The OPTN DTAC, a multidisciplinary committee, evaluates potential donor derived transmission events (PDDTE), including infections (I) & malignancies (M), to assess for donor transmitted events.
Methods: Reports of unexpected PDDTE to OPTN from 1/1/12-10/31/12 were reviewed by DTAC. Reviews of reports submitted by 9/5/12 are complete; the remainder are still being evaluated. We utilized a new standardized algorithm for classification for each donor (D) & for the first time classified each individual recipient (R) for reported donors.
Results: Evaluations of 135/166 reported PDDTE are complete. 22/132 reported D had proven/probable (P/P) transmission of I or M to 31/370 total R. Six reports involved live donors (1 I, 5 M); 1 resulted in transmitted disease. 17/89 potential infection events were classified as P/P affecting 25 R, resulting in 3 deaths. Bacteria were most frequently reported (31) but only 4 R from 4 D experienced P/P transmission. HBV & HCV accounted for 19 reports; 6 R had P/P transmissions from 3 D. Parasites/amoeba accounted for 9 reports resulting in 10 P/P infected R from 5 D. 5/43 D reported with potential malignancy events were classified as P/P, with 5 affected R and 1 death. Three additional non-I, non-M PDDTE were also reported; 1 resulting in probable transmission. Overall, the 23 PDDTE P/P donor events resulted in P/P transmission to 12 kidney, 9 liver, 4 heart & 6 lung R.
Conclusions: There were increased PDDTE reported in 2012; the percent with P/P transmissions remains low (17% of reported cases), especially when compared with total number of annual transplants. Parasites/amoeba accounted for the largest number of documented transmission events affecting 2 R per infected D. Attention to outcome of all R should enhance our ability to develop strategies to reduce adverse events related to PDDTE.
To cite this abstract in AMA style:Green M, Covington S, Taranto S, Bell W, Biggins S, Blumberg E, DeStafano G, Dominguez E, Ennis D, Gross T, Klassen-Fischer M, Kotton C, Kusne S, Law Y, Menegus M, Miller R, Pavlakas M, Pruett T, LaPointe-Rudow D, Ruiz P, Siparsky N, Souter M, Weiss L, Wolfe C, Kaul D. Donor Derived Transmission Events in 2012: A Report of the OPTN Ad Hoc Disease Transmission Advisory Committee (DTAC) [abstract]. Am J Transplant. 2013; 13 (suppl 5). https://atcmeetingabstracts.com/abstract/donor-derived-transmission-events-in-2012-a-report-of-the-optn-ad-hoc-disease-transmission-advisory-committee-dtac/. Accessed April 4, 2020.
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