ATC Abstracts

American Transplant Congress abstracts

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  • 2013 American Transplant Congress

    Cytomegalovirus and Post-Transplant Cancer: Protection, Predisposition or No Effect?

    R. Desai, D. Collett, J. Neuberger

    NHS Blood and Transplant, Bristol, United Kingdom

    The role of Cytomegalovirus (CMV) in development of post-transplant de novo cancer is not established. Previous studies have suggested that CMV exposure is associated with…
  • 2013 American Transplant Congress

    Urinary Transcript Expression Profile in Kidney Transplant Recipients Is Predictive for Post-Transplant Graft Function

    M. Gasser, I. Tsaur, K. Lopau, C. Germer, A. Chandraker, A. Waaga-Gasser

    Department of Surgery I, University of Wuerzburg, Wuerzburg, Germany; Department of Urology, University of Frankfurt, Frankfurt, Germany; Department of Nephrology, University of Wuerzburg, Wuerzburg, Germany; Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

    There is evidence that non-invasive immunological monitoring may be useful in the early period after renal transplantion, particularly with regard to predicting acute rejection. It…
  • 2013 American Transplant Congress

    Invasive Fungal Infection in Liver Transplant Recipients – Focus on Underestimated Risk Factors Associated with In-Hospital Mortality

    I. Göcze, A. Pross, F. Zeman, S. Farkas, M. Scherer, S. Lang, M. Loss, B. Graf, T. Bein, H. Schlitt

    Departments of Surgery and Anaestesiology, University Hospital, Regensburg, Germany

    Background: Invasive fungal infections (IFIs) in liver transplant recipients are associated with increased mortality. Although the risk factors for developing IFIs have been extensively investigated,…
  • 2013 American Transplant Congress

    Factors Affecting the Humoral Response to HLA Antigens

    D. Lucas, M. Leffell, A. Zachary

    Medicine, Johns Hopkins University School of Medicine, Baltimore, MD

    Post-transplant antibody (Ab) to donor HLA is associated with reduced graft survival, but it is unknown if some HLA antigens are more likely to induce…
  • 2013 American Transplant Congress

    Novel Candidate Markers Characterizing Cellular Senescence in Aged Zero Hour Kidney Biopsies Predict Post Transplant Outcome

    K. Kotsch, J. Guenther, P. Hutter, H. Schwelberger, M. Biebl, S. Schneeberger, R. Öllinger, A. Weissenbacher, H. Neuwirt, G. Mayer, D. Stauch, A. Pascher, P. Neuhaus, J. Pratschke

    Department for Surgery, Medical University Innsbruck, Innsbruck, Austria; Division of Nephrology, Medical University Innsbruck, Innsbruck, Austria; Department for Surgery, Charité-Universitätsmedizin Berlin, Berlin, Germany

    Advanced donor age adversely affects allograft outcome following renal transplantation. Candidate genes involved in cell-cycle regulation and telomere shortening have been already described as markers…
  • 2013 American Transplant Congress

    Toll Like Receptor Signaling Pathway Activated and Inflammation Amplified in Naked Caspase-3 siRNA Preserved Auto-Transplant Porcine Kidneys

    C. Yang, L. Li, Y. Xue, Z. Zhao, T. Zhao, Y. Jia, R. Rong, M. Xu, M. Nicholson, T. Zhu, B. Yang

    Zhongshan Hospital, Fudan University, Shanghai, Christmas Island; Shanghai Key Laboratory of Organ Transplantation, Shanghai, China; University of Leicester, Leicester General Hospital, Leicester, United Kingdom; Affiliated Hospital of Nantong University, Nantong, China

    Background. In our previous study, naked caspase-3 siRNA infused into the renal artery during cold preservation was effective, but did not protect the auto-transplant kidneys…
  • 2013 American Transplant Congress

    Population Pharmacokinetics of Tofacitinib in De Novo Kidney Transplant Patients

    M. Tortorici, M. Lamba, G. Chan, S. Krishnaswami

    Pfizer Inc, Groton, CT

    Introduction: Tofacitinib is a novel, oral Janus kinase inhibitor being investigated as a targeted immunomodulator. Tofacitinib achieved comparable rate of biopsy-proven acute rejection and improved…
  • 2013 American Transplant Congress

    Donor Derived Transmission Events in 2012: A Report of the OPTN Ad Hoc Disease Transmission Advisory Committee (DTAC)

    M. Green, S. Covington, S. Taranto, W. Bell, S. Biggins, E. Blumberg, G. DeStafano, E. Dominguez, D. Ennis, T. Gross, M. Klassen-Fischer, C. Kotton, S. Kusne, Y. Law, M. Menegus, R. Miller, M. Pavlakas, T. Pruett, D. LaPointe-Rudow, P. Ruiz, N. Siparsky, M. Souter, L. Weiss, C. Wolfe, D. Kaul

    1OPTN Ad Hoc Disease Transmission Advisory Committee, Richmond, VA; United Network for Organ Sharing, Richmond, VA

    The OPTN DTAC, a multidisciplinary committee, evaluates potential donor derived transmission events (PDDTE), including infections (I) & malignancies (M), to assess for donor transmitted events.Methods:…
  • 2013 American Transplant Congress

    Lung Recipients with Post-Transplant Lung Cancer and Comparison with Other Organ Recipients

    R. Desai, D. Collett, T. Evans, J. Neuberger

    Organ Donation and Transplantation, NHS Blood and Transplant, Bristol, United Kingdom; West Midlands Cancer Intelligence Unit, University of Birmingham, Birmingham, United Kingdom

    The burden and impact of lung cancer among transplant recipients and a comparison between recipients of lung and other organs has been studied in small…
  • 2013 American Transplant Congress

    Sepsis after Renal Transplantation: Clinical, Microbiological, and Immunological Characteristics

    T. Schachtner, P. Reinke

    Nephrology and Internal Intensive Care, Charité Campus Virchow Clinic, Berlin, Germany; Berlin-Brandenburg Center for Regenerative Therapies, Berlin, Germany

    As immunosuppressive drugs and allograft survival have improved over the last decades, infection has become the main hurdle of patient survival and long-term allograft function…
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