Abstracts Archive - Page 1473 of 1683 - ATC Abstracts

2015 American Transplant Congress
Combination of Clinical and Genetic Factors for Delayed Kidney Graft Function Prediction
A. Goncalves-Primo,^1,2 E. Campos,^1,2 J. Medina-Pestana,^2,3 H. Tedesco-Silva,³ M. Gerbase-DeLima.^1,2
¹Immunogenetics Institute, AFIP, São Paulo, SP, Brazil; ²Universidade Federal de São Paulo, São Paulo, SP, Brazil; ³Hospital do Rim e Hipertensão- FOR, São Paulo, SP, Brazil.
In this study we sought to determine the risk for delayed graft function (DGF) in kidney transplants (Tx) with deceased donors (DD) through the analysis…
2015 American Transplant Congress
MicroRNA-21 (miR-21) Expression in Hypothermic Machine Perfusate May Predict Early Outcomes in Kidney Transplantation
U. Khalid,^1,2 E. Ablorsu,² L. Szabo,² R. Jenkins,¹ T. Bowen,¹ D. Fraser,¹ R. Chavez.^1,2
¹Institute of Nephrology, Cardiff University, Cardiff, United Kingdom; ²Cardiff Transplant Unit, University Hospital of Wales, Cardiff, United Kingdom.
Introduction: Hypothermic machine perfusion is effective in improving outcomes from kidney transplantation and molecular analyses of hypothermic machine perfusate (HMP) have the potential to identify…
2015 American Transplant Congress
Elderly ESRD Patients Have a Significantly Narrowed T-Cell Receptor Repertoire Diversity
L. Huang,¹ A. Langerak,² I. Wolvers - Tettero,² R. Meijers,¹ C. Baan,¹ N. Litjens,¹ M. Betjes.¹
¹Internal Medicine, Erasmus Medical Center, Rotterdam, Netherlands; ²Immunology, Erasmus Medical Center, Rotterdam, Netherlands.
IntroductionA diverse T-cell receptor (TCR) repertoire is central to effective T-cell mediated immune responses to foreign antigens. Patients suffering from end stage renal disease (ESRD)…
2015 American Transplant Congress
Differentially Expressed IL-6Rα and GP130 Genes in Kidney Biopsies (Bxs) Suggests Different Roles of IL-6 Signaling in Antibody (ABMR)- and Cell (CMR)-Mediated Rejection
H. Zhang,¹ D. Thomas,¹ J. Kowalewska,² E. Suviolahti,¹ H. Shafi,² C. Nast,² A. Gertych,² A. Vo,¹ M. Haas,² S. Jordan,¹ M. Toyoda.¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA; ²Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.
Background: IL-6 exerts immunoregulatory properties through IL-6 receptors, IL-6Rα and gp130. Our previous studies suggested the involvement of antibody-dependent cellular cytotoxicity (ADCC) and its related…
2015 American Transplant Congress
Frequencies of CD4⁺25^hiFoxp3⁺T Cells in Long-Term Follow-Up of Sirolimus-Converted Kidney Transplant Recipients
O. Traitanon,^1,2 A. Alvarado,¹ E. Tantisattamo,^1,2 A. Shetty,^1,2 M. Ansari,^1,2 J. Mathew,¹ J. Leventhal,¹ V. Mas,³ L. Gallon.^1,2
¹Comprehensive Transplant Center, Northwestern University, Chicago, IL; ²Medicine-Nephrology, Northwestern University, Chicago, IL; ³Surgery, University of Virginia, Charlottesville, VA.
Background: Tacrolimus(TAC) and Sirolimus(SRL) are commonly used immunosuppressive drugs in kidney transplantation. SRL has been shown to induce the expansion of regulatory T cells in…
2015 American Transplant Congress
Donor Serum and Urine Proteomic Signatures Differentiate Between Immediate and Delayed Graft Function in Kidney Transplantation
M. Kaisar,^1,2 H. Huang,^1,2 Z. Akhtar,¹ H. Leuvenink,³ B. Kessler,² R. Ploeg.¹
¹Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom; ²Target Discovery Institute, University of Oxford, Oxford, United Kingdom; ³Surgical Research Laboratory, UMC, Groningen, Netherlands.
IntroductionDespite the persistent shortage of donor organs, paradoxically, many organs obtained from older higher risk donors are deemed unsuitable for transplantation and discarded. The ability…
2015 American Transplant Congress
Detection of Donor-Specific Anti-HLA Antibodies Is Associated With Changes in the Peripheral Distribution of NK Cell Subsets in Kidney Allograft Recipients
M. Crespo,¹ D. Redondo,¹ J. Yelamos,² A. Muntasell,² M. Pérez-Sáez,¹ M. Lopez-Montañes,³ C. Garcia,⁴ A. Torío,⁵ J. Hernandez,⁴ M. Mir,¹ M. Lopez-Botet,³ J. Pascual.¹
¹Nephrology, Hospital del Mar, Barcelona, Spain; ²Servicio de Inmunología, Institut Mar d'Investigacions Mediques, Barcelona, Spain; ³Grup de Investigacio en Immunologia, Universitat Pompeu Fabra, Barcelona, Spain; ⁴Laboratori de Referencia de Catalunya, Barcelona, Spain; ⁵Immunology Unit, Hospital de Alicante, Alicante, Spain.
Background: Microvascular damage has become the real protagonist involved in antibody-mediated rejection and NK-cell antibody-dependent cell mediated cytotoxicity (ADCC) has been proposed as a contributing…
2015 American Transplant Congress
The Association of Systemic Indoleamine 2,3 Dioxygenase (IDO) Activity Simultaneous With Chronic Rejection On Allograft Kidney Biopsy
V. Dharnidharka, L. Hesemann, J. Mitsios, H. O'Gorman, M. Gunasekaran, D. Dietzen, T. Mohanakumar.
Washington University School of Medicine, St Louis.
Introduction: Previous studies from our group have shown that activity of the biomarker enzyme IDO elevates prior to acute rejection in kidney transplant recipients, as…
2015 American Transplant Congress
Phenotypic Personalized Medicine: Mechanism-Independent Convergence Into Target Serum Tacrolimus Levels for Optimized Liver Transplant Immunosuppression
A. Zarrinpar,¹ A. Silva,² D.-K. Lee,³ N. Datta,¹ C.-M. Ho,² D. Ho.³
¹Surgery-Division of Liver and Pancreas Transplantation, UCLA, Los Angeles, CA; ²Mechanical Engineering, UCLA, Los Angeles, CA; ³Bioengineering, and Oral Biology and Medicine, UCLA, Los Angeles, CA.
PURPOSE:Immunosuppressive drugs such as tacrolimus have narrow therapeutic ranges and their dosing variability necessitates intensive drug monitoring. This study aimed to use Feedback System Control…
2015 American Transplant Congress
Implication of Intragraft γδ T Cell Profiles in Operational Tolerance After Clinical Transplantation of Highly Immunogenic Intestine -Difference from Immunoprivileged Liver
Y. Li,¹ X. Zhao,¹ H. Ohe,² H. Nafady-Hego,³ A. Bishop,⁴ J. Pirenne,⁵ T. Koshiba.⁶
¹Kyoto University, Kyoto, Japan; ²Matsue Red Cross Hospital, Matsue, Japan; ³Assiut Universty, Assiut, Egypt; ⁴University of Sydney, Sydney, Australia; ⁵University of Leuven, Leuven, Belgium; ⁶Fukushima Medical University, Fukushima, Japan.
(Background) T-cell receptor (TCR) Vδ2 γ δ T cells (Vδ 2 cells) participate in host defense, whereas Vδ 1 γ δ T cells (Vδ 1…