expression of Foxp3 transcription…2013 American Transplant Congress
Trends in Usage and Outcomes for Expanded Criteria Donor Kidney Transplantation
Duke University Medical Center, Durham, NC; Clinical Trials and Consulting Services, Cincinnati, OH
Expanded criteria donor (ECD) kidneys have been incorporated into the donor pool over the past decade to combat organ shortages. We sought to analyze the…2013 American Transplant Congress
Shared Decision Making in Organ Transplantation
Background: Shared Decision Making (SDM) is a model of patient-provider communication stressing communication and joint participation in healthcare decisions to provide mutually agreed upon treatment.…2013 American Transplant Congress
Internet Use among Kidney Transplant Candidates
Northwestern University Feinberg School of Medicine, Chicago
Background: The Internet is a convenient, immediate, cost-effective, and private way to deliver healthcare information necessary for making informed treatment decisions. Little is known about…
American Transplant Congress abstracts