Abstracts Archive - Page 1487 of 1683 - ATC Abstracts

2015 American Transplant Congress
CHBP in Preservation Solution and Autologous Blood Perfusate Ameliorates Ischemia Reperfusion Injury in Isolated Porcine Kidneys
C. Yang,¹ S. Hosgood,² H. Carly,² P. Meeta,² Y. Long,³ T. Zhu,¹ M. Nicholson,² B. Yang.²
¹Urology, Zhongshan Hospital, Fudan University, Shanghai, China; ²Transplant Group, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester General Hospital, Leicester, China; ³Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Background. There is an imperative need to better preserve isolated organs before transplantation. A non-erythropoiesis cyclic helix B peptide (CHBP) derived from erythropoietin was newly…
2015 American Transplant Congress
The Influence of Immunosuppressive Drugs On the Epithelial Microenvironment in Solid Organ Transplantation – Identification of Biomarker Candidates for Rejection Vs. Tolerance
A. Akhdar,¹ B. Mueller,² C. Neudoerfl,¹ F. Lehner,³ M. Stevanovic-Meyer,¹ K. Daemen,¹ J. Keil,¹ H. Haller,⁴ C. Blume,^4,5 C. Falk.^1,6
¹Institute of Transplant Immunology, IFB-Tx, Hanover Medical School, Hanover, Germany; ²MorphoSys, Munich, Germany; ³Department of General, Visceral and Transplantation Surgery, Hanover Medical School, Hanover, Germany; ⁴Department of Nephrology and Hypertension, Hanover Medical School, Hanover, Germany; ⁵Institute of Technical Chemistry, Leibniz University Hanover, Hanover, Germany; ⁶German Center for Infection Research, Braunschweig, Germany.
In the context of kidney transplantation, NK cells may play an important role by targeting the allogeneic organ due to "missing-self recognition", which leads to…
2015 American Transplant Congress
Low Molecular Weight Hyaluronan Increases MIG and MCP-1 Production in Cardiac Allografts
S. Goparaju,¹ A. Kaul,¹ N. Dvorina,¹ S. Iida,¹ K. Keslar,¹ R. Fan,¹ C. de la Motte,² A. Valujskikh,¹ R. Fairchild,¹ W. Baldwin III.¹
¹Immunology, Cleveland Clinic, Cleveland, OH; ²Pathobiology, Cleveland Clinic, Cleveland, OH.
Macrophages engage in extracellular matrix remodeling both degrading and synthesizing hyaluronan. Hyaluronan is a high molecular weight ( > 1000 kDa) extracellular matrix component that…
2015 American Transplant Congress
The Impact of Cytokine Release Caused By Induction Immunosupression On Nitric Oxide in Renal transplantation
R. Johns,^1,2 M. Laftsidis,² E. Burrows,² F. Edwards,² E. Ablorsu,² P. James,¹ A. Phillips,^1,2 A. Asderakis.²
¹University of Cardiff, Cardiff, United Kingdom; ²University Hospital of Wales, Cardiff, United Kingdom.
IntroductionVarying induction immunosuppression regimens have a differential impact on the pattern of cytokine release. Pro-inflammatory cytokines stimulate endothelial cells causing secretion of NO. Serum nitrite…
2015 American Transplant Congress
Type III Phosphodiesterase (PDE3) Inhibitor Improves Survival Rate After Ischemia Reperfusion Injury of the Liver in Rats
T. Fujii,¹ H. Obara,² N. Fujimura,² K. Matsubara,² Y. Kitagawa.²
¹Surgery, Inagi Municipal Hospital, Tokyo, Japan; ²Surgery, Keio University School of Medicine, Tokyo, Japan.
BackgroundPDE3 inhibitor (Cilostazol) has long been used as a potent inhibitor of platelet aggregation and thrombosis. Recently, there have been a report on the protective…
2015 American Transplant Congress
Chemokine Receptor 5 Blockade Modulates Inflammation and Immunity in Renal Ischemic Reperfusion Injury
K. Yoo,¹ S. Han,¹ J. Park,¹ E. Bae,¹ J. Park,¹ J. An,¹ J. Lee,¹ D. Kim,¹ Y. Kim,^1,2 S. Yang.²
¹Internal Medicine, Seoul National University Hospital, Seoul, Korea; ²Kidney Research Institute, Seoul National University, Seoul, Korea.
Macrophages, which exhibit great pliability, are important components of renal ischemic reperfusion injury (IRI) and are closely correlated with loss of renal function. Chemokine Receptor…
2015 American Transplant Congress
NK Cells of Kidney Transplant Recipients Show a Reduced Capacity to Produce Cytokines But Retain Their Cytotoxic Capacity
U. Hoffmann,¹ C. Neudoerfl,¹ K. Daemen,¹ J. Keil,¹ C. Blume,^2,3 F. Lehner,⁴ H. Haller,² C. Falk.^1,5
¹Inst. of Transplant Immunology, IFB-Tx, Hanover Medical School, Hanover, Germany; ²Dept. of Nephrology and Hypertension, Hanover Medical School, Hanover, Germany; ³Inst. of Technical Chemistry, Leibniz University Hanover, Hanover, Germany; ⁴Dept. of General, Visceral, and Transplantation Surgery, Hanover Medical School, Hanover, Germany; ⁵German Center for Infection Research, Braunschweig, Germany.
The role of NK cells in either graft rejection or tolerance induction is still discussed controversially. In order to clarify the effect of long-term immunosuppression…
2015 American Transplant Congress
A Mouse Model of Pneumonitis Induced by Candida Albicans Infection After Allogeneic Skin Transplantation
A. Yang, Z. Guo, W. Ju, Y. Ma, A. Hu, Y. Chen, M. Chen, C. Wu, X. He.
Organ Transplantation Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
Aims:Our study was to build up a mouse model of pneumonitis induced by candida albicans infection after allogeneic skin transplantation.Methods:We used 10 male C57BL/6J mice…
2015 American Transplant Congress
A Novel Signaling Approach for the Prevention of Ischemia/Reperfusion Injury (IRI)
S. Khalid,¹ M. Haller,¹ K. Koziel,¹ M. Enthammer,¹ M. Hermann,² M. Thurner,¹ L. Kremser,³ H. Lindner,³ J. Troppmair.¹
¹VTT, DSL, Innsbruck Medical University, Innsbruck, Austria; ²Anestesiology and Critical Care Medicine, Innsbruck Medical Unversity, Innsbruck, Austria; ³Division of Clinical Biochemistry, Innsbruck Medical University, Innsbruck, Austria.
Mitochondrial reactive oxygen species (ROS) produced during early reperfusion are important triggers for the development of ischemia/reperfusion injury (IRI). However, antioxidants yielded little clinical benefit…
2015 American Transplant Congress
Activated Protein C Treatment Protects Steatotic and Non-Steatotic Livers Under Ischemia–Reperfusion Injury in Different Manner
A. Matsuda, N. Kuriyama, H. Kato, Y. Azumi, M. Kishiwada, S. Mizuno, M. Usui, S. Isaji.
Hepatobiliary Pancreatic and Transplant Surgery, Mie University Graduate School of Medicine, Tsu, Mie, Japan.
Activated protein C (APC) is known to have the cytoprotective effect on liver ischemia–reperfusion injury (IRI) in rat models. However, it is unclear that whether…