2013 American Transplant Congress
Olmesartan, Angiotensin II Type 1 Receptor Blocker, Induced Prolonged Survival of Murine Cardiac Allografts and Generated Regulatory Cells
Surgery, Teikyo University, Tokyo, Japan; Surgery, Aisei Hospital, Tokyo, Japan
Background: Several studies have shown that angiotensin II type 1 receptor (AT1 receptor) blockade reduced graft arteriosclerosis and immune-mediated graft damages. Here, we investigated the…2013 American Transplant Congress
Evidence That Anti-Interleukin-6 Receptor Treatment Modulates Splenic T-Cell Subsets during Development of Allosensitization
Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA
Introduction: We previously reported that inhibition of IL-6/IL-6R interactions by an anti-IL6R monoclonal (mMR16-1) attenuates anti-HLA-A2 responses in a mouse model of sensitization. The current…2013 American Transplant Congress
Baicalin Mediates Renal IRI Protection through Inhibition of NF-κB Pathway and Mitochondria Mediated Apoptosis
Background: Renal ischemia reperfusion injury (IRI) would highly increase the risk of delayed graft function (DGF) and rejection, and subsequently decrease the long-term graft survival…2013 American Transplant Congress
Gender Difference in Renal Ischemia Tolerance Is Extrinsic to the Kidney
Background: Gender has been shown to have some impact on tolerance of ischemia-reperfusion injury (IRI) in animal models, with female mice having greater IRI tolerance.…2013 American Transplant Congress
Pharmacokinetics of Voclosporin (VCS) in Renal Impairment, The
Isotechnika Pharma Inc, Edmonton, Canada
Objective:To determine the pharmacokinetic profile of VCS in subjects with renal impairment.Methods:VCS 0.4 mg/kg was administered to subjects with Normal, Mild, Moderate, or Severe renal…2013 American Transplant Congress
Flow Is Critical for Maintaining a Protective Phenotype in Renal Proximal Tubular Cells
Background. The impact of flow cessation on proximal tubular cell homeostasis and glomerulotubular balance is of clinical significance during renal ischemia and organ preservation. Consequences…2013 American Transplant Congress
Hypothermic Machine Perfusion To Optimise the Timing of Renal Transplantation
BackgroundConflict has always existed between Cold Ischaemic Time (CIT) and safe, timely transplantation. Keeping CIT short may entail operating on complex patients with considerable co-morbidity…2013 American Transplant Congress
Effects of Hepatic Impairment on Single and Multiple Oral Dose Pharmacokinetics of Voclosporin (VCS)
Isotechnika Pharma Inc, Edmonton, AB, Canada
Objective:To determine the pharmacokinetic profile of VCS in subjects with hepatic impairment after single or multiple doses.Methods:VCS 0.4 mg/kg was administered to subjects with hepatic…2013 American Transplant Congress
Simple Cardiovascular Risk Score Predicts Mortality in Kidney Transplant Candidates, A
Renal Unit, Lister Hospital, Stevenage, United Kingdom
For patients with renal failure kidney transplantation (KTx) confers improved quality and length of life. The survival benefit from KTx is limited by death from…2013 American Transplant Congress
Dual Kidney Transplants from Marginal Donors: Double or Nothing
Surgery, Wake Forest School of Medicine, Winston Salem, NC
The purpose of this study was to review retrospectively our single center experience with adult dual kidney transplants (DKT) from marginal donors with limited nephron…
American Transplant Congress abstracts