2015 American Transplant Congress
Macrophage Specific β-Catenin Controls ROCK/PTEN Function and Regulates Innate Immunity in Liver Inflammation
Background: It has been shown that β-catenin is an important regulator of cell development, regeneration, and carcinogenesis. Our previous studies demonstrated the key role of…2015 American Transplant Congress
Hepatic Stellate Cells Inhibit T Cells Through Active TGFβ1 from a Cell-Surface-Bound Latent TGFβ1/GARP Complex
Nonparenchymal cells appear to be critical to maintain the immunoprivileged status of liver as whole liver allografts are well-tolerated in mice, but allo-hepatocytes are rapidly…2015 American Transplant Congress
An Orchestrated Sequence of Innate and Adaptive Immune Responses Is Associated With Rejection After Pediatric Liver Transplantation
The concept of a coordinated immune response initiated by innate and sustained by adaptive immune cells and their soluble mediators is well established for infection…2015 American Transplant Congress
The Impact of FcγRIIA, FcγRIIIA and C1QA Genes Polymorphism On Infectious Complications Following Renal Transplantation
Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan.
AIM- Infectious complication is the leading cause of graft and patient loss after renal transplantation (RT). Under immunosuppressive condition when acquired immunity is suppressed, components…2015 American Transplant Congress
Cellular Mechanism of Enhanced Alloimmunity by Ischemia Reperfusion Injury
Transplant Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Ischemia reperfusion injury of transplanted organs represents a key pathogenic inflammatory process, which increases their allogenicity; subsequently augmenting the rate of acute and chronic rejection.…2015 American Transplant Congress
Oxidative Stress During Organ Recovery Influences Transplant Vasculopathy Development
Transplant vasculopathy is still a major obstacle to long-term graft survival. Pharmacological strategies aiming at preventing it are still lacking. Herein we show that the…2015 American Transplant Congress
Non-Invasive Immune Monitoring Assay in Transplant Recipients
A reliable non-invasive assay of immune responsiveness would help to predict the development of chronic rejection, stable function or tolerance in transplant recipients. Our aim…2015 American Transplant Congress
Recipient Myelomonocytic Cells With Activated Hypoxia-Inducible Factor Alleviate Ischemia-Reperfusion Injury in Mouse Heart Allografts
Aim: To investigate the effect of HIF-1α and -2α activation in myelomonocytic cells during the early phase after ischemia-reperfusion (IRI) injury of mouse allogenic heart…2015 American Transplant Congress
The Effects of Periostin on Renal Fibrosis After Ischemia-Reperfusion Injury Via p38 MAPK Pathway
Ischemia-reperfusion injury during the transplantation procedure is associated with poor long-term allograft outcomes, such as rejection and fibrosis. Periostin, a matricellular protein, has been reported…2015 American Transplant Congress
Significant Reduction in TRAIL-Expressing NK Cells in Remnant Liver After Partial Hepatectomy Is Strongly Associated With the Impaired Intrahepatic CXCL9–CXCR3 Pathway
Antitumor activity of liver natural killer (NK) cells decreases after partial hepatectomy or liver transplantation (LT), suggesting the susceptibility of patients with depressed immune status…
American Transplant Congress abstracts