2013 American Transplant Congress
Overcoming Hyperacute Rejection of Monkey ABO-Incompatible Renal Transplantation Using a Complement Inhibition-Based Strategy
Background: It has been demonstrated that complement inhibition-based strategy enables renal allograft accommodation and long-term engraftment in donor skin-presensitized monkeys. The effect of the same…2013 American Transplant Congress
Differential Regulation of Regulatory T Cells and Th17 Cells by mTOR Inhibitor in Kidney Transplant Recipients
Background : Accumulating evidence suggests that Treg/Th17 axis have important role in long term allograft survival in kidney transplantation. The aim of this study is…2013 American Transplant Congress
Microcirculation Inflammation Is Superior to Peritubular Capillary Basement Membrane Multilayering for Outcome Prediction in Renal Transplant Patients with De Novo Donor-Specific Antibodies
Imperial College NHS Trust, London, United Kingdom; , United Kingdom
In renal transplant patients with de novo donor-specific antibodies (DSA) we compared peritubular capillary basement membrane multilayering (PTCBML) counts with microcirculation inflammation (MI) score to…2013 American Transplant Congress
Anti-ER-TR7 mAb Prevents Tolerogenic Lymph Node Morphogenesis and Overrides Transplant Tolerance
University of Maryland, Baltimore
Background: Transplant tolerance is exquisitely sensitive to changes in secondary lymphoid organ structure and function. Costimulatory blockade plus donor-specific splenocyte transfusion (DST) induces long-term graft…2013 American Transplant Congress
Treatment of Chronic Antibody-Mediated Rejection after Kidney Transplantation: Does Rituximab and Intravenous Globulins Improve Graft Survival?
Background . Chronic antibody-mediated rejection (CAMR) is a major cause of renal graft loss and there is no evidence-based treatment. Patients and methods . All…2013 American Transplant Congress
Lack of Association between Infection and Increased Sensitization in Kidney Transplant Recipients
Montefiore-Einstein Transplant Center, Bronx, NY
Background: We investigated the association between bacterial/fungal infection and increased sensitization in post-transplant kidney transplant recipients due to interaction between innate and adaptive immunity and/or…2013 American Transplant Congress
U.S. Experience in ABO Incompatible Pediatric Heart Transplantation, The
Background. On 11/22/10, an ABO-incompatible (ABO-i) pediatric (ped) heart (HR) policy was implemented. This policy allows Status 1A/1B ped candidates <2 yrs at listing who…2013 American Transplant Congress
Microcirculation Injury Associates with Donor-Specific Anti-HLA Antibodies in ABO Incompatible Renal Transplant Patients
Imperial College NHS Trust, London, United Kingdom; Royal Infirmary, Manchester, United Kingdom
Detecting antibody-mediated damage in ABO incompatible (ABOi) renal transplants has been hampered by the lack of usefulness of C4d staining. We assessed the relevance of…2013 American Transplant Congress
Donor Specific Antibody (DSA) Does Not Predict Inflammation, Fibrosis, or C4d Score in 12 Tolerant Pediatric Liver Transplant (LT) Recipients: 5+Year Longitudinal Follow-Up
BACKGROUND ITN029, a multicenter pilot trial (n=20) of immunosuppression withdrawal (ISW) in pediatric recipients of parental living donor LTs, identified 12 tolerant participants (pts). The…2013 American Transplant Congress
Long-Term Assessment of Function in Patients Completing the Spare-the-Nephron Study with a Functioning Graft
Div of Nephrology, Dept of Medicine, Univ of Maryland School of Medicine, Baltimore, MD
In the Spare-the-Nephron (STN) study (Weir MR et al. Kidney Int 2011;79:897-907) kidney transplant recipients randomized about 115 days post-transplant to convert from CNI (calcineurin…
American Transplant Congress abstracts